Lycium barbarum polysaccharides: Extraction, purification, structural characterisation and evidence about hypoglycaemic and hypolipidaemic effects. A review

Masci, A.; Carradori, Simone; Casadei, Maria Antonietta; Paolicelli, Patrizia; Petralito, Stefania; Ragno, Rino; Cesa, Stefania

doi:10.1016/j.foodchem.2018.01.176

Cited by 239 publications

(137 citation statements)

References 49 publications

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“…The main signals listed on Table 1 are those which characterizes the presence of monosaccharide units described by their anomeric hydrogen signals of the hydrogen glycosyl units, such as doublets at δ 5.18, 4.91, 4.89, 4.77, 4.59, 4.45, and 4.27 and their respective carbon signals at δ 91.7, 91.3, 93.6, 107.9, 102.6, 101.9, and 93.6. Carbinolic hydrogen δ 3.2 to 4.2 and their respective carbon signals between δ 60.0 to 83.0 and the doublet in δ 0.90 are characteristic of rhamnoses methyl 23‐25 . The occurrence of broadened signals in the carbinolic and anomeric hydrogens it characteristic of the presence of polysaccharides, as well as monosaccharide units.…”

Section: Resultsmentioning

confidence: 96%

Polysaccharide‐rich hydrogel formulation combined with photobiomodulation repairs UV‐induced photodamage in mice skin

Neves

Parizotto

Tim

et al. 2020

Wound Repair Regeneration

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Prolonged skin exposure to ultraviolet radiation (UVR) induces premature aging in both the epidermis and the dermis. Chronic exposure to UVR induces the activation of mitogen‐activated protein kinase (MAPK) signaling pathway, activating c‐Jun, c‐Fos expression, and transcription factor of AP‐1 activating protein. AP‐1 activation results in the positive induction of matrix metalloproteinase (MMP) synthesis, which degrade skin collagen fibers. Polysaccharides from the fruit of Lycium barbarum (LBP fraction) have a range of activities and have been demonstrate to repair the photodamage. In different approaches, laser application aims to recover the aged skin without destroying the epidermis, promoting a modulation, called photobiomodulation (PBM), which leads to protein synthesis and cell proliferation, favoring tissue repair. Here we developed a topical hydrogel formulation from a polysaccharide‐rich fraction of Lycium barbarum fruits (LBP). This formulation was associated with PBM (red laser) to evaluate whether the isolated and combined treatments would reduce the UVR‐mediated photodamage in mice skin. Hairless mice were photoaged for 6 weeks and then treated singly or in combination with LBP and PBM. Histological, immunohistochemistry, and immunofluorescence analyses were used to investigate the levels of c‐Fos, c‐Jun, MMP‐1, −2, and −9, collagen I, III, and FGF2. The combined regimen inhibited UVR‐induced skin thickening, decreased the expression of c‐Fos and c‐Jun, as well as MMP‐1, −2, and −9 and concomitantly increased the levels of collagen I, III, and FGF2. The PBM in combination with LBP treatment is a promising strategy for the repair of photodamaged skin, presenting potential clinical application in skin rejuvenation.

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Section: Resultsmentioning

confidence: 96%

Polysaccharide‐rich hydrogel formulation combined with photobiomodulation repairs UV‐induced photodamage in mice skin

Neves

Parizotto

Tim

et al. 2020

Wound Repair Regeneration

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“…Lycium barbarum has long been well-known as a traditional Chinese medicine that promotes health and longevity and is mainly cultivated in the Ningxia district of China (6,7). Studies have shown that Lycium barbarum polysaccharides (LBP) possess multiple pharmacological functions including immunomodulatory, antioxidant, hypolipidemic, anti-tumor, and anti-aging functions (8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Lycium barbarum Polysaccharides Improve Testicular Spermatogenic Function in Streptozotocin-Induced Diabetic Rats

