Lyme Disease

Huppertz, Hans‐Iko; Dressler, Frank

doi:10.1016/b978-1-4160-6581-4.10038-x

Cited by 3 publications

(3 citation statements)

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“…In the case of newly appearing arthritis, a borrelial serology should be obtained, especially in mono- or oligoarthritis, including the knee joint [ 14 ]. In case of Lyme arthritis, the enzyme immunoassay is highly positive for IgG antibodies against B .…”

Section: Suspicion Of Lyme Arthritismentioning

confidence: 99%

Rational diagnostic strategies for Lyme borreliosis in children and adolescents: recommendations by the Committee for Infectious Diseases and Vaccinations of the German Academy for Pediatrics and Adolescent Health

Huppertz¹,

Bartmann

Heininger

et al. 2012

Eur J Pediatr

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The varying clinical manifestations of Lyme borreliosis, transmitted by Ixodes ricinus and caused by Borrelia burgdorferi, frequently pose diagnostic problems. Diagnostic strategies vary between early and late disease manifestations and usually include serological methods. Erythema migrans is pathognomonic and does not require any further laboratory investigations. In contrast, the diagnosis of neuroborreliosis requires the assessment of serum and cerebrospinal fluid. Lyme arthritis is diagnosed in the presence of newly recognized arthritis and high-titer serum IgG antibodies against B. burgdorferi. The committee concludes the following recommendations: Borrelial serology should only be ordered in case of well-founded clinical suspicion for Lyme borreliosis, i.e., manifestations compatible with the diagnosis. Tests for borrelial genomic sequences in ticks or lymphocyte proliferation assays should not be ordered. When results of such tests or of serological investigations that were not indicated are available, they should not influence therapeutic decisions. Laboratories should be cautious when interpreting results of serological tests and abstain from giving therapeutic recommendations and from proposing retesting after some time without intimate knowledge of patient's history and disease manifestations.

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Section: Suspicion Of Lyme Arthritismentioning

confidence: 99%

Rational diagnostic strategies for Lyme borreliosis in children and adolescents: recommendations by the Committee for Infectious Diseases and Vaccinations of the German Academy for Pediatrics and Adolescent Health

Huppertz¹,

Bartmann

Heininger

et al. 2012

Eur J Pediatr

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show abstract

“…(Steere et al, 1987;Bianchi et al, 1990;Valesova and Trnavsky, 1990;Herzer, 1991;Huppertz and Karch, 1991;Hammers-Berggren et al, 1992;Huppertz et al, 1995b;Gerber et al, 1998;Sigal, 1998a;Steere, 2001;Huppertz and Dressler, 2010;Stanek and Strle, 2003). Myalgia, myositis, and enthesitis are not a common finding, although B. burgdorferi have been found by polymerase chain reaction in rare patients with enthesitis or nodular fasciitis (Reimers et al, 1993;Häupl et al, 1993;Schnarr et al, 2002).…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Subsequently it became clear that this arthritis was caused by the spirochete Borrelia burgdorferi (Burgdorfer et al, 1982, Steere et al, 1983 and that arthritis was one of many possible manifestations of the illness now known as Lyme borreliosis or Lyme disease (Steere, 2001;Stanek and Strle, 2003;Huppertz and Dressler, 2010). In retrospect the oldest published instance was probably the description of several patients with "rheumatism" accompanying lymphocytic meningitis and inflammatory polyneuritis in Germany in 1941 (Bannwarth, 1941).…”

mentioning

confidence: 99%