Lung Cancer

Oliver, Armando L.

doi:10.1016/j.suc.2021.12.001

Cited by 131 publications

(56 citation statements)

References 25 publications

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“…Recent studies suggest that intestinal flora have immune functions in addition to its barrier role in the gastrointestinal tract, and that dysbiosis of the intestinal flora is associated with inflammatory and malignant diseases of the gastrointestinal system. In recent years, it has been shown that imbalance or dysregulation of the gut microbiota is associated with development of various tumors [ 5 – 7 ]. There is a close relationship between the theory of "the lung and large intestine are external and internal" and the concept of the “lung-gut axis” in clinical medicine.…”

Section: Introductionmentioning

confidence: 99%

Association of lung-intestinal microecology and lung cancer therapy

et al. 2023

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In recent years, the incidence of lung cancer is increasing. Lung cancer has become one of the most malignant tumors with the highest incidence in the world, which seriously affects people’s health. The most important cause of death of lung cancer is metastasis. Therefore, it is crucial to understand the mechanism of lung cancer progression and metastasis. This review article discusses the physiological functions, pathological states and disorders of the lung and intestine based on the concepts of traditional Chinese medicine (TCM), and analyzes the etiology and mechanisms of lung cancer formation from the perspective of TCM. From the theory of “the exterior and interior of the lung and gastrointestinal tract”, the theory of “the lung-intestinal axis” and the progression and metastasis of lung cancer, we proposed e “lung-gut co-treatment” therapy for lung cancer. This study provides ideas for studying the mechanism of lung cancer and the comprehensive alternative treatment for lung cancer patients.

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Section: Introductionmentioning

confidence: 99%

Association of lung-intestinal microecology and lung cancer therapy

et al. 2023

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“…Lung cancer is one of the most common malignancies ( 1 ). For more than a decade, lung cancer has remained the leading cause of cancer death worldwide ( 1 ).…”

Section: Introductionmentioning

confidence: 99%

“…Lung cancer is one of the most common malignancies ( 1 ). For more than a decade, lung cancer has remained the leading cause of cancer death worldwide ( 1 ). Lung cancer is divided into small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC), of which NSCLC accounts for about 85–90% and mainly includes lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

HnRNPAB is an independent prognostic factor in non‑small cell lung cancer and is involved in cell proliferation and metastasis

et al. 2023

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Heterogeneous nuclear ribonucleoprotein A/B (hnRNPAB) is an RNA binding protein that is closely associated with the biological function and metabolism of RNA, which is involved in the malignant transformation of various tumor cells. However, the role and mechanisms of hnRNPAB in non-small cell lung cancer (NSCLC) are still unclear. In the present study, the expression levels of hnRNPAB in NSCLC and normal tissues were analyzed using the human protein atlas database and UALCAN database. The clinical significance of hnRNPAB was assayed using the data of NSCLC cases from The Cancer Genome Atlas database. Subsequently, two stable NSCLC cell lines with hnRNPAB knockdown were constructed and the effects of hnRNPAB silencing on cell viability, migration, invasion and epithelial-mesenchymal transition (EMT) were identified. Genes associated with hnRNPAB expression in NSCLC were screened using the Linked Omics database and verified by quantitative real-time PCR (RT-qPCR). The database analysis indicated that hnRNPAB was mainly expressed in the nucleus of NSCLC cells. Compared with the normal tissues, hnRNPAB expression was overexpressed in NSCLC tissues and was closely associated with the overall survival, sex, tumor-node-metastases classification, and poor prognosis of patients with lung adenocarcinoma. Functionally, knockdown of hnRNPAB inhibited the proliferation, migration, invasion and EMT of NSCLC cells and arrested the cell cycle at G 1 phase. Mechanistically, the bioinformatics analysis and RT-qPCR verification demonstrated that hnRNPAB knockdown led to a significant expression change of genes associated with tumorigenesis. In conclusion, the present study indicated that hnRNPAB played an important role in the malignant transformation of NSCLC, supporting the significance of hnRNPAB as a novel potential therapeutic target for the early diagnosis and prognosis of NSCLC.

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“…According to reports [2], there are about 18.1 million new cancer cases and 9.6 million cancer deaths in the world, among which lung cancer new cases account for 11.6% and death cases account for 18.4%, ranking first in the mortality rate of major tumors. Surgery is the first choice for early-stage lung cancer, but patients are often accompanied by incision pain, cough, and psychological stress after surgery, which seriously affects the recovery of pulmonary rehabilitation and quality of life [3].…”

Section: Introductionmentioning

confidence: 99%

5E-led hospital-community-family care in patients with lung cancer surgery: it does work

Jiang

Sun

et al. 2023

Arch Med Sci

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IntroductionPostoperative pulmonary rehabilitation is a very important part in the treatment and nursing care of patients with lung cancer. We aimed to evaluate the effects of 5E (encouragement, education, exercise, employment and evaluation)-led hospital-community-family care model in patients with lung cancer.Material and methodsPatients with lung cancer undergoing surgery treatment in our hospital from January 1, 2021 to February 15, 2022 were selected. The patients were randomly assigned to the control and 5E group. The cardio-pulmonary function, quality of life and psychosocial adjustment level were evaluated and compared.ResultsA total of 154 patients with lung cancer involving 78 patients in the control group and 76 patients in the 5E groups were included. There were significant differences in the forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) at the one month, three months and six months follow-up between two group (all p<0.05). There were significant differences in the FEV1/FVC and peak expiratory flow (PEF) at six months follow-up between control group and 5E group (all p<0.05). There were significant differences in the 6 min walking test (6MWT), World Health Organization Quality of Life-100 Scale (WHOQOL-100) score and Self-report Psycho-social Adjustment to Illness Scale (PAIS-SR) score at the one month, three months and six months follow-up between two groups (all p<0.05).Conclusions5E-led hospital-community-family care model is beneficial to improve the cardiopulmonary function and quality of life in patients with lung cancer, which may worth promoting and using in clinical care of patients with lung cancer.

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Lung Cancer

Cited by 131 publications

References 25 publications

Association of lung-intestinal microecology and lung cancer therapy

Association of lung-intestinal microecology and lung cancer therapy

HnRNPAB is an independent prognostic factor in non‑small cell lung cancer and is involved in cell proliferation and metastasis

5E-led hospital-community-family care in patients with lung cancer surgery: it does work

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