Lymph nodes tuberculosis: a retrospective study on clinical and therapeutic features

Benjelloun, A.; Darouassi, Youssef; Zakaria, Y.; Bouchentouf, R.; Errami, N.

doi:10.11604/pamj.2015.20.65.5782

Cited by 17 publications

(21 citation statements)

References 7 publications

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“…FNA and Mantoux test were able to diagnose 90% of the cases (Anmari et al, 2003;Raviglione et al, 2015); (2) Surgical Excision Biopsy, is preferred over incisional biopsy, the latter may be associated with sinus tract formation. Surgical biopsy-excision of the lymph node is the best examination for diagnostic confirmation with sensitivity of 100% for histological analysis and 60-90% for the bacilli culture (Fontanilla et al, 2011;Banjelloun A., et al, 2015); (3) Bacteriologic confirmation is achieved in the vast majority of cases, granulomatous lesion or without visible AFBs are typically seen, and cultures are positive in 70-80% of cases. However, the negative culture does not necessarily exclude the diagnosis because not all enlarged lymph nodes necessarily contain live bacilli.…”

Section: Discussionmentioning

confidence: 99%

Tuberculous Lymphadenitis coexists with Non-Hodgkin Lymphoma

Siagian

Bramantono

Hadi

2020

CIMRJ

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Tuberculous Lymphadenitis (TBLN) is most common extrapulmonary tuberculosis. The common symptom of TBLN is cervical lymphadenopathy which is known to mimic numerous pathological conditions like NHL. Coexistency TBLN and lymphoma is a rare. A woman, 56 years old, had chief complaint of cervical masses since 2 months ago. She had history of weight loss, fever and night sweats but no history of chronic cough. From physical examination and supporting examination, the patient was diagnosed with TBLN coexists with NHL. She got antituberculosis drug (ATD) for 2 weeks before chemotherapy. The patient died of septic shock 9 days later after chemotherapy. From HPE examination, TBLN and NHL may show simillar feature so Zhiel-Neelsen staining and Immunohistochemical are important to confirm each disease. ATD was given to supress the mycobacterium activity before chemotherapy. However the patient had febrile neutropenia after chemotherapy and died of septic shock. Both TBLN and NHL may occur with simillar sign and symptom and HPE. Further examinations have to be done to confirm the diagnosis of both disesases. Although ATD had given to prevent Tb infection progresivity. On 7 days after chemotherapy she had febrile neutropenia and lead to death due to septic shock.

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Section: Discussionmentioning

confidence: 99%

Tuberculous Lymphadenitis coexists with Non-Hodgkin Lymphoma

Siagian

Bramantono

Hadi

2020

CIMRJ

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“…The average incidence of new cases worldwide is 26,000 and the global treatment success rate of 83%, similar to recent years. Globally, the incidence of tuberculosis is falling at about 2% per year [1].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Microwave-Heated Ziehl-Neelsen Stain and Conventional Ziehl-Neelsen Method in the Detection of Acid-Fast Bacilli in Lymph Node Biopsies

Ahmed¹,

Mohammed²,

Taha³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Tuberculosis is a chronic inflammatory disease with lymphadenopathy being the most common extra-pulmonary manifestation. The conventional Ziehl–Neelsen method plays an essential role in the diagnosis of tuberculosis; however, it has a low sensitivity in detecting acid-fast bacilli. AIM: The present study emphasises the role of the microwave-heated method (modified Ziehl–Neelsen) over conventional Ziehl-Neelsen stain and to set at the best condition for irradiation. MATERIAL AND METHODS: The study included 90 patients with clinically suspected tuberculous lymphadenopathy who were referred to the Department of Pathology at Omdurman Military Hospital, Sudan. Demographic data such as age, sex, and site of swelling were documented for each patient. Specimens were stained with conventional Ziehl-Neelsen, fluoresce and the modified methods. RESULTS: Patient’s age ranged from 20 to 70 year. Of the total 90 cases with clinically suspected tuberculous lymphadenopathy, 18 cases were positive for AFB in conventional Ziehl-Neelsen method giving a sensitivity of 13.3%, while in microwave-heated method 82 cases of TB were detected positive for AFB yielded sensitivity and specificity of 97.6% and 85.7%, respectively, and positive and negative predictive values of 98.8% and 75.0% respectively compared to fluorescence methods. CONCLUSION: In the present study, the microwave-heated Ziehl-Neelsen method, was found to have sensitivity and specificity of 97.6% and 85.7%, respectively which matches the fluorescence technique. It has specificity in detecting lymph node tuberculosis that makes it superior over all other modified methods. However, the availability and cost-effectiveness might limit the use of fluorescence in routine practice. Furthermore, the study set the best staining temperature is provided at power 1 level (60 w) for 1.5 minutes.

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“…Extrapulmonary tuberculosis accounts for 15-30% of the total cases with tuberculosis, and the lymph node affliction is one of the most frequent 1 . From all peripheral lymph nodes, 70-90% are at the neck level and rarely in the inguinal, axillary, epitrochlear areas 2 .…”

Section: Introductionmentioning

confidence: 99%

“…At the neck level, the most affected nodules are jugular, submandibular, spinal, or at the parotid level. Actually, lymph node tuberculosis can be encountered in any neck region and it is bilateral in 20% of the cases 1,2 . The search for an active pulmonary lesion is positive in immunocompromised patients 3 .…”

Section: Introductionmentioning

confidence: 99%

Lymph node tuberculosis – The ENT surgeon approach in four cases

Vrînceanu

Dumitru

Sajin

et al. 2018

Romanian Journal of Rhinology

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BACKGROUND. Lymph node tuberculosis is a pathology with an increasing incidence and prevalence in middle income countries. MATERIAL AND METHODS. We present a series of 4 cases with cervical lymph node tuberculosis. We review current principles of diagnosis and treatment from the perspective of the ENT surgeon in a tertiary university clinic. RESULTS. In each case we underline diagnosis difficulties and treatment options. These cases presented management difficulties due to associated morbidities. All cases underwent surgical excision of the afflicted lymph nodes with subsequent microscopic confirmation of tuberculosis. We illustrate key concepts leading to the microscopy diagnosis of lymph node tuberculosis. CONCLUSION. There are various surgical incidents and accidents that the young surgeon must be aware of when approaching neck tuberculous lymph nodes. Further referral of the patient for long-term tuberculosis treatment is mandatory. All patients were supervised for a minimum of 1 year after the initial diagnosis and treatment with no sign of recurrence. A close cooperation between the ENT surgeon, the infectious disease specialist and the pathologist is the key to an optimum approach to lymph node tuberculosis at the head and neck level.

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Lymph nodes tuberculosis: a retrospective study on clinical and therapeutic features

Cited by 17 publications

References 7 publications

Tuberculous Lymphadenitis coexists with Non-Hodgkin Lymphoma

Tuberculous Lymphadenitis coexists with Non-Hodgkin Lymphoma

Comparison of the Microwave-Heated Ziehl-Neelsen Stain and Conventional Ziehl-Neelsen Method in the Detection of Acid-Fast Bacilli in Lymph Node Biopsies

Lymph node tuberculosis – The ENT surgeon approach in four cases

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