Lung oxidative response after acute coal dust exposure

Pinho, Ricardo A.; Bonatto, Fernanda; Andrades, Michael Éverton; Frota, Mario Luiz Conte da; Ritter, Cristiane; Klamt, Fábio; Dal‐Pizzol, Felipe; Uldrich-Kulczynski, Jane M.; Moreira, José Cláudio Fonseca

doi:10.1016/j.envres.2003.10.006

Cited by 48 publications

(27 citation statements)

References 32 publications

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“…The exposure to mineral coal stimulates the production of the carbonyl groups (4) , and in this specific case, it can be softened by the regular practice of physical exercise, according to results showed in this study.…”

Section: Discussionmentioning

confidence: 88%

“…The changes in the lipoperoxidation markers are more frequent evidences observed into the pulmonary tissue after exposure to atmospheric pollutants (4) , and in the response to the physical exercise (26) . The results attained in our study show that the regular physical exercise presented a significant decrease in the pulmonary lipoperoxidation levels in rats exposed to the mineral coal after physical training (figure 1).…”

Section: Discussionmentioning

confidence: 99%

“…Probably such difference between these studies is due to the different types of muscular fibers used or the different training protocols or in the methods used to determine the enzymatic activity or even to the differentiated molecular adaptations (translational and post-translational modifications) in the CS adaptation during and post-physical training (22) . Recent studies (4,5,23,24) show that the pulmonary response by occupational and atmospheric pollutants such as the coal, causes a inflammatory chain-response mediated by the macrophage activation, and the recruitment of polymorphonuclear cells, cytosine, chymosin, and reactive Oxygen specimens (ROS). After inhaling these pollutants, the ROS production can be significantly increased, causing damages in the cellular constituents (2) .…”

Section: Discussionmentioning

confidence: 99%

“…), and zylazine (20 mg/kg of the body mass, i.d.) anesthetized, and they received direct administration by tracheal instillation of 3 mg/ 0.5 ml of saline or 0.5 ml of 0.9% saline solution once every three days for nine days, in a procedure adapted from the model described by Pinho and co-workers (4) . The animals were randomly divided in two groups with their respective controls: Trained (TR, n = 6), and Non-trained (NTR, n = 6).…”

Section: Methodsmentioning

confidence: 99%

“…Recent studies (1)(2)(3)(4) have shown that the pulmonary change after inhaling industrial particles is mediated mainly by the formation of reactive Oxygen specimens (ROS). According to Tao and co-workers (5) , such biochemical response leads to the macrophage activation and to the recruitment of polymorphonuclear cells that induce to the increase in the inflammatory mediators.…”

Section: Introductionmentioning

confidence: 99%

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Exercício físico regular diminui o estresse oxidativo pulmonar em ratos após exposição aguda ao carvão mineral

Pinho

Piazza

Tuon

et al. 2006

Rev Bras Med Esporte

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Several studies have pointed the regular low to moderate intensity physical exercise an important agent to combat the oxidant stress. The purpose of this study was to investigate the effect of the physical exercise in the pulmonary oxidant response after inhaling mineral coal dust. Twenty-four male Wistar rats (200-250 g) were randomly divided in two groups with their respective controls (trained, n = 6; non-trained, n = 6). All animals received mineral coal dust via tracheal instillation (saline 3 mg/0.5 ml, 3 days/ week for 3 weeks), or 0.5 ml of 0.9% saline solution. Forty-eight hours after the last instillation, the trained group was submitted to a progressive exercise program on treadmill for twelve weeks (up to 17 m.min , 10% inclination). Forty-eight hours after the last training session, every animal was killed by decapitation, and their lungs and soleus were surgically removed for later biochemical analysis. The citrate synthase activity was determined in the soleus muscle, and the damages on the lipids and proteins were assessed into the lungs by means of the TBARS concentration and by determining the carbonyl groups, respectively. The results show that the regular practice of physical exercises reduces significantly the present TBARS levels in trained rats, decreasing the oxidation levels in proteins of both groups compared to their respective controls. The results lead us to suggest that the regular physical exercise on treadmill is an agent capable to soften the pulmonary oxidant damages caused by inhaling mineral coal particles.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%