et al. 2020

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The objective of this study was to investigate the protective effects of Lycium barbarum polysaccharides (LBP) on testicular spermatogenic function in streptozotocin (STZ)-induced diabetic rats. Compared to the control group, blood glucose levels were significantly increased and the insulin resistance was markedly aggravated in STZ-induced diabetic rats. Further, the weight of testis and epididymis and the sperm number and motility were decreased in diabetic rats. Pathological changes were also observed in the spermatogenic tubules, along with a decreased number of spermatogenic cells, downregulated proliferating cell nuclear antigen (PCNA) expression, and increased cell apoptosis in the testes. Compared to the saline-treated diabetic rat group, metformin and LBP treatment significantly decreased the level of blood glucose and improved insulin resistance and testicular function. After treatment with metformin and LBP, the pathological changes in the spermatogenic tubules improved significantly, with an increase in the number of spermatogenic cells, upregulation of PCNA, and suppression of apoptosis in the testes. The expressions of sirtuin 1 (SIRT1) and hypoxia-inducible factor 1-alpha (HIF-1α) in diabetic testes were also upregulated by metformin or LBP treatment. In summary, LBP exerted protective effects by increasing cell proliferation, inhibiting cell apoptosis, and regulating SIRT1/HIF-1α expression in the testes of diabetic rats.

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“…with health benefits such as immunity enhancement, antioxidant, anti-aging and anti-tumor effects, Goji berry has been proposed as functional food and included in the category of "superfoods" [4,[7][8][9][10][11][12][13][14][15][16][17]. Other major aspects of the medicinal quality of Goji fruit are heart disease risk reduction, hypoglycaemic, hypolipidemic and neuroprotective effects, prevention of some eye diseases and male fertility facilitation [18][19][20]. However, Goji berry consumption could be associated to risk of allergic reactions [21].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Lycium barbarum L. berry cultivated in North Macedonia: A chemometric approach

Covaci

Șenilă

Leopold

et al. 2020

JBR

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BACKGROUND: Lycium barbarum L. has received considerable attention due to nutritional value of berries and its cultivation in Europe has attracted growing interest. OBJECTIVE: The aim of the study was characterization of Lycium barbarum L. berry cultivated in North Macedonia in terms of nutritional and functional properties and comparison with Lycium chinense M. variety. METHODS: Minerals, total proteins, sugars, antioxidant activity, fatty acids, carotenoids and polyphenols were determined and lipid indices were evaluated. Principal Component Analysis was used to describe variability of composition, while heat map to recognize the parameters significantly different for varieties. RESULTS: Lycium barbarum L. cultivated in North Macedonia represents a rich source of K, Cu, Mn, P, Zn, Mg, Fe and antioxidant compounds. Polyunsaturated fatty acids (mainly linolenic acid) were dominant in oil resulting in very low atherogenic and thrombogenic indices. A variability of 35.1% was ascribed to minerals, carbohydrates and proteins, 22.3% to ω-6 fatty acids and lipid indices of oil, 19.4% to nutrients with antioxidant activity and 13.4% to ω-3 fatty acids (n-3 and n-3/n-6 ratio). CONCLUSIONS: Chemometric analysis highlighted significant differences in terms of inorganic nutrients, antioxidant capacity, proteins, sugar profile and lipid indices in Lycium barbarum L. compared to Lycium chinense M.

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Lycium barbarum polysaccharides: Extraction, purification, structural characterisation and evidence about hypoglycaemic and hypolipidaemic effects. A review

Cited by 239 publications

References 49 publications

Polysaccharide‐rich hydrogel formulation combined with photobiomodulation repairs UV‐induced photodamage in mice skin

Polysaccharide‐rich hydrogel formulation combined with photobiomodulation repairs UV‐induced photodamage in mice skin

Lycium barbarum Polysaccharides Improve Testicular Spermatogenic Function in Streptozotocin-Induced Diabetic Rats

Characterization of Lycium barbarum L. berry cultivated in North Macedonia: A chemometric approach

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