Lyme disease: A rigorous review of diagnostic criteria and treatment

Borchers, Andrea T.; Keen, Carl L.; Huntley, Arthur C.; Gershwin, M. Eric

doi:10.1016/j.jaut.2014.09.004

Cited by 132 publications

(176 citation statements)

References 574 publications

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“…One could argue that the presence of IgM is significant for an early infection, but it is well known that both IgM and IgG Borrelia-specific antibodies may persist for years in some patients, which makes it impossible to distinguish between past and newly acquired infections based on seropositivity alone (16). Antibodies against Borrelia burgdorferi sensu lato in the IgM class were found in another report in one of two patients with ParryRomberg syndrome (13).…”

Section: Discussionmentioning

confidence: 99%

Parry–Romberg syndrome: a case with a possible association with Lyme disease

Stinco

Kang

et al. 2015

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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Section: Discussionmentioning

confidence: 99%

Parry–Romberg syndrome: a case with a possible association with Lyme disease

Stinco

Kang

et al. 2015

Acta Dermatovenerologica Alpina Pannonica Et Adriatica

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“…1 Related to the bacterial diseases transmitted by ticks are Lyme disease, rickettsioses, and tularemia. [2][3][4][5][6][7] Tiboviruses (tick-borne viruses) cause many symptoms with severe effects that affect the central nervous system, such as meningitis, meningoencephalitis with high sequelae, and hemorrhagic diseases. [8][9][10] Protozoan infections, for example, the babesiosis (Babesia bigemina), may also be transmitted by ticks.…”

Section: Introductionmentioning

confidence: 99%

Silver and Silver Chloride Nanoparticles and their Anti-Tick Activity: a Mini Review

Durán¹,

Souza²

2017

J. Braz. Chem. Soc.

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This overview highlights the importance of characterization of biogenic nanoparticles of silver and silver chloride in order to understand the action on ticks or pathogens transmitted by them. These nanoparticles appear as important active principles in this area. They can act against ticks or against major pathogens transmitted by the bite of ticks such as bacteria, viruses or protozoa with equal or better efficacy of antibiotics, antiviral or antiparasitic agents. Anti-tick activities on Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum, Hyalomma isaaci and Haemaphysalis bispinosa are discussed. Perspectives of these nanoparticles acting on bacteria, viruses and protozoa infections are also discussed.

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“…migrans (EM) rash and flu-like symptoms, including fever, fatigue, and myalgia (9,10). If left untreated, later-stage manifestations, such as arthritis, carditis, or neuroborreliosis, may develop (10), underscoring the necessity for early detection and treatment.…”

mentioning

confidence: 99%

“…If left untreated, later-stage manifestations, such as arthritis, carditis, or neuroborreliosis, may develop (10), underscoring the necessity for early detection and treatment.…”

mentioning

confidence: 99%

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T2 Magnetic Resonance Assay-Based Direct Detection of Three Lyme Disease-Related Borrelia Species in Whole-Blood Samples

et al. 2017

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In early Lyme disease (LD), serologic testing is insensitive and seroreactivity may reflect active or past infection. In this study, we evaluated a novel assay for the direct detection of three species of Borrelia spirochetes in whole blood. The T2 magnetic resonance (T2MR) assay platform was used to amplify Borrelia DNA released from intact spirochetes and to detect amplicon. Analytical sensitivity was determined from blood spiked with known concentrations of spirochetes, and the assay's limit of detection was found to be in the single-cell-per-milliliter range: 5 cells/ml for B. afzelii and 8 cells/ml for Borrelia burgdorferi and Borrelia garinii. Clinical samples (n ϭ 66) from confirmed or suspected early LD patients were also analyzed. B. burgdorferi was detected using T2MR in 2/2 (100%) of blood samples from patients with confirmed early LD, based on the presence of erythema migrans and documentation of seroconversion or a positive real-time blood PCR. T2MR detected B. burgdorferi in blood samples from 17/54 (31%) of patients with probable LD, based on the presence of erythema migrans without documented seroconversion or of documented seroconversion in patients with a compatible clinical syndrome but without erythema migrans. Out of 21 clinical samples tested by real-time PCR, only 1 was positive and 13 were negative with agreement with T2MR. An additional 7 samples that were negative by real-time PCR were positive with T2MR. Therefore, T2MR enables a low limit of detection (LoD) for Borrelia spp. in whole blood samples and is able to detect B. burgdorferi in clinical samples.

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Lyme disease: A rigorous review of diagnostic criteria and treatment

Cited by 132 publications

References 574 publications

Parry–Romberg syndrome: a case with a possible association with Lyme disease

Parry–Romberg syndrome: a case with a possible association with Lyme disease

Silver and Silver Chloride Nanoparticles and their Anti-Tick Activity: a Mini Review

T2 Magnetic Resonance Assay-Based Direct Detection of Three Lyme Disease-Related Borrelia Species in Whole-Blood Samples

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