Lung radiofrequency ablation: post-procedure imaging patterns and late follow-up

Araújo-Filho, José de Arimateia Batista; Menezes, Raonne Souza Almeida Alves; Horvat, Natally; Panizza, Pedro Sergio Brito; Bernardes, João Paulo Giacomini; Damasceno, Rodrigo Sanford; Oliveira, Brunna Clemente; Menezes, Marcos Roberto de

doi:10.1016/j.ejro.2020.100276

Cited by 10 publications

(2 citation statements)

References 27 publications

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“…Recurrence was defined according to criteria presented in previous literature including GGN found at the edges of fibrosis lesions. 12 PFT findings included forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1%, maximal voluntary ventilation (MVV), and peak expiratory flow (PEF). Ablation volume (cm 3 ) was measured and recorded on postoperative day 3.…”

Section: Methodsmentioning

confidence: 99%

Factors Associated with Pulmonary Function Changes in Patients Undergoing Microwave Ablation for Pulmonary Ground-Glass Nodules

Peng

Gao

et al. 2022

Technol Cancer Res Treat

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Purpose: Microwave ablation has become an alternative treatment for pulmonary ground-glass nodules (GGN) and is widely accepted by clinicians. However, its effect on lung function remains unknown. Therefore, this retrospective study aimed to explore pulmonary function changes and associated risk factors in patients undergoing computed tomography (CT)-guided microwave ablation (MWA) for treating pulmonary GGN. Materials and Methods: Thirty-five patients diagnosed with pulmonary GGN on thin-layer chest CT and enhanced CT were examined. Patients unable or unwilling to undergo thoracoscopic surgery underwent CT-guided simultaneous percutaneous core needle biopsy and MWA. Pulmonary function tests (PFT) were performed before ablation and 3 days and 6 months post-ablation. Forced expiratory volume in one second (FEV1), FEV1%, forced vital capacity (FVC), maximal voluntary ventilation (MVV), and peak expiratory flow (PEF) values pre- and post-MWA were analysed. Linear regression analysis was used to examine the correlation between ablation volume and changes in PFT findings 3 days post-ablation. Associations between patient characteristics, rates of postoperative complications, and PFT findings were analysed. Results: Forty-eight lesions were completely ablated and examined intraoperatively. There were significant differences in pre- and post-operative PFT findings on day 3 but not at 6 months. The mean ablation volume after 3 days of 11.4 ± 6.3 cm3 was positively correlated with changes in FEV1, MVV, and PEF values. Patients’ age (mean, 59.4 ± 13.0 years) positively correlated with changes in PEF values. The rates of change in FVC and MVV values were significantly higher with multiple pulmonary nodules than with isolated pulmonary nodule. PFT findings were similar between patients who experienced or did not experience complications (eg, pneumothorax and pleural effusion). Conclusions: Pulmonary function could be impaired shortly after MWA. PFT findings may correlate with age, ablation volume, and number of ablated lesions. In most patients, pulmonary function returned to the preoperative state after 6 months.

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Section: Methodsmentioning

confidence: 99%

Factors Associated with Pulmonary Function Changes in Patients Undergoing Microwave Ablation for Pulmonary Ground-Glass Nodules

Peng

Gao

et al. 2022

Technol Cancer Res Treat

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“…MWA effectiveness was evaluated by CT scan within the first week after treatment. The ablation zone was the radiological region of the post-ablation change characterized by a solid or ground-glass opacity area around the tumor (13,14). According to standardization of terminology and reporting criteria for image-guided tumor ablation (15,16), "technique effectiveness" refers to a "complete ablation" of macroscopic tumor as evidenced by the imaging of a tumor covered by a larger solid or ground-glass opacity area (Figure 4).…”

Section: Follow-up Evaluationmentioning

confidence: 99%

Electromagnetic bronchoscopy guided microwave ablation for early stage lung cancer presenting as ground glass nodule

Bao¹,

Yu²,

Wang³

et al. 2021

Transl Lung Cancer Res

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Background: Patients with early-stage lung cancer are sometimes medically inoperable, and for patients with multiple primary lung cancers, surgical resection alone sometimes proves to be impractical. Local treatments like microwave ablation (MWA) are investigational alternatives for these patients. Most reported MWA procedures for lung cancers are performed percutaneously under CT guidance. MWA navigated by electromagnetic bronchoscopy (ENB) has been limitedly studied. In this study, we aimed to evaluate the safety and feasibility of MWA under ENB guidance in patients with inoperable early-stage lung cancers or multiple primary lung cancers which cannot be completely resected.Methods: From June 2019 to December 2020, preliminary attempts of ENB-guided MWA were made in five medically inoperable patients with a single early-stage lung cancer and ten patients with multiple primary lung cancers which were difficult to resect at the same time. For patients with concomitant pulmonary nodules which needed surgical resection, thoracoscopic resections were performed following ENB-guided MWA. The safety, feasibility, and technique effectiveness of treatments were evaluated.Results: ENB-guided MWA for 15 ground glass nodules (GGNs) in 15 patients was completed in accordance with the planned protocol. Biopsy of 13 GGNs showed malignancy. Five patients received simple ENB-guided MWA without simultaneous surgical resection and ten patients received simultaneous surgical resection for 13 concomitant pulmonary nodules. CT scan by the first postoperative week showed technique effectiveness of ablation for 11 nodules indicated for MWA. Four patients had mild complications after the procedure and recovered shortly after treatment.Conclusions: For medically inoperable patients with a single GGN manifesting early-stage lung cancer and patients with multiple primary early-stage lung cancers which cannot be resected at the same time, ENB-guided MWA might be a safe and feasible alternative local treatment, whether combined with surgical resection or not. However, large, prospective, randomized, multicenter studies are needed to confirm its role in the treatment of early-stage lung cancer.

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A comparative analysis of thermal ablation techniques in the treatment of primary and secondary lung tumors: a single-center experience

Grasso

Bernetti²,

Santucci³

et al. 2022

Radiol med

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Lung radiofrequency ablation: post-procedure imaging patterns and late follow-up

Cited by 10 publications

References 27 publications

Factors Associated with Pulmonary Function Changes in Patients Undergoing Microwave Ablation for Pulmonary Ground-Glass Nodules

Factors Associated with Pulmonary Function Changes in Patients Undergoing Microwave Ablation for Pulmonary Ground-Glass Nodules

Electromagnetic bronchoscopy guided microwave ablation for early stage lung cancer presenting as ground glass nodule

A comparative analysis of thermal ablation techniques in the treatment of primary and secondary lung tumors: a single-center experience

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