Lung ultrasonography as a direct measure of evolving respiratory dysfunction and disease severity in patients with acute pancreatitis

Skouras, Christos; Davis, Zoe A.; Sharkey, Joanne; Parks, Rowan W.; Garden, James; Murchison, John T; Mole, Damian J.

doi:10.1111/hpb.12515

Cited by 4 publications

(5 citation statements)

References 41 publications

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“…19–22 In pneumonia-caused ARDS, increasing age and comorbidities were associated with high risk of developing ARDS. Surprisingly, there were no statistically significant differences in age and comorbidities among SAP patients with or without ARDS in the present study, which was consistent with previous studies among patients with SAP 23,24 and AP, 16,25 indicating that age and comorbidities is not as much of a risk factor in SAP-related ARDS as in pneumonia-initiated ARDS. Although hypertriglyceridemia-induced AP has been reported to be associated with risk of lung failure compared with other etiologies, 16,26 the etiologies of SAP have no significant differences between the groups with or without ARDS.…”

Section: Discussionsupporting

confidence: 92%

A prediction model for acute respiratory distress syndrome among patients with severe acute pancreatitis: a retrospective analysis

Lin

Han

et al. 2022

Ther Adv Respir Dis

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Background: Acute respiratory distress syndrome (ARDS) is a severe complication among patients with severe acute pancreatitis (SAP), which may be associated with increased mortality in hospitalized patients. Thus, an effective model to predict ARDS in patients with SAP is urgently required. Methods: We retrospectively analyzed the data from the patients with SAP who recruited in Xiangya Hospital between April 2017 and May 2021. Patients meeting the Berlin definition of ARDS were categorized into the ARDS group. Logistic regression models and a nomogram were utilized in the study. Descriptive statistics, logistic regression models, and a nomogram were used in the current study. Results: Comorbidity of ARDS occurred in 109 (46.58%) of 234 patients with SAP. The SAP patients with ARDS group had a higher 60-day mortality rate, an increased demand for invasive mechanical ventilation, and a longer intensive care unit (ICU) stay than those without ARDS ( p < .001 for all). Partial pressure of oxygen (PaO2): fraction of inspired oxygen (FiO2) < 200, platelets <125 × 109/L, lactate dehydrogenase >250 U/L, creatinine >111 mg/dL, and procalcitonin >0.5 ng/mL were independent risk variables for development of ARDS in SAP patients. The area under the curve for the model was 0.814, and the model fit was acceptable [ p = .355 (Hosmer–Lemeshow)]. Incorporating these 5 factors, a nomogram was established with sufficient discriminatory power (C-index 0.814). Calibration curve indicated the proper discrimination and good calibration in the predicting nomogram model. Conclusion: The prediction nomogram for ARDS in patients with SAP can be applied using clinical common variables after the diagnosis of SAP. Future studies would be warranted to verify the potential clinical benefits of this model.

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Section: Discussionsupporting

confidence: 92%

A prediction model for acute respiratory distress syndrome among patients with severe acute pancreatitis: a retrospective analysis

Lin

Han

et al. 2022

Ther Adv Respir Dis

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“…Macrophages promote cell apoptosis through phagocytic cell debris and secretion of cytokines, thereby aggravating the inflammatory response. [15] Our study found that in children with primary short-term relapse of intussusception, the expression of MCP-1 in the peripheral blood was significantly greater than that of non-relapsed children. Some scholars have pointed out that the occurrence of primary intussusception has a clear relationship with some inflammatory mediators, such as IL-6.…”

Section: Discussionmentioning

confidence: 68%

Significance of MCP-1 in predicting the short-term recurrence of primary intussusception in children: An observational study

Zhu¹,

Xu²,

Zhang³

et al. 2022

Medicine

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To evaluate the relationship between the expression level of (MCP-1) in peripheral blood and the short-term recurrence of primary intussusception in children, a retrospective analysis of children with primary intussusception under ultrasound-guided hydrostatic reduction in our hospital from June 2019 to June 2021, a total of 412 cases, 37 cases of short-term recurrence. Enzyme-linked immunosorbent assay was used to detect the expression of MCP-1 in peripheral venous blood; receiver operating curve (ROC) was utilized to evaluate the diagnostic efficacy of MCP-1 in predicting short-term recurrence; logistic regression analysis of risk factors for recurrence. MCP-1 increased in the peripheral blood of children with short-term recurrence (P < .05). Logistic regression analysis found that increased MCP-1 was a risk factor for recurrence; ROC showed that 23.24 ng/mL was used as a cut-off value. The sensitivity of MCP-1 for predicting the recurrence of intussusception in children is 82.14%, and the specificity is 75.67%. In primary intussusception, the expression of MCP-1 in the peripheral blood of children with short-term recurrence is raised. Elevated expression of MCP-1 is a risk factor for predicting short-term intussusception recurrence and has certain clinical significance.

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“…Clinical evidence of respiratory failure may not be obvious in these patients, and only 11% of these patients have radiological evidence of respiratory complications . The radiological changes are in the form of patchy infiltrates on chest radiography and as patchy areas of consolidations and atelectasis on CT …”

Section: Pulmonary Complicationsmentioning

confidence: 99%

“…A greater number of comet tail artifacts are described in patients with respiratory dysfunction, severe disease, and with elevated C‐reactive protein (CRP). It was found to be particularly useful when only ultrasound of the nondependent lung (lower lateral and upper quadrants) was performed …”

Section: Pulmonary Complicationsmentioning

confidence: 99%

Thoracic complications of pancreatitis

2018

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Acute pancreatitis in its severe form may lead to systemic inflammatory response syndrome and multisystem organ dysfunction. Acute lung injury is an important cause of mortality in the setting of severe acute pancreatitis. Besides lung involvement, acute and chronic pancreatitis may also lead to the involvement of other thoracic compartments, including mediastinum, pleura, and vascular structures. These manifestations are an important cause of morbidity and may pose diagnostic and therapeutic challenges. These manifestations have not been discussed in detail in the available literature. In this review, we discuss the thoracic complications of pancreatitis, including lung, pleural, mediastinal, and vascular manifestations.

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Lung ultrasonography as a direct measure of evolving respiratory dysfunction and disease severity in patients with acute pancreatitis

Abstract: Background: The value of lung ultrasonography in the diagnosis of respiratory dysfunction and severity stratification in patients with acute pancreatitis (AP) was investigated.

Cited by 4 publications

References 41 publications

A prediction model for acute respiratory distress syndrome among patients with severe acute pancreatitis: a retrospective analysis

A prediction model for acute respiratory distress syndrome among patients with severe acute pancreatitis: a retrospective analysis

Significance of MCP-1 in predicting the short-term recurrence of primary intussusception in children: An observational study

Thoracic complications of pancreatitis

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