Lymph node macrophages and reticulum cells in the immune response

Abstract

The morphology and kinetics of macrophages and reticulum cells of rat lymph nodes have been studied in relation to the immune response to a second exposure to antigen. During the first 24 h after stimulation monocyte-like exudate macrophages, including some scattered interdigitating cells (IDC), contain granules similar to those present in epidermal Langerhans cells and lymph-borne veiled cells. In this induction phase these macrophages migrate from the marginal sinus into the paracortex and during the migration they gradually transform into IDC. In the proliferation phase the paracortex is mainly populated by transitional macrophages and there are almost no typical IDC present between the lymphoblasts. In the memory phase the relative number of IDC again rapidly increases. During this period in the paracortex there are often typical IDC which contain partially digested necrotic lymphocytes, thus resembling tingible body macrophages (TBM) of the germinal centre in this respect. It is suggested that the newly arrived macrophages induce the lymphoblast reaction, while mature IDC may have an inhibitory function in the memory phase of the immune response. In this phase the phagocytic potential of IDC is clearly shown.

Antigen presenting cells in the nasal mucosa of patients with allergic rhinitis during allergen provocation

“…The observation of a threefold increase in LC in the first 1/2 h after provocation would suggest that the increase of LC numbers is due to migration from the lamina propria and not to mitotic activity, suggested to occur in the skin [35] apart from migration [36]. Moreover, LC seem to be able to migrate fast, i.e, several millimeters within 30 min [37]. Besides migration.…”

The organization of cell populations within lymph nodes: their origin, life history and functional relationships

“…It has been proposed that IDC should be included in the mononuclear phagocyte system because of cells that appear to be transitional in appearance between them and macrophages (Veerman 1974, Kamperdijk et al 1978, Hendriks 1981. While there is no doubt about the bone-marrow origin of IDC (Barclay 1981b), the ineptitude of .IDC in phagocytosing tracer particles in vitro seems unworthy of real macrophages.…”

Angiosarcoma with Tingible Body Macrophages

“…5 However, more recent evidence has demonstrated that germinal centers can form in the absence of tingible body macrophages, which counters this hypothesis. 5 In hematopathology, tingible body macrophages can serve as a diagnostic clue when evaluating lymphoid proliferations. When tingible body macrophages are seen in conjunction with other features of reactive follicles (polarization, normal encompassing mantle zone, absence of bcl-2 positivity, and high Ki-67 index), the diagnosis of a reactive process is favored.…”

“…In addition to functioning as lymphoid follicle scavengers, tingible body macrophages have been shown to interact with B‐lymphocytes and follicular dendritic cells in germinal centers and exhibit a prostaglandin‐mediated regulatory role 3–4 . It has also been hypothesized that tingible body macrophages may play an integral role in initiating germinal center formation 5 . However, more recent evidence has demonstrated that germinal centers can form in the absence of tingible body macrophages, which counters this hypothesis 5 …”

“…It has also been hypothesized that tingible body macrophages may play an integral role in initiating germinal center formation 5 . However, more recent evidence has demonstrated that germinal centers can form in the absence of tingible body macrophages, which counters this hypothesis 5 …”