Lymphatic Obstruction in the Pathogenesis of Intestinal Mucosal Atrophy

Fish, Jay C.; McNeel, Linea; Holaday, William J.

doi:10.1097/00000658-196903000-00005

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…An association between inflammatory bowel disease (IBD) and MVT was seen in 1.1% of IBD cases and may contribute to injury through lymphatic derangement. Fibrosis and obstruction of lymphatic vessels produced by tuberculosis, appendicitis/peritonitis, [191] or experimental obstruction of lymphatic vessels [192] can also lead to protein-losing enteropathies which resemble congenital protein-losing syndromes.…”

Section: Lymphatic Gi Pathophysiologymentioning

confidence: 99%

Gastrointestinal lymphatics in health and disease

et al. 2010

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Lymphatics perform essential transport and immune cell regulatory functions to maintain homeostasis in the gastrointestinal (GI) system. Although blood and lymphatic vessels function as parallel and integrated systems, our understanding of lymphatic structure, regulation and functioning lags far behind that of the blood vascular system. This chapter reviews lymphatic flow, differences in lymphangiogenic and hemangiogenic factors, lymphatic fate determinants and structural features, and examines how altered molecular signaling influences lymphatic function in organs of the GI system. Innate errors in lymphatic development frequently disturb GI functioning and physiology. Expansion of lymphatics, a prominent feature of GI inflammation, may also play an important role in tissue restitution following injury. Destruction or dysregulation of lymphatics, following injury, surgery or chronic inflammation also appears to exacerbate GI disease activity and morbidity. Understanding the physiological roles played by GI lymphatics is essential to elucidating their underlying contributions to forms of congenital and acquired forms of GI pathology, and will provide novel approaches for treatment of these conditions.

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Section: Lymphatic Gi Pathophysiologymentioning

confidence: 99%

Gastrointestinal lymphatics in health and disease

et al. 2010

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“…Para a observação dos vasos linfáticos optou-se pela técnica da injeção de azul de metileno no linfonodo mesentérico, que permite uma observação transoperatória do ducto torácico, ao contrário da cateterização linfática, uma técnica mais invasiva ou da linfangiografia que requer radiografia transoperatória [3,4]. A técnica utilizada foi capaz de diagnosticar uma obstrução no fluxo linfático, que foi confirmada durante o exame de necropsia.…”

Section: Discussionunclassified

Linfangiectasia intestinal associada à linfangite lipogranulomatosa em cão da raça Pit Bull

Beheregaray

Gianotti

Lamberts

et al. 2018

Acta Scientiae. Vet.

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RESUMOA linfangiectasia é uma enteropatia desperdiçadora de proteínas, que ocorre devido à drenagem ineficaz da rede linfática, podendo estar acompanhada por uma linfangite lipogranulomatosa, que é a reação ao material de vasos linfáticos que se romperam. Através dos sinais clínicos, que incluem diarréia crônica, efusões cavitárias, edema de membros e emagrecimento progressivo, em conjunto com achados histopatológicos, se obtém o diagnóstico. Este estudo tem como objetivo descrever os aspectos clínicos e patológicos de um caso de linfangiectasia intestinal associada à linfangite lipogranulomatosa em um cão macho, 14 meses de idade, da raça pit bull, que foi atendido no Hospital de Clínicas Veterinárias da Universidade Federal do Rio Grande do Sul. O animal apresentava aumento abdominal, dispnéia, