Lymph node metastasis in nasal vestibule cancer: A review

Abstract

SCCNV is an uncommon form of cancer, possibly originating in the mucocutaneous junction. The incidence of lymph node metastasis is variably reported. The data in the literature do not provide a solid basis for recommendations on elective treatment of the neck. Thorough examination of the neck is recommended, preferably with modern imaging techniques.

Comparison of interstitial brachytherapy and surgery as primary treatments for nasal vestibule carcinomas

“…Whilst neck metastasis is a proven negative prognostic factor, contradicting results are reported concerning the prognostic significance of the primary subsite of origin, as some authors report a worse survival for primary septal SCC, whereas others do not find any correlation . In our small series with primary tumors arising from all the subsites of the NV, such correlation is not evident either.…”

“…We had two nodal recurrences (one in the BRT and the other in the surgical group) in non–primarily dissected cases (20%), both cT2 according to Wang; one was successfully salvaged (pN1), and the other died. Therefore, the indications for a prophylactic treatment of the neck (surgical or radiotherapeutic), especially in cT2 cases, and whether an extensive use of modern morphologic and functional imaging before treatment planning could reduce the rate of false cN0 cases and of nodal recurrences, deserve to be further evaluated on larger series with longer follow‐up …”

Irradiation of localized squamous cell carcinoma of the nasal vestibule

“…In the literature, the incidence of nodal metastasis at diagnosis is approximately 5% . Without elective nodal treatment, approximately 15% of patients develop nodal relapse . Advanced tumor stage indicates a higher incidence of nodal involvement, with a rate as high as around 40% in larger primary tumors .…”

“…9,17 Without elective nodal treatment, approximately 15% of patients develop nodal relapse. 18 Advanced tumor stage indicates a higher incidence of nodal involvement, with a rate as high as around 40% in larger primary tumors. 18 In this series, there was a high regional failure rate in T2 tumors (23%), as in other head and neck malignancies elective neck irradiation could be considered.…”

“…18 Advanced tumor stage indicates a higher incidence of nodal involvement, with a rate as high as around 40% in larger primary tumors. 18 In this series, there was a high regional failure rate in T2 tumors (23%), as in other head and neck malignancies elective neck irradiation could be considered. Metastatic spread of SCC of the nasal vestibule is usually to the ipsilateral submandibular (level IB) and nasolabial (buccinator and mandibular) nodes.…”