Lycopene and other carotenoid intake in relation to risk of uterine leiomyomata

Abstract

Objective-Carotenoids have antioxidant properties and have been associated with reduced risks of some cancers. We hypothesized that carotenoid intake may reduce the risk of diagnosed uterine leiomyoma (UL).Study design-We evaluated the associations between dietary carotenoids and risk of diagnosed UL in 82,512 premenopausal women ages 26-46 in 1991 in the Nurses' Health Study II over ten years of follow up. Diet was assessed every four years with a validated food frequency questionnaire, and incidence of UL was assessed biennially by questionnaire.Results-Total lycopene intake was not associated with diagnosed UL risk. Intake of beta-carotene were associated with slightly increased risks of diagnosed UL; this association was restricted to current smokers (for highest vs. lowest quintile, RR = 1.36, 95% CI= 1.05-1.76; p trend = 0.003).Conclusions-Overall, our findings do not suggest that carotenoids reduce the risk of diagnosed UL. Among current smokers, high intake of beta-carotene may slightly increase risk of diagnosed UL.

Leiomyoma and Nutrition, a Case-Control Study

“…In a study on the relationship between using Lycopene, Carotene and uterine myoma, done by Catherin Trey et al (2008), it was found that in smokers who used Carotene, the probability of diagnosing uterine myoma is more than other people. that is not in agreement with our study (14).…”

“…Paradoxical results were seen in some studies investigating the effect of nutrition on leiomyoma. In a study done in 2008, there was no relationship between consumption of carotenoid-containing foods and leiomyoma (14). In a similar study in America in 2008, there was found no relationship between the diet in general, high-fiber diet, soya and leiomyoma but in this study, drinking alcohols increased leiomyoma (15).…”

Genetic integrity assessment of cryopreserved tomato(Lycopersicon esculentum Mill.) genotypes

“…In tomato, LCY-B is considered an important carotenogenic gene that codifies a crucial enzyme involved directly in the synthesis of α-carotene and β-carotene through the cyclization of lycopene (Moreno et al, 2013). As the most powerful antioxidant in the carotenoid family, lycopene plays an important role in the prevention of cancer and chronic diseases (Rao and Agarwal, 2000;Terry et al, 2008). Tomato carotenoids are beneficial not only for human health but also for major breeding traits such as fruit color (Gady et al, 2012).…”

Prevalência de diagnóstico médico auto-relatado de miomas uterinos em população brasileira: Padrões demográficos e socioeconômicos no Estudo Pró-Saúde *

“…In these studies, higher frequencies of tumors stood out among black women 4,[23][24][25][26] , those exposed to factors associated with the increase in ovarian hormones (estrogen and progesterone), those undergoing hormonal therapy 27 , those consuming greater amounts of red meat and sausages 28 , those aged between 40 and 50 years 4,29 , those who had had an early menarche [30][31][32] , those with a high BMI 31,[33][34][35][36] and fat percentage 37 , and those with an increase in weight during adulthood 33,34,38 . On the other hand, lower frequencies of tumors were found in women who practiced physical activities 39 , smokers 30,33,40,41 , those with a higher number of children [30][31]36,42 , those who had reached menopause 36 and those who consumed greater amounts of fruits, vegetables and fish 28,35 . Whereas studies conducted in the United States indicate prevalences of up to 80%, depending on the characteristics of the sub-groups studied, European studies have revealed significantly lower prevalences of tumors 43 .…”