LuxS /AI-2 in Streptococcus agalactiae reveals a key role in acid tolerance and virulence

Ma, Yuanfang; Liang, Hao; Hao, Ke; Liang, Zhiling; Ma, Jin-Yeul; Liu, Zhenxing; Li, Yugu

doi:10.1016/j.rvsc.2017.07.032

Cited by 35 publications

(32 citation statements)

References 44 publications

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“…These B. subtilis quorum-sensing-related genes were deficient in the eight P. polymyxa strains studied, although another important quorum-sensing regulatory gene, luxS , was observed. luxS is a key regulatory gene in quorum sensing mediated by autoinducer 2 (AI-2) ( Federle, 2009 ; Ma et al, 2017 ), which significantly affects biofilm formation in P. polymyxa (this conclusion was obtained in other study by our group, which has not yet been published). In addition, luxS was also found to be a key regulatory gene involved in quorum sensing in P. polymyxa CR1 ( Eastman et al, 2014a ).…”

Section: Discussionmentioning

confidence: 87%

Complete Genome Sequence of Industrial Biocontrol Strain Paenibacillus polymyxa HY96-2 and Further Analysis of Its Biocontrol Mechanism

Luo

Cheng

et al. 2018

Front. Microbiol.

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Paenibacillus polymyxa (formerly known as Bacillus polymyxa) has been extensively studied for agricultural applications as a plant-growth-promoting rhizobacterium and is also an important biocontrol agent. Our team has developed the P. polymyxa strain HY96-2 from the tomato rhizosphere as the first microbial biopesticide based on P. polymyxa for controlling plant diseases around the world, leading to the commercialization of this microbial biopesticide in China. However, further research is essential for understanding its precise biocontrol mechanisms. In this paper, we report the complete genome sequence of HY96-2 and the results of a comparative genomic analysis between different P. polymyxa strains. The complete genome size of HY96-2 was found to be 5.75 Mb and 5207 coding sequences were predicted. HY96-2 was compared with seven other P. polymyxa strains for which complete genome sequences have been published, using phylogenetic tree, pan-genome, and nucleic acid co-linearity analysis. In addition, the genes and gene clusters involved in biofilm formation, antibiotic synthesis, and systemic resistance inducer production were compared between strain HY96-2 and two other strains, namely, SC2 and E681. The results revealed that all three of the P. polymyxa strains have the ability to control plant diseases via the mechanisms of colonization (biofilm formation), antagonism (antibiotic production), and induced resistance (systemic resistance inducer production). However, the variation of the corresponding genes or gene clusters between the three strains may lead to different antimicrobial spectra and biocontrol efficacies. Two possible pathways of biofilm formation in P. polymyxa were reported for the first time after searching the KEGG database. This study provides a scientific basis for the further optimization of the field applications and quality standards of industrial microbial biopesticides based on HY96-2. It may also serve as a reference for studying the differences in antimicrobial spectra and biocontrol capability between different biocontrol agents.

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Section: Discussionmentioning

confidence: 87%

Complete Genome Sequence of Industrial Biocontrol Strain Paenibacillus polymyxa HY96-2 and Further Analysis of Its Biocontrol Mechanism

Luo

Cheng

et al. 2018

Front. Microbiol.

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“…Anginosus , as well as acid resistance and transcription of many virulence genes in Sc. Agalactiae , are also reported to be controlled by AI‐2‐based QS, making QS inhibition an interesting antibacterial strategy (Ma et al., 2017; Wang et al., 2015; Yadav et al., 2018; Zhang et al., 2019; Zhao, Xue, Shang, Sun, & Sun, 2010). Here, we take V. harveyi as a typical example to explain this AI‐2‐based QS system (Martin‐Rodriguez et al, 2015).…”

Section: Bacterial Toxinsmentioning

confidence: 99%

Antivirulence properties and related mechanisms of spice essential oils: A comprehensive review

Zhang

Gan

Zhang

et al. 2020

Comp Rev Food Sci Food Safe

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In recent decades, reduced antimicrobial effectiveness, increased bacterial infection, and newly emerged microbial resistance have become global public issues, leading to an urgent need to find effective strategies to counteract these problems. Strategies targeting bacterial virulence factors rather than bacterial survival have attracted increasing interest, since the modulation of virulence factors may prevent the development of drug resistance in bacteria. Spices are promising natural sources of antivirulence compounds owing to their wide availability, diverse antivirulence phytochemical constituents, and generally favorable safety profiles. Essential oils are the predominant and most important antivirulence components of spices. This review addresses the recent efforts of using spice essential oils to inhibit main bacterial virulence traits, including the quorum sensing system, biofilm formation, motility, and toxin production, with an intensive discussion of related mechanisms. We hope that this review can provide a better understanding of the antivirulence properties of spice essential oils, which have the potential to be used as antibiotic alternatives by targeting bacterial virulence. K E Y W O R D Sbiofilm, mechanisms, motility, quorum sensing, spice essential oils, toxin 1018

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“…Dependent on the type of signaling and sensor systems, the QS of bacteria can be classified. In Table 1, we summarize the pathways associated with each QS system and its distribution in bacteria [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. (1) Acyl-homoserine lactone (AHL) was the earliest discovered signaling molecule produced by Gram-negative bacteria.…”

Section: Regulatory Mechanisms Of Quorum Sensingmentioning

confidence: 99%

Effects of Natural Products on Bacterial Communication and Network-Quorum Sensing

Yang

Meng

et al. 2020

BioMed Research International

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Quorum sensing (QS) has emerged as a research hotspot in microbiology and medicine. QS is a regulatory cell communication system used by bacterial flora to signal to the external environment. QS influences bacterial growth, proliferation, biofilm formation, virulence factor production, antibiotic synthesis, and environmental adaptation. Through the QS system, natural products can regulate the growth of harmful bacteria and enhance the growth of beneficial bacteria, thereby improving human health. Herein, we review advances in the discovery of natural products that regulate bacterial QS systems.

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LuxS /AI-2 in Streptococcus agalactiae reveals a key role in acid tolerance and virulence

Cited by 35 publications

References 44 publications

Complete Genome Sequence of Industrial Biocontrol Strain Paenibacillus polymyxa HY96-2 and Further Analysis of Its Biocontrol Mechanism

Complete Genome Sequence of Industrial Biocontrol Strain Paenibacillus polymyxa HY96-2 and Further Analysis of Its Biocontrol Mechanism

Antivirulence properties and related mechanisms of spice essential oils: A comprehensive review

Effects of Natural Products on Bacterial Communication and Network-Quorum Sensing

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