Luteal Function Following the Infusion of Prostaglandin F2α into the Uterine Vein of the Ewe

Chamley, W. A.; Cerini, J.C.; Cerini, Mildred; Cumming, I. A.; Goding, J. R.; O’Shea, J. D.

doi:10.1095/biolreprod11.2.191

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…Regression of the corpus luteum can be induced by the infusion of PGFz, (42,112,128,129). Since PGFz, is a known vasoactive agent, several experiments have tested the hypothesis that it induces luteolysis by reducing the blood flow to the corpus luteum (133).…”

Section: Ovarian Blood Flowmentioning

confidence: 99%

Circulation to Female Reproductive Organs

Meschia

1983

Comprehensive Physiology

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Section: Ovarian Blood Flowmentioning

confidence: 99%

Circulation to Female Reproductive Organs

Meschia

1983

Comprehensive Physiology

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“…The results also suggest that a deficiency of LH on the day of oestrus is not one of the factors limiting the number of eggs shed in flocks like the 'C and ' with genetically low fecundity. Prostaglandin F2a (PGF2lI) has been shown to cause luteolysis in the ewe when infused into the ovarian artery (Chamley & co-authors, 1972) or uterine vein (Chamley, Cerini, Cerini, Cumming, Goding & O'Shea, 1974). Little is known about the mechanisms by which PGF2c[ exerts this effect.…”

Section: Proceedingsmentioning

confidence: 99%

Proceedings of the Australian Society for Reproductive Biology

Bindon¹

1975

Reproduction

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“…During early luteal phase, PGF 2α may act as a luteo-supporting factor (18)(19)(20) and play a luteoprotective role (21)(22)(23). Uterine PGF 2α is necessary to induce luteolysis on days 17-18 of the estrous cycle in cattle, and initiates a new reproductive cycle (1,(24)(25)(26)(27). Additionally, CL regression can be pharmacologically induced by the administration of exogenous PGF 2α in the middle stage of the estrous cycle, when CL is sensitive to PGF 2α (24,28).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Intra-CL Injection and Peripheral Application of Prostaglandin F2α Analog on Luteal Blood Flow and Secretory Function of the Bovine Corpus Luteum

2022

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We investigated the effects of different doses of dinoprost injected directly into the bovine corpus luteum (CL) on (i) concentrations of progesterone (P4) and oxytocin (OT) in peripheral blood and (ii) mRNA levels of steroidogenic acute regulatory protein (STAR), cytochrome P450 family 11 subfamily A member 1 (P450scc), hydroxy-delta-5-steroid dehydrogenase, 3 β- and steroid delta-isomerase 1 (HSD3B), and receptor-interacting protein kinases 1 and 3 (RIPK1, RIPK3) in CL tissue. Moreover, we examined the effects of dinoprost, injected intra-CL or administered intramuscularly (IM), on CL secretory function and on indicators of CL vascular network status: luteal tissue area (LTA), CL blood flow (CLBF), and the CLBF:LTA ratio (Adj. CLBF), in cows at the early and mid-luteal phases. In the Experiment 1, cows (day 10 of the cycle) were allocated to (i) an intra-CL injection of saline (control; n = 3); (ii) an intra-CL injection of dinoprost (1.25 mg; 2.5 mg, or 5 mg; n = 3 for each dose); (iii) an IM administration of saline (control; n = 3); or (iv) an IM administration of dinoprost (25 mg; positive control; n = 3). Concentrations of OT and P4 were measured in plasma samples. The mRNA expression of steroidogenesis- or necroptosis-related factors was determined in CL tissue 4 h after treatments. In Experiment 2, cows on day 4 (n = 12) or day 10 (n = 12) were allocated to (i) an intra-CL injection of dinoprost (2.5 mg/0.5 ml; n = 6), or (ii) IM administration of dinoprost (25 mg/5 ml; n = 6). Concentrations of P4 were measured in plasma samples. Luteal tissue area, CLBF, and Adj. CLBF were assessed based on color Doppler ultrasonography. An intra-CL injection of dinoprost increased OT and decreased P4 levels in the jugular vein (JV) in a dose-dependent manner in cows at the mid-luteal phase. Increased CLBF and Adj. CLBF, accompanied by reduced P4 levels, were observed 2 h after intra-CL dinoprost injection in middle-stage CL. Decreased STAR and increased RIPK1 and RIPK3 mRNA levels confirmed that 2.5 mg dinoprost injected directly into CL is the minimum dose that induces luteolytic cascade. Injection of dinoprost directly into the CL (at a dosage lower than recommended for peripheral application) results in a pattern similar to IM dinoprost administration.

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Luteal Function Following the Infusion of Prostaglandin F2α into the Uterine Vein of the Ewe

Cited by 5 publications

References 12 publications

Circulation to Female Reproductive Organs

Circulation to Female Reproductive Organs

Proceedings of the Australian Society for Reproductive Biology

Comparison of Intra-CL Injection and Peripheral Application of Prostaglandin F2α Analog on Luteal Blood Flow and Secretory Function of the Bovine Corpus Luteum

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