Lung Function and Telomere Relative Length in Clean-Up Workers of Chornobyl NPP Accident in a Remote Post-Accident Period

Shvaiko, Liudmyla; Bazyka, Kostiantyn; Sushko, Viktor; Ilienko, I.; Bazyka, Dimitry

doi:10.33145/2304-8336-2019-24-503-515

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…Forty-one (41) were retained after the reading of titles and abstracts. Twenty-six (26) of these were excluded due to lacking eligibility criteria: eight studies were excluded as a result of statistically significant differences in age between COPD patients and controls [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]; three were excluded due to the investigation of biomarkers in lung or muscular tissue [ 30 , 31 , 32 ]; five studies had no control group [ 17 , 33 , 34 , 35 , 36 ]; three did not report the results of statistical testing for discrepancies in age between COPD patients and controls [ 37 , 38 , 39 ]; and one did not perform comparisons [ 40 ]. Two articles employed a study design that was inconsistent with the stated eligibility criteria [ 41 , 42 ].…”

Section: Resultsmentioning

confidence: 99%

Immunosenescence and Inflammation in Chronic Obstructive Pulmonary Disease: A Systematic Review

Ramos Jesus,

Correia Passos,

Miranda Lopes Falcão

et al. 2024

JCM

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Background/Objectives: Chronic Obstructive Pulmonary Disease (COPD) is a disease of premature aging, characterized by airflow limitations in the lungs and systemic chronic inflammation. This systematic review aimed to provide a systematic overview of immunosenescence and inflammation in Chronic Obstructive Pulmonary Disease (COPD). Methods: The PubMed, Science Direct, Scopus, Cochrane Library, and Web of Science databases were searched for studies on markers of immunosenescence. Observational studies comparing patients with COPD to individuals without disease were evaluated, considering the following markers: inflammation and senescence in COPD, naïve, memory, and CD28null T cells, and telomere length in leukocytes. Results: A total of 15 studies were included, eight of which were rated as high quality. IL-6 production, telomere shortening, and the higher frequencies of CD28null T cells were more prominent findings in the COPD studies analyzed. Despite lung function severity being commonly investigated in the included studies, the importance of this clinical marker to immunosenescence remains inconclusive. Conclusions: The findings of this systematic review confirmed the presence of accelerated immunosenescence, in addition to systemic inflammation, in stable COPD patients. Further studies are necessary to more comprehensively evaluate the impact of immunosenescence on lung function in COPD.

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Section: Resultsmentioning

confidence: 99%

Immunosenescence and Inflammation in Chronic Obstructive Pulmonary Disease: A Systematic Review

Ramos Jesus,

Correia Passos,

Miranda Lopes Falcão

et al. 2024

JCM

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“…A study conducted on 113 clean-up workers of Chornobyl nuclear power plant (NPP) accident showed a trend towards reducing the relative telomere length in clean-up workers who suffer from COPD and exposed to doses ranged 100 to 500 mSv and above 500 mSv. In this study, the dose in clean-up workers ranged from 1.0 to 880 mSv (330.4 ± 317.7 (M ± SD)) [10].…”

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confidence: 76%

Space Medicine: Why Do Recently Published Papers about Telomere Length Alterations Increase our Uncertainty Rather than Reduce it?

Bevelacqua¹,

Welsh

Mortazavi

et al. 2021

J Biomed Phys Eng

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There is a growing interest in examining alterations in telomere length as a reliable biomarker of general health, as well as a marker for predicting later morbidity and mortality. Substantial evidence shows that telomere length is associated with aging; telomere shortening acts as a “counting mechanism” that drives replicative senescence by limiting the mitotic potential of normal (but not malignant) cells. In this Correspondence, we attempt to answer the question of why recently published papers about telomere length alterations increase our uncertainty rather than reduce it. This discussion includes three major research areas regarding telomere length: environmental stressors, aging, and life span. Our review suggests that activation of telomerase activity due to stressors in space might be a double-edged sword with both favorable and unfavorable consequences. The selection of an effect’s consequence must clearly elucidate the experimental conditions as well as associated stressors. In this Correspondence, we attempt to answer the question of why recently published papers about telomere length alterations increase our uncertainty rather than reduce it. The selection of an effect’s consequence must clearly elucidate the experimental conditions as well as associated stressors. Both positive and negative consequences must be clearly addressed in order to bolster the conclusions, as well as identify future research directions.

