Lutheran Blood Group System

doi:10.1002/9780470987018.ch6

Human Blood Groups 2002

DOI: 10.1002/9780470987018.ch6

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Lutheran Blood Group System

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2005

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Review: Lutheran/B-CAM: A Laminin Receptor on Red Blood Cells and in Various Tissues

Kikkawa

Miner

2005

Connective Tissue Research

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The Lutheran blood group glycoprotein (Lu), also known as basal cell adhesion molecule (B-CAM), is a transmembrane receptor with five immunoglobulin-like domains in its extracellular region; it is therefore classified as a member of the immunoglobulin (Ig) gene family. Lu/B-CAM is observed not only on red blood cells, but also on a subset of muscle and epithelial cells in various tissues. Recently, several groups have reported that Lu/B-CAM is a novel receptor for laminin a5. The laminin a5 chain is a component of the laminin-511 (alpha 5 beta 1 gamma 1), -521 (alpha 5 beta 2 gamma 1), and -523 (alpha 5 beta 2 gamma 3) heterotrimers and is expressed throughout the mammalian body. We also have shown that Lu/B-CAM is co-localized with laminin alpha 5 in various tissues. Although the biological role of Lu/B-CAM remains unclear, the specific binding of Lu/B-CAM to laminin alpha 5 suggests that it plays an important role in developmental and physiological processes. It also is necessary to investigate further the interaction between Lu/B-CAM and laminin a5 in pathological processes, including sickle cell disease and cancer.

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Review: Lutheran/B-CAM: A Laminin Receptor on Red Blood Cells and in Various Tissues

Kikkawa

Miner

2005

Connective Tissue Research

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Lutheran Blood Group System

Cited by 1 publication

References 108 publications

Review: Lutheran/B-CAM: A Laminin Receptor on Red Blood Cells and in Various Tissues

Review: Lutheran/B-CAM: A Laminin Receptor on Red Blood Cells and in Various Tissues

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