Lung metastases from sarcoma: multidisciplinary approach—a narrative review

Gherzi, Lorenzo; Ferrari, M; Pardolesi, Alessandro

doi:10.21037/asj-21-68

Cited by 3 publications

(2 citation statements)

References 54 publications

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“…Despite its low incidence-increasing from 3 cases per 100,000 people in 2013 to three 3 per 45,000 currently-UPS demonstrates a worrying trend towards a gradual increase in occurrence [6,9]. The primary sites for metastatic spread are typically the lungs, as demonstrated in our case report, and less frequently, the liver [4,10].…”

Section: Discussionmentioning

confidence: 46%

A Detailed Examination of Retroperitoneal Undifferentiated Pleomorphic Sarcoma: A Case Report and Review of the Existing Literature

Balovic,

Stojanovic,

Radovanovic

et al. 2024

JCM

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This detailed review focuses on retroperitoneal undifferentiated pleomorphic sarcoma (UPS), a particularly aggressive soft-tissue sarcoma that poses unique diagnostic and therapeutic challenges due to its rarity and complex presentation. By documenting a new case of retroperitoneal UPS and conducting a comprehensive review of all known cases, this article aims to expand the existing body of knowledge on the epidemiology, molecular pathogenesis, and treatment strategies associated with this rare disease. The complexity of diagnosing UPS is emphasized given that it rarely occurs in the retroperitoneal space and its histological and molecular complexity often complicates its recognition. This review highlights the need for specialized diagnostic approaches, including advanced imaging techniques and histopathological studies, to accurately diagnose and stage the disease. In terms of treatment, this paper advocates a multidisciplinary approach that combines surgery, radiotherapy and chemotherapy and tailors it to individual patients to optimize treatment outcomes. This review highlights case studies that illustrate the effectiveness of surgical intervention in the treatment of these tumors and emphasize the importance of achieving clear surgical margins to prevent recurrence. Furthermore, this review discusses the potential of new molecular targets and the need for innovative therapies that could bring new hope to patients affected by this challenging sarcoma.

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Section: Discussionmentioning

confidence: 46%

A Detailed Examination of Retroperitoneal Undifferentiated Pleomorphic Sarcoma: A Case Report and Review of the Existing Literature

Balovic,

Stojanovic,

Radovanovic

et al. 2024

JCM

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“…The role of metastasectomy in adults is currently debated, and data have mainly been collected and analyzed for some kinds of solid tumors. Currently, it is consolidated for primary bone and soft tissue sarcomas; several studies have shown good results, increasing overall survival and disease-free survival [ 2 , 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Case for Pulmonary Metastasectomy—Clinical Practice Narrative Review and Commentary

Scanagatta,

Ancona,

Cagnetti

et al. 2024

Life

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Pulmonary metastasectomy has become a well-established procedure for patients with certain types of solid tumors. Patients are usually scheduled for staged lung metastasectomy in case of primary tumor control, the absence of distant non-lung metastases, and when complete resection is achievable. Nodules are removed with precision resection in order to ensure radical resection with minimal margins; this technique permits good oncological results, preserving the surrounding pulmonary parenchyma and causing minimal distortion compared to staplers. When possible, anatomical resections should be avoided since they are not justified by real oncological advantages and, in the majority of cases, sacrifice too much healthy tissue, possibly leading to inoperability in the case of metachronous relapses. Thus, preserving the maximum amount of pulmonary parenchyma is crucial because repeated metastasectomies are possible and frequent, with no theoretical limits to the number of reinterventions. In our multidisciplinary board team, we support the role of pulmonary metastasectomy as a useful curative therapy, with acceptable morbidity and mortality, with indications to be discussed case-by-case.

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