Lymph node metastasis of ovarian cancer: A preliminary survey of 74 cases of lymphadenectomy

Wu, Pao-Chen; Qu, Jing-Yi; Lang, Jinghe; Huang, Rui; Tang, Min-Yi; Lian, L

doi:10.1016/0002-9378(86)90359-5

Cited by 91 publications

(19 citation statements)

References 4 publications

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“…Several autopsy studies have demonstrated that lymph node metastases are a frequent event in women who die of ovarian cancer and have shown that abdominopelvic lymph nodes, as well as supradiaphragmatic and inguinal lymph nodes, may be involved. 15,19,26 However, these studies did not state whether the women had lymph node metastases at presentation. Recent studies have demonstrated that more than 50% of women with ovarian or peritoneal carcinoma may have retroperitoneal lymph node involvement at the time of initial staging with the risk of nodal metastases increasing as the stage of disease advances.…”

Section: Discussionmentioning

confidence: 94%

“…In these patients, the lymphadenopathy is frequently associated with widely disseminated intra-abdominal disease and is usually discovered at the time of staging laparotomy. 1,25,26 Palpable extra-abdominal lymphadenopathy at the time of presentation is distinctly uncommon. Even less common are patients who present with extra-abdominal serous carcinoma and have minimal intra-abdominal peritoneal disease.…”

mentioning

confidence: 97%

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Serous Carcinoma of the Ovary, Fallopian Tube, or Peritoneum Presenting as Lymphadenopathy

Euscher¹,

Silva²,

Deavers³

et al. 2004

American Journal of Surgical Pathology

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The clinicopathologic features of 35 cases of serous carcinoma of the ovary, fallopian tube, or peritoneum presenting as lymphadenopathy are described. The cases were retrieved from the files of the Department of Pathology at the University of Texas M. D. Anderson Cancer Center from a 20-year period (1982-2002). The following parameters were evaluated: patient age at diagnosis, lymph node involved, primary tumor site, tumor histology, peritoneal disease status, and survival. The patients ranged in age from 30 to 85 years (mean, 59 years). The lymph nodes involved were inguinal, 20 cases; supraclavicular, 11 cases; axillary, 2 cases; cervical, 1 case; and retroperitoneal, 1 case. Primary tumor sites included 20 ovarian, 10 peritoneal, and 2 fallopian tube. In 2 patients, total abdominal hysterectomy/bilateral salpingo-oophorectomy and complete staging showed no additional tumor, and in 1 patient with a previous history of total abdominal hysterectomy/bilateral salpingo-oophorectomy for a benign condition, imaging studies did not identify a primary site. The carcinoma was high grade in 30 cases and low grade in 4 cases. In one case, the diagnosis was made on cytology material and the tumor could not be graded. Peritoneal disease status was known in 33 patients and was as follows: omentum with gross disease, 16 cases; and omentum without gross disease, 17 cases. Follow-up was available in 33 patients and ranged from 4 to 204 months, with a median survival of 36 months for stage III patients and 29 months for stage IV patients. Patients with adenopathy and minimal peritoneal disease (grossly negative omentum) had a median survival of 120 months compared with 24 months for those with bulky peritoneal disease (grossly positive omentum). Serous carcinoma of the ovary, fallopian tube, or peritoneum presenting as a lymph node metastasis is uncommon. In rare cases, a primary site may not be found. The median survival of the patients for stage is not appreciably different from those patients presenting in the usual fashion, suggesting that this atypical presentation does not adversely affect survival. Patients with minimal peritoneal disease and extra-abdominal lymph node metastases survive longer than those with bulky peritoneal disease

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Section: Discussionmentioning

confidence: 94%

mentioning

confidence: 97%

Serous Carcinoma of the Ovary, Fallopian Tube, or Peritoneum Presenting as Lymphadenopathy

Euscher¹,

Silva²,

Deavers³

et al. 2004

American Journal of Surgical Pathology

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“…Involvement of pelvic and inguinal lymph nodes occurs in late stages of the disease resulting from the retrograde flow of tumor cells to these lymphatic channels. 3,4 The round ligament is a direct route of lymphatic spread to the pelvic and inguinal lymph nodes as well. Nonetheless, inguinal lymph node metastasis is rare in advanced 1 reported inguinal lymph node involvement in only 3% of these patients.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Inguinal Lymphadenopathy, Presenting as the Only Physical Evidence of Recurrent Ovarian Carcinoma

Mahdavi¹,

Malviya²,

Husain³

2003

Journal of Gynecologic Surgery

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Inguinal lymph node metastasis is a rare site of involvement in recurrent epithelial ovarian cancer. We discuss five patients with recurrent epithelial ovarian cancer who presented with enlarged inguinal lymph nodes as the only physical evidence of disease recurrence. Four patients had involvement of the pelvic lymph nodes that were ipsilateral to the involved inguinal nodes. Inguinal-femoral lymphadenectomy significantly decreased the bulk of tumors in these patients. Involvement of the pelvic lymph nodes is a risk factor for recurrence of epithelial ovarian cancer in the ipsilateral inguinal lymph nodes. Surgical excision of the inguinal node metastasis may play a role in improving the survival of these patients. (J GY-NECOL SURG 19:81)

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“…Dans notre étude, la fréquence de l'envahissement ganglionnaire en cas de curage d'emblée ou après chimiothéra-pie est comparable à celle décrite par d'autres auteurs (Tableau 4) [9][10][11][12][13][14][15]. Comme d'autres l'ont déjà observé, la fréquence de l'atteinte ganglionnaire, notamment en cas de stade précoce (stade I ou II), est comparable avant et après la chimiothérapie (Tableau 2).…”

Section: Discussionunclassified

Les métastases ganglionnaires du cancer épithélial de l'ovaire sont-elles chimio-sensibles ? Étude comparative de la lymphadénectomie première ou après chimiothérapie

Joulie

Morice

Rey

et al. 2004

Gynécologie Obstétrique & Fertilité

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Lymph node metastasis of ovarian cancer: A preliminary survey of 74 cases of lymphadenectomy

Cited by 91 publications

References 4 publications

Serous Carcinoma of the Ovary, Fallopian Tube, or Peritoneum Presenting as Lymphadenopathy

Serous Carcinoma of the Ovary, Fallopian Tube, or Peritoneum Presenting as Lymphadenopathy

Metastatic Inguinal Lymphadenopathy, Presenting as the Only Physical Evidence of Recurrent Ovarian Carcinoma

Les métastases ganglionnaires du cancer épithélial de l'ovaire sont-elles chimio-sensibles ? Étude comparative de la lymphadénectomie première ou après chimiothérapie

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