Lymphangiosarcoma Following Mastectomy

Stewart, Nathaniel J.; Pritchard, Douglas J.; Nascimento, Antonio G.; Kang, Yong-Koo

doi:10.1097/00003086-199511000-00023

Cited by 24 publications

(19 citation statements)

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“…Exposure to radiation is not the only cause of secondary angiosarcoma, however, as is illustrated in the case of Stewart-Treves syndrome. Stewart-Treves syndrome is characterized by angiosarcoma that arises in regions of chronic lymphedema, especially in the breast after breastconserving therapy, regardless of radiation exposure (9,10).…”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma of the Breast

Lim¹,

Goei²

2007

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Section: Discussionmentioning

confidence: 99%

Angiosarcoma of the Breast

Lim¹,

Goei²

2007

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“…. a solitary tumor followed by similar satellite areas that sometimes become confluent, forming a larger lesion" [5]. The tumors often appear as bluish-black, pink nodules on the edematous extremity, which tend to ulcerate and bleed.…”

Section: Discussionmentioning

confidence: 99%

Stewart-Treves syndrome: MR imaging of a postmastectomy upper-limb chronic lymphedema with angiosarcoma

et al. 2004

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The rare occurrence of angiosarcoma in postmastectomy upper-limb lymphedema with magnetic resonance (MR) imaging is discussed. Unfamiliarity with this aggressive vascular tumor and its harmless appearance often leads to delayed diagnosis. Angiosarcoma complicating chronic lymphedema may be low in signal intensity on T2-weighting and short tau inversion recovery (STIR) imaging reflecting the densely cellular, fibrous stroma, and sparsely vascularized tumor histology. Additional administration of intravenous contrast medium revealed significant enhancement of the tumorous lesions. Awareness of angiosarcoma and its MR imaging appearance in patients with chronic lymphedema may be a key to early diagnosis or allow at least inclusion in the differential diagnosis.

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“…3,4 Other factors with an adverse impact on prognosis are older age, tumor necrosis, and epitheloid features. 5 Tumors can arise either de novo (primary AS, pAS) or as secondary conditions in patients with long standing lymphedema 6,7 or after irradiation 8 (secondary AS; sAS), especially in female patients irradiated for breast cancer. In fact, sAS of the breast is by far the most frequent radiation-induced sarcoma in women treated with radiation therapy as part of their initial treatment, 9 with a more than 1000-fold increased relative risk 10 as compared with the general population.…”

mentioning

confidence: 99%