Lung disease in patients with common variable immunodeficiency

Lopez, Alejandra; Paolini, María Virginia; Romero, Diego S. Fernández

doi:10.1016/j.aller.2020.04.001

Cited by 8 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ILD is among the more frequent non-infectious complications of CVID, reported in 15%-60% of patients (7,9,14,(21)(22)(23). Clinical symptoms and high-resolution computed tomography (HRCT) findings of ILD can appear before or after CVID diagnosis (24,25).…”

Section: Interstitial Lung Disease In Common Variable Immune Deficienmentioning

confidence: 99%

Histology of Interstitial Lung Disease in Common Variable Immune Deficiency

et al. 2020

View full text Add to dashboard Cite

Interstitial lung disease (ILD) is an important non-infectious complication in several primary immune deficiencies. In common variable immune deficiency (CVID) it is associated with complex clinical phenotypes and adverse outcomes. The histology of ILD in CVID is heterogeneous and mixed patterns are frequently observed within a single biopsy, including non-necrotising granulomatous inflammation, lymphoid interstitial pneumonitis, lymphoid hyperplasia, follicular bronchiolitis, organizing pneumonia, and interstitial fibrosis; ILD has to be differentiated from lymphoma. The term granulomatous-lymphocytic interstitial lung disease (GLILD), coined to describe the histopathological findings within the lungs of patients with CVID with or without multisystem granulomata, is somewhat controversial as pulmonary granulomata are not always present on histology and the nature of infiltrating lymphocytes is variable. In this mini review we summarize the literature on the histology of CVID-related ILD and discuss some of the factors that may contribute to the inter- and intra- patient variability in the histological patterns reported. Finally, we highlight areas for future development. In particular, there is a need for standardization of histological assessments and reporting, together with a better understanding of the immunopathogenesis of CVID-related ILD to resolve the apparent heterogeneity of ILD in this setting and guide the selection of rational targeted therapies in different patients.

show abstract

Section: Interstitial Lung Disease In Common Variable Immune Deficienmentioning

confidence: 99%

Histology of Interstitial Lung Disease in Common Variable Immune Deficiency

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Pulmonary function tests (PFT) as assessment tools were reported in 40 studies ( 5 , 13 , 15 – 18 , 20 – 24 , 27 , 28 , 30 – 36 , 38 – 45 , 49 , 52 – 54 , 56 , 57 , 59 , 60 , 62 – 64 , 69 ), and included spirometry, measurement of diffusion capacity and assessment of static lung volumes (i.e., total lung capacity (TLC), and residual volume (RV)). Two studies reported PFT abnormalities as potential diagnostic criteria for CVID-ILD in addition to CT ( 64 , 65 ).…”

Section: Resultsmentioning

confidence: 99%

“…Thirty-one case reports and case series reported the use of CT in the diagnostic work up (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45). Thirteen observational studies relied primarily on CT as their only criteria for CVID-ILD (2,23,27,(46)(47)(48)(49)(50)(51)(52)(53)(54)(55), while 13 studies required either histological PRISMA flow diagram of study selection process. From: (11).…”

Section: Radiologymentioning

confidence: 99%

Diagnostic testing for interstitial lung disease in common variable immunodeficiency: a systematic review

et al. 2023

View full text Add to dashboard Cite

IntroductionCommon variable immunodeficiency related interstitial lung disease (CVID-ILD, also referred to as GLILD) is generally considered a manifestation of systemic immune dysregulation occurring in up to 20% of people with CVID. There is a lack of evidence-based guidelines for the diagnosis and management of CVID-ILD.AimTo systematically review use of diagnostic tests for assessing patients with CVID for possible ILD, and to evaluate their utility and risks.MethodsEMBASE, MEDLINE, PubMed and Cochrane databases were searched. Papers reporting information on the diagnosis of ILD in patients with CVID were included.Results58 studies were included. Radiology was the investigation modality most commonly used. HRCT was the most reported test, as abnormal radiology often first raised suspicion of CVID-ILD. Lung biopsy was used in 42 (72%) of studies, and surgical lung biopsy had more conclusive results compared to trans-bronchial biopsy (TBB). Analysis of broncho-alveolar lavage was reported in 24 (41%) studies, primarily to exclude infection. Pulmonary function tests, most commonly gas transfer, were widely used. However, results varied from normal to severely impaired, typically with a restrictive pattern and reduced gas transfer.ConclusionConsensus diagnostic criteria are urgently required to support accurate assessment and monitoring in CVID-ILD. ESID and the ERS e-GLILDnet CRC have initiated a diagnostic and management guideline through international collaboration.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022276337.

show abstract

CRIF1 promotes the progression of non-small-cell lung cancer by SIRT3- mediated deacetylation of PYCR1

Wang

Xie

et al. 2022

J Mol Histol

View full text Add to dashboard Cite

Lung disease in patients with common variable immunodeficiency

Cited by 8 publications

References 26 publications

Histology of Interstitial Lung Disease in Common Variable Immune Deficiency

Histology of Interstitial Lung Disease in Common Variable Immune Deficiency

Diagnostic testing for interstitial lung disease in common variable immunodeficiency: a systematic review

CRIF1 promotes the progression of non-small-cell lung cancer by SIRT3- mediated deacetylation of PYCR1

Contact Info

Product

Resources

About