Lung function in HIV- infected adolescents on antiretroviral therapy in Cape Town, South Africa

Githinji, Leah; Gray, Diane; Hlengwa, Sipho; Zar, Heather J.

doi:10.1183/13993003.congress-2016.pa674

Cited by 3 publications

(5 citation statements)

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“…Our findings revealed that the mean percentage of predicted FVC was significantly reduced in PLHIV participants than in HIV-negative respondents. This observation aligns with studies conducted in Cape Town, South Africa, and Amsterdam (18, 19). The concurrent decline in FEV1 and FVC with the slight preservation of the FEV1/FVC ratio was observed in our study.…”

Section: Discussionsupporting

confidence: 93%

Pulmonary function tests and their associated factors in people living with HIV at Jimma medical center; Ethiopia: a comparative cross-sectional study

Azezew,

Gobena,

Mengstie

et al. 2023

Front. Reprod. Health

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BackgroundPeople living with HIV (PLHIV) have a greater risk of developing respiratory disorders. The problems are linked to poor socio-economic status, high viral load, low CD4 counts, and antiretroviral therapy. Despite the high prevalence of respiratory disorders, the association between HIV infection and pulmonary function status, as well as the associated factors, is not well established in resource-limited countries.MethodsA comparative cross-sectional study was conducted from September 24 to October 15 2020 at Jimma Medical Center among people living with HIV who were arranged into an age–sex-matched comparison group. Data were collected using a pretested structured questionnaire administered via face-to-face interviews. The collected data included socio-demographic, respiratory, HIV infection, and substance use variables. Pulmonary function tests were conducted using an SP10 spirometer. The collected data were entered and analyzed using SPSS version 26. Independent t-test and multiple linear regressions were carried out to identify factors associated with the pulmonary function status of the study participants.ResultsA total of 96 PLHIV and 96 matched control individuals participated in the study. The mean of pulmonary function test parameters among the PLHIV respondents was FVC (l) (67.35 ± 19.12, p0.003), FEV1s (l) (61.76 ± 16.04, p0.001), and PEFR (50.14 ± 23.32, p0.001), with a significant lowering in the study group. Female sex, respiratory symptoms, duration of HIV, duration of treatment, and khat chewing were associated with lowered FEV1s (l) (p < 0.05) in HIV-positive respondents.ConclusionPLHIV had significantly lower mean lung function parameters than HIV-uninfected participants. As a result, health providers should screen HIV-positive patients with respiratory symptoms, prolonged duration of HIV infection, prolonged treatment, and khat chewing for non-infectious lung disorders while treating them.

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Section: Discussionsupporting

confidence: 93%

Pulmonary function tests and their associated factors in people living with HIV at Jimma medical center; Ethiopia: a comparative cross-sectional study

Azezew,

Gobena,

Mengstie

et al. 2023

Front. Reprod. Health

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“…History of TB is the negative predictor of FVC (l), FVC%, and FEF 25-75 . This study is in line with a study done in South Africa [10,14,33]. The reason for such observation is in TB endemic area TB follows the footsteps of HIV and vice versa [33].…”

Section: Discussionsupporting

confidence: 91%

“…Our ndings revealed that the mean of FVC was signi cantly reduced in RVI study participants than non-RVI respondents. This observation is in line with a study done in Cape Town of South Africa and Amsterdam [9,14]. This might be linked to the fact that HIV had been associated with the rapid development of sarcopenia [9].…”

Section: Discussionsupporting

confidence: 89%

“…The reason for this observation is quite multifactorial, in the aftermath of HAART provision, RVI patients are living with a low level of viremia. This consistent low level of viremia induces persistent long-term in ammation which causes oxidative stress, disruption of mucociliary clearance mechanism, sarcopenia, airway remodeling, and undernutrition [9,14,21,27]. On top of this, the duration of HIV infection is associated with the reduction of serum alpha-1-antitrypsin concentrations which are serine protease inhibitors (protect extracellular matrix of alveolar parenchyma) [28,29].…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary Function Tests and Their Associated Factors in HIV-infected Patients at Jimma Medical Center; Ethiopia: A Comparative Cross-Sectional Study

Teshome¹,

Gobena

Asmamaw³

et al. 2021

Preprint

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BackgroundHIV-infected persons have a greater risk of developing respiratory disorders. Poor socio-economic status, High viral load, low CD4 counts, and anti-retroviral therapy are linked with the problems. Despite its high prevalence the association between retroviral infection and pulmonary function status as well as their associated factors has not yet well established in resource-scarce countries in general and study setting in particularMethodsA comparative cross-sectional study was conducted from September 24 to October 15 of 2020 at Jimma Medical Center among HIV-positive patients and matched control group. Data were collected using a pretested structured questionnaire administered via face-to-face interview. The collected data included Socio-demographic, respiratory, retroviral infection, and substance use related. Pulmonary function tests were also conducted using SP10 spirometer. Collected data were entered and analyzed using SPSS version 26. Independent t-test and multiple linear regressions were carried out to identify factors independently associated with the pulmonary function status of the study participants while controlling for potential confounders.ResultsOne hundred ninety two HIV-positive patients and matched control individuals participated in the study. A mean pulmonary function test parameters among HIV-infected participants were FVC (l) (2.957±0.792, p0.006), FEV (l) (2.289±0.593, p<0.001), and PEFR (l) (4.258±2.039, p<0.001) with a significant declined in the group. Respiratory symptom, history of pulmonary TB, duration of living with RVI, duration of treatment, and current CD4 cell count were significant predictors of pulmonary function test indices(p<0.05) in HIV infected respondents.ConclusionA significant reduction in mean pulmonary function parameters were observed among HIV-positive participants in comparison to non-RVI participants. A strong association was observed between pulmonary function status of HIV-infected patients and current CD4 count, duration of living with RVI, duration of treatment, and history of PTB. Therefore, due consideration in screening, diagnosing, and managing noninfectious lung diseases should be given by health professionals while treating HIV-infected patients.

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“…The aim of this study was to investigate the spectrum and determinants of lung function in HIV-infected adolescents on antiretroviral therapy in Cape Town, South Africa. Some of the results of these studies have been previously reported in the form of an abstract (19).…”

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confidence: 96%

Lung Function in South African Adolescents Infected Perinatally with HIV and Treated Long-Term with Antiretroviral Therapy

et al. 2017

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Lung function in HIV- infected adolescents on antiretroviral therapy in Cape Town, South Africa

Cited by 3 publications

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Pulmonary function tests and their associated factors in people living with HIV at Jimma medical center; Ethiopia: a comparative cross-sectional study

Pulmonary function tests and their associated factors in people living with HIV at Jimma medical center; Ethiopia: a comparative cross-sectional study

Pulmonary Function Tests and Their Associated Factors in HIV-infected Patients at Jimma Medical Center; Ethiopia: A Comparative Cross-Sectional Study

Lung Function in South African Adolescents Infected Perinatally with HIV and Treated Long-Term with Antiretroviral Therapy

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