Lung disease at high altitude

Stream, Joshua O.; Luks, Andrew M.; Grissom, Colin K.

doi:10.1586/ers.09.51

Cited by 33 publications

(25 citation statements)

References 171 publications

(181 reference statements)

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“…This supports the fact that COPD-BS and COPD-TS could represent different phenotypes of COPD [2,3]. It is important to note that in this study, most of our patients were hypoventilators and hypoxemic, all women showed a FEV1% prediction due to the height of Mexico City (~2240 m above sea level), which has effect on the functional capacities of the pulmonary and cardiovascular systems, and consequently the oxygen flow rate [19,20].…”

Section: Discussionsupporting

confidence: 70%

Participation of the miR-22-HDAC4-DLCO Axis in Patients with COPD by Tobacco and Biomass

et al. 2019

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Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation and systemic inflammation. The main causes of COPD include interaction between genetic and environmental factors associated with tobacco smoking (COPD-TS) and/or exposure to biomass smoke (COPD-BS). Several microRNAs (miRNAs) control posttranscriptional regulation of COPD-TS associated gene expression. The miR-22-HDAC4-IL-17 axis was recently characterized. It is still unknown, however, whether this axis, participates in COPD-BS. To investigate, 50 patients diagnosed with severe-to-very severe COPD GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages III/IV, were recruited, 25 women had COPD-BS (never smokers, exposed heavily to BS) and 25 had COPD-TS. Serum levels of miRNA-22-3p were measured by RT (Reverse Transcription)-qPCR, while the concentration of HDAC4 (Histone deacetylase 4) was detected by ELISA. Additionally, we looked for association between serum HDAC4 and DLCOsb (Single-breath diffusing capacity of the lung for carbon monoxide), as % of predicted by age, height, and gender, one of the main differences described between COPD-BS and COPD-TS. Women with COPD-BS were older and shorter and had a higher DLCOsb %P (percent predicted) compared to COPD-TS. Serum miR-22-3p was downregulated in COPD-BS relative to COPD-TS. In contrast, the concentration of HDAC4 was higher in COPD-BS compared to COPD-TS. Furthermore, a positive correlation between serum HDAC4 levels and DLCOsb %P was observed. We concluded that the miR-22-HDAC4-DLCO axis behaves differently in patients with COPD-BS and COPD-TS.

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Section: Discussionsupporting

confidence: 70%

Participation of the miR-22-HDAC4-DLCO Axis in Patients with COPD by Tobacco and Biomass

et al. 2019

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“…10 It is known that deterioration of gas exchange will be impaired by exposure to hypoxic environment in patients with COPD. 11 In this study, hemoglobin, hematocrit, MPV, WBC, neutrophil count, neutrophil percentage, NLR and PLR were higher in patients living at high altitude.…”

Section: Discussionsupporting

confidence: 46%

Comparison of complete blood counts of stable COPD patients at two different altitude in Turkey.

Perinçek¹,

Avcı²,

Yılmam³

2019

TPMJ

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Introduction: The aim of this study was to evaluate how altitude difference affects complete blood count (CBC) in patients with stable Chronic Obstructive Pulmonary Disease (COPD). Study Design: Cross-sectional study. Setting: Department of Pulmonology, Kars Harakani State Hospital (Group 1) and Samsun Chest Diseases and Thoracic Surgery Hospital (Group 2), Turkey. Period: Six months i.e. from March to September 2018. Material and Methods: A total of 400 patients (200 female, 200 male) with stable COPD were included. For each group, 100 female and 100 male patients were randomly selected from hospitals. Age, BMI (kg/m2), comorbidity, smoking status, CBC were evaluated. Hemoglobin, hematocrit, WBC, MPV, platelet, lymphocyte count and percentage, platelet/lymphocyte rate (PLR), neutrophil count and percentage, neutrophil /lymphocyte rate (NLR), eosinophil count and percentage, PDW, PCT were recorded. Results: Patients living at high altitude were significantly older, had lower weight and had lower FEV1 levels. COPD stages of Group 1 patients were more severe (p<0.001). There were no moderate COPD patients in this group and the patients had fewer comorbidities (43%). Hemoglobin, hematocrit, MPV, WBC, neutrophil count and percentage, NLR and PLR were significantly higher in Group 1 (p<0.001). PDW, PCT, lymphocyte count and percentage, eosinophil count and percentage were significantly higher in Group 2 patients (p<0.001). Conclusion: Hemoglobin, hematocrit, MPV, WBC, neutrophil count and percentage, NLR and PLR were higher in patients living at high altitude. PDW, PCT, lymphocyte count and percentage, eosinophil count and percentage were significantly higher in patients living at low altitude.

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“…In addition, several studies confirm that respiratory infection is a common health problem at high altitude compared to the lowlands. [38][39][40] The use of data with large sample size and considering several explanatory variables make this study appealing. Moreover, the use of multilevel analysis is another strength of this study.…”

Section: Discussionmentioning

confidence: 99%

<p>Determinants of Acute Respiratory Infection Among Children in Ethiopia: A Multilevel Analysis from Ethiopian Demographic and Health Survey</p>

Anteneh¹,

Hassen²

2020

IJGM

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Background: Acute respiratory infection (ARI) is one of the leading public health challenges among children in low-and middle-income countries. Child mortality due to ARI is disproportionately higher in African regions. In Ethiopia, an encouraging progress in the reduction of ARI was observed until 2010, however, since then the national prevalence is unchanged. There is limited information for the persistently higher prevalence of the infection. Therefore, the aim of this study was to determine regional variations and identify factors associated with the infection. Methods: This study used data from the Ethiopian Demographic and Health Survey (EDHS) conducted in 2016. The analysis used information from 10,006 children. A twolevel logistic regression analysis was used to consider the cluster random effect. Results: Out of 10,006 children included, 15.9%, 8.9%, and 8.8% reported cough, short rapid breaths, and chest complaint respectively two weeks before the survey, making the overall prevalence of ARI 8.8%. Children aged six to 11 years (adjusted odds ratio (AOR)=1.466, 95% CI: 1.143-1.881), and 12 to 23 (AOR=1.390, 95%CI: 1.109-1.742), small birth size (AOR=1.387, 95%CI), and animal dung as cooking fuel (AOR=1.904, 95%CI: 1.152-3.146) are significantly associated with higher odds of ARI in the final multilevel modeling. The AOR (95%CI) for ARI for differing levels of altitude were: 1000 to 2000, 1.805 (1.403-2.483); 2000 to 3000, 1.882 (1.427-2.483); above 3000, 2.24 (1.023-4.907). Conclusion: ARI is still a significant public health problem in Ethiopia among children underfive, with a huge variation in the burden across the regional states. Age of children, birth size, household cooking fuel, and altitude above sea level were important variables. Therefore, regional governments, health-care workers and concerned organizations should give emphasis to minimize ARI and the consequences associated with the disease.

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Lung disease at high altitude

Cited by 33 publications

References 171 publications

Participation of the miR-22-HDAC4-DLCO Axis in Patients with COPD by Tobacco and Biomass

Participation of the miR-22-HDAC4-DLCO Axis in Patients with COPD by Tobacco and Biomass

Comparison of complete blood counts of stable COPD patients at two different altitude in Turkey.

<p>Determinants of Acute Respiratory Infection Among Children in Ethiopia: A Multilevel Analysis from Ethiopian Demographic and Health Survey</p>

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