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Relative Telomere Length of Peripheral Blood Lymphocytes and Structural and Functional State of the Left Ventricle Myocardium in Clean-Up Workers of the Chornobyl Accident Who Suffered From Stenotic Coronary Atherosclerosis

Belyi¹,

Ilyenko²,

Nastina³

et al. 2021

Probl Radiac Med Radiobiol

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The objective was to analyze the relative telomere length (RTL) of peripheral blood lymphocytes depending on myocardium structural and functional state in emergency workers (EW) of the Chornobyl accident who suffered from coronary arteries stenotic atherosclerosis. Materials and methods. There were examined 60 male EW who operated at the Chornobyl nuclear power plant at 1986 and 25 male non-irradiated persons (control group – CG) with coronary heart disease (CHD). Everyone EW and CG patients were almost healthy before the accident. During the period 2016–2021, they underwent a comprehensive clinical and laboratory examination, echodopplercardiographic examination and determination of RTL by fluorescent hybridization in situ using laser flow cytometry. Results. EW almost did not differ from CG according to its clinical characteristics, the presence of risk factors, indices of systolic and diastolic heart functions, as well as RTL. The analysis of variance showed that RTL was influenced by the fact of irradiation in combination with obesity (p = 0.020). At normal body weight, RTL average value in CG was significantly higher than in EW (p = 0.023). According to the results of hierarchical cluster analysis of two variables as RTL and end-diastolic volume normalized by body surface area (EDV/BSA), EW and CG patients together were divided into two subgroups. The first subgroup (1st cluster) differed from the second (2nd cluster) by significantly larger average values of left ventricle (LV) EDV and end-systolic volume (ESV) as well as EDV/BSA and ESV/BSA, LV myocardial mass (MM) and MM/BSA, reduced ejection fraction (EF). In patients of the 1st cluster telomeres were significantly shorter than in the 2nd one (10,3 ± 1.7 vs. 14.3 ± 2.0 at p = 0.000). The increase of myocardial mass and LV wall thickness caused the development of its hypertrophy. The number of people with hypertrophy LV was significantly higher among patients of the 1st cluster (91.6 vs. 67.2 %, p < 0.001) due to eccentric hypertrophy LV. Accordingly, concentric hypertrophy LV was more common among patients in the 2nd cluster (24.6 vs. 4.2 % at p < 0.01). Patients of the 1st cluster was characterized by a more severe course of heart failure. Conclusions. In patients who suffered from CHD with stenotic atherosclerosis of the coronary arteries and were exposed to radiation 30–35 years earlier, having normal body weight, there was a reduction in telomere. Hierarchical cluster analysis proved to be a good tool that allows by the value of RTL and EDV/BSA to separate the group of patients with the most severe clinical course of CHD and LV systolic dysfunction among patients with the same pathology. Key words: emergency workers of the accident at the Chornobyl NPP, radiation exposure, coronary heart disease, stenotic atherosclerosis of the coronary arteries, myocardial infarction, relative telomere length, end-diastolic volume.

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Lung Function and Telomere Relative Length in Clean-Up Workers of Chornobyl NPP Accident in a Remote Post-Accident Period

Cited by 4 publications

References 16 publications

Immunosenescence and Inflammation in Chronic Obstructive Pulmonary Disease: A Systematic Review

Immunosenescence and Inflammation in Chronic Obstructive Pulmonary Disease: A Systematic Review

Space Medicine: Why Do Recently Published Papers about Telomere Length Alterations Increase our Uncertainty Rather than Reduce it?

Relative Telomere Length of Peripheral Blood Lymphocytes and Structural and Functional State of the Left Ventricle Myocardium in Clean-Up Workers of the Chornobyl Accident Who Suffered From Stenotic Coronary Atherosclerosis

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