Luteinizing hormone response to controlled-release deslorelin in estradiol benzoate primed ovariectomized gilts

Kraeling, Robert R.; Barb, C. R.; Rampacek, George B.; Thompson, Donald L.; Gibson, John W.; Sullivan, Spencer; Simon, B; Burns, Patrick

doi:10.1016/s0093-691x(00)00307-1

Cited by 15 publications

(4 citation statements)

References 15 publications

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“…A flare in testosterone for the low dose but not the high dose could have arisen because of differences in the amount of Deslorelin in the birds' blood immediately following implantation. In mammals, the level of circulating Deslorelin is higher immediately following implantation than the plateau that occurs days later (Kraeling et al 2000). Similar dynamics could account for why we observed a flare in week 1 after the 1 mg/kg dose of a GnRH agonist followed by no systematic deviation from control levels in the following weeks.…”

Section: Discussionsupporting

confidence: 59%

Effectiveness of the GnRH agonist Deslorelin as a tool to decrease levels of circulating testosterone in zebra finches

Murphy

Wilson

Burton

et al. 2015

General and Comparative Endocrinology

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Songbirds are widely used in studies of the neurobiology underlying learning, memory and performance of the sounds used in vocal communication. Development and activity of neurons in many brain sites implicated in those behaviors are closely related to levels of circulating testosterone. Approaches to understand the effects of testosterone in songbirds are presently limited to testosterone implants, which elevate testosterone levels to supraphysiological values, or castration, which eliminates gonadal production of testosterone. Previous studies in mammals indicate that GnRH agonists may be an effective tool to reduce testosterone within that range of extremes and without invasive surgery. To evaluate the effectiveness of the GnRH agonist Deslorelin as a tool to modulate levels of testosterone in songbirds, we recorded the effects of Deslorelin in adult male zebra finches. We recorded songs, body mass and blood testosterone levels pre-treatment, then we gave each bird a small subcutaneous implant of Deslorelin. We measured blood plasma testosterone levels weekly and recorded song behavior and gross morphology of brain, testes and heart at the end of each experiment. Testosterone levels were reduced at the 5mg/kg dose, and the very slight song changes we observed at that dose were like those reported for castrated zebra finches. As expected, there were no changes in the number of cells in androgen-sensitive brain structures. Suppression of testosterone at the 5mg/kg dose was reversible through implant removal. Thus, Deslorelin is a new tool to transiently suppress testosterone levels without the invasiveness and undesirable aftereffects of surgical castration.

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Section: Discussionsupporting

confidence: 59%

Effectiveness of the GnRH agonist Deslorelin as a tool to decrease levels of circulating testosterone in zebra finches

Murphy

Wilson

Burton

et al. 2015

General and Comparative Endocrinology

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“…It is likely that the labor involved with daily injections of sulpiride would preclude routine application of such a treatment regimen, thus a simpler alternative method of stimulating prolactin secretion is required. Single-injection, depot administration of compounds encased in bioerodible polymers has been described (Kraeling et al, 2000). The objective of the present experiment was to test whether estradiol pretreatment would enhance the prolactin response to a single, 3-g injection of domperidone in bioerodible polymer, which could potentially be used in lieu of daily sulpiride injections in the winter stimulatory regimen.…”

Section: Introductionmentioning

confidence: 99%

Estradiol interactions with dopamine antagonists in mares: Prolactin secretion and reproductive traits

Kelley

Thompson

Storer

et al. 2006

Journal of Equine Veterinary Science

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Robert A. Godke, for their help and support with my thesis research. I am extremely indebted to Mr. Franklin "Randy" Wright for his management of the horses during these experiments. A sincere thanks goes to my colleagues who have greatly helped me throughout my graduate career with great support and understanding. First, thank you William A. Storer for your many hours worked at the farm and much needed, directional advice with these intensive projects. A huge thanks goes to Pamela B. Mitcham for her many hard hours and helpful advice. A very special thanks goes to to John Vidrine for all his help and dedication. Jodi Crowley and Maxon McKean, thank you for your support, and Laura R. Gentry, thank you for the much appreciated help with data analysis and radioimmunoassay techniques. Also, gratitude is extended to all the student workers whose hard work, both in the lab and at the farm, was invaluable. My most sincere appreciation is extended to my grandmother, Louise Wyrick, for her support, love, and encouragement throughout my academic career. I also thank my family and friends for their advice, support, and love. iii TABLE OF CONTENTS

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“…References of studies using deslorelin treatment are also available in farm animals for ovulation induction, ovarian function suppression etc. (Kraeling et al, 2000;Silvestre et al, 2009). Delbecchi and Lacasse (2006) found that such treatment could temporarily suppress the return of ovarian cycles in cows.…”

Section: Discussionmentioning

confidence: 99%

Deslorelin treatment of hyperoestrogenism in neutered ferrets (Mustela putorius furo): a case report

2009

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Hyperoestrogenism causing progressive alopecia in neutered ferrets may be induced by ovarian remnant syndrome (ORS) and nodular hyperplasia of the adrenocortex (hyperadrenocorticism, NHA). The objective of the study was to determine whether a slow-release implant of a gonadotropin releasing hormone (GnRH) analogue, deslorelin, has any value in therapy of hyperoestrogenism of adrenocortical origin (NHA). Three supposed cases of NHA with alopecia and other clinical signs of hyperoestrogenism (n = 2 spayed females in oestrous and n = 1 castrated male) were treated with a subcutaneous implant of 4.7 mg deslorelin acetate. Blood samples were collected, and plasma levels of estradiol (E 2 ) were determined just before, and some weeks after treatment. For realistic monitoring, blood samples for E 2 determination were also taken from intact, healthy (untreated control) females after the beginning of heat (n = 5), or 9-21 days after, with hCG induced ovulation (n = 6), or out of breeding season (n = 3). Before treatment, all three alopecic ferrets showed elevated E 2 concentrations (99.45-139.9 pmol/l) similar to the untreated control females in oestrous (61.6-123.02 pmol/l) (P = 0.229). Some weeks after the deslorelin administration, the hair of these ferrets began to grow again and the elevated E 2 concentrations significantly decreased compared to the pre-treatment values (P = 0.035). E 2 concentrations reached the basal level (12.89-16.08 pmol/l) typical for that of the untreated control females in anoestrus or in luteal phase (12.0-30.58 pmol/l) (P = 0.137). All treated ferrets were examined again 19-21 months after implant insertion (the implant still being present) and all of them had normal hair and were clinically healthy. These observations prove that deslorelin can suppress the E 2 production of NHA, and is therefore a useful tool in the therapy of hormonal alopecia neutered ferrets.

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Luteinizing hormone response to controlled-release deslorelin in estradiol benzoate primed ovariectomized gilts

Cited by 15 publications

References 15 publications

Effectiveness of the GnRH agonist Deslorelin as a tool to decrease levels of circulating testosterone in zebra finches

Effectiveness of the GnRH agonist Deslorelin as a tool to decrease levels of circulating testosterone in zebra finches

Estradiol interactions with dopamine antagonists in mares: Prolactin secretion and reproductive traits

Deslorelin treatment of hyperoestrogenism in neutered ferrets (Mustela putorius furo): a case report

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