Lung function and airway inflammation monitoring after hematopoietic stem cell transplantation

Abstract

There was a progressive loss in lung function after HSCT, featuring a restrictive pattern. Myeloablative conditioning was associated with early rise of sputum neutrophils and greater alteration in lung function over the first year.

Short-Term Variation of Lung Function and Airway Inflammation in Children and Adolescents with Bronchiolitis Obliterans

“…In accord with previous data, our cohort of clinically stable BO patients showed a pronounced neutrophilic inflammation with increased levels of IL-1, IL-6 and IL-8 in induced sputum despite stable lung function. Our findings in the context of BO are in keeping with earlier trials measuring neutrophils in BAL [26], in biopsies after lung transplantation [27] and in sputum after stem cell transplantation [28]. The reason why this ongoing neutrophilic inflammation does not lead to quick decline in lung function is unknown; however, the continuing inflammation offers an explanation of why affected patients do not recover.…”

Increased production of TGF-β1 from sputum cells of COPD: Relationship with airway obstruction

“…Each subject underwent a lung function and Diffusion for carbon monoxide (DLCO) assessment as previously described [16] and according to ATS/ERS standard criteria [17][18][19].…”

Sputum cytokine levels in patients undergoing hematopoietic SCT and comparison with healthy subjects and COPD: a pilot study

“…1 In a previous paper, we described the lung function status and the airway inflammatory profile of patients after HSCT using exhaled nitric oxide and induced sputum. 2 The principal observation was a progressive appearance of a restrictive lung function defect associated with a persistent airway neutrophilic inflammation after HSCT.…”