Lung Protection During Mechanical Ventilation in the Premature Infant

Williams, Emma; Greenough, Anne

doi:10.1016/j.clp.2021.08.006

Cited by 9 publications

(8 citation statements)

References 67 publications

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“…Lung mechanics can be monitored extensively by ventilatory graphics and describe the dynamic interplay between pressure, flow and volume. Indeed, in neonates, lung protective ventilation can be continuously adapted to disease states by close monitoring of pulmonary pressure–volume curves [ 48 , 49 ]. Furthermore, outcomes can be improved secondary to reduced patient–ventilator asynchrony and appropriate tidal volume monitoring in those requiring invasive ventilation [ 50 ].…”

Section: Group 75: Respiratory Disorders In Neonatal and Paediatric I...mentioning

confidence: 99%

ERS International Congress 2022: highlights from the Paediatrics Assembly

Ardura‐Garcia¹,

Kainz

Mallet

et al. 2023

ERJ Open Res

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This review has been prepared by the Early Career Members and Chairs of the European Respiratory Society (ERS) Assembly 7: Paediatrics. We here summarise the highlights of the advances in paediatric respiratory research presented at the ERS International Congress 2022. The eight scientific Groups of this Assembly cover a wide range of research areas, including respiratory physiology and sleep, asthma and allergy, cystic fibrosis (CF), respiratory infection and immunology, neonatology and intensive care, respiratory epidemiology, bronchology, and lung and airway developmental biology. Specifically, we report on abstracts presented at the congress on the effect of high altitude on sleep, sleep disorders, the hypoxic challenge test, and measurements of ventilation inhomogeneity. We discuss prevention of preschool wheeze and asthma, and new asthma medications. In children with CF, we describe how to monitor the effect of CF transmembrane conductance regulator modulator therapy. We present respiratory manifestations and chronic lung disease associated with common variable immunodeficiency. Furthermore, we discuss how to monitor respiratory function in neonatal and paediatric intensive care units. In respiratory epidemiology, we present the latest news from population-based and clinical cohort studies. We also focus on innovative and interventional procedures for the paediatric airway, such as cryotherapy. Finally, we stress the importance of better understanding the molecular mechanisms underlying normal and abnormal lung development.

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Section: Group 75: Respiratory Disorders In Neonatal and Paediatric I...mentioning

confidence: 99%

ERS International Congress 2022: highlights from the Paediatrics Assembly

Ardura‐Garcia¹,

Kainz

Mallet

et al. 2023

ERJ Open Res

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“…Atelectrauma results from ventilating at low lung volumes. This type of lung injury results from shear stress secondary to repeated alveolar collapse and expansion (RACE) [8,[46][47][48]. The very preterm infants are at high risk for RACE because they have difficulty maintaining their upper airway patency and FRC [49].…”

Section: Atelectraumamentioning

confidence: 99%

Ventilation-Induced Lung Injury (VILI) in Neonates: Evidence-Based Concepts and Lung-Protective Strategies

Thekkeveedu

El-Saie

Prakash

et al. 2022

JCM

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Supportive care with mechanical ventilation continues to be an essential strategy for managing severe neonatal respiratory failure; however, it is well known to cause and accentuate neonatal lung injury. The pathogenesis of ventilator-induced lung injury (VILI) is multifactorial and complex, resulting predominantly from interactions between ventilator-related factors and patient-related factors. Importantly, VILI is a significant risk factor for developing bronchopulmonary dysplasia (BPD), the most common chronic respiratory morbidity of preterm infants that lacks specific therapies, causes life-long morbidities, and imposes psychosocial and economic burdens. Studies of older children and adults suggest that understanding how and why VILI occurs is essential to developing strategies for mitigating VILI and its consequences. This article reviews the preclinical and clinical evidence on the pathogenesis and pathophysiology of VILI in neonates. We also highlight the evidence behind various lung-protective strategies to guide clinicians in preventing and attenuating VILI and, by extension, BPD in neonates. Further, we provide a snapshot of future directions that may help minimize neonatal VILI.

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“…Prematüre bebekler doğum sonrası yaşamını devam ettirebilmek ve dış dünyaya uyum sağlayabilmek için bir takım tıbbi desteğe gereksinim duymaktadır 2 . Bu desteklerin en başında solunum desteği gerekmektedir 3 . Solunum fonksiyonu yetersiz olan bebeklerde solunumu desteklemek amacıyla genellikle ventilatör kullanılmaktadır.…”

Section: Introductionunclassified

İnvaziv ve Noninvaziv Mekanik Ventilasyondaki Prematüre Bebeklerde Kronik Ağrının Değerlendirilmesi

Ertürk

Geçkil

2023

Hacettepe Üniversitesi Hemşirelik Fakültesi Dergisi

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Amaç: İnvaziv ve noninvaziv mekanik ventilasyondaki prematüre bebeklerin kronik ağrısını değerlendirmek amacıyla yürütülen bu çalışma tanımlayıcı olarak yapılmıştır. Gereç ve Yöntem: Bu araştırmanın örneklemini Yenidoğan Yoğun Bakım Ünitesi’nde yatan, gestasyon yaşları ≥25 hafta ve ≤ 36 hafta olan 110 prematüre bebek oluşturmuştur. Veriler bebeklerin özelliklerini belirlemek amacıyla Tanımlayıcı Bilgi Formu ve Yenidoğan Ağrı ve Rahatsızlık Ölçeği (EDIN) ile Şubat 2018- Nisan 2019 tarihleri arasında toplanmıştır. Veriler normal dağılıma uygunluk durumuna uygun testler ile analiz edilmiş ve önemlilik düzeyi p6 puan) tespit edilmiştir. Mekanik ventilasyon uygulanan prematüre bebeklerin yatış süresi ve mekanik ventilasyon uygulama süresi arttıkça kronik ağrı puanlarının arttığı tespit edilmiştir (p

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Lung Protection During Mechanical Ventilation in the Premature Infant

Cited by 9 publications

References 67 publications

ERS International Congress 2022: highlights from the Paediatrics Assembly

ERS International Congress 2022: highlights from the Paediatrics Assembly

Ventilation-Induced Lung Injury (VILI) in Neonates: Evidence-Based Concepts and Lung-Protective Strategies

İnvaziv ve Noninvaziv Mekanik Ventilasyondaki Prematüre Bebeklerde Kronik Ağrının Değerlendirilmesi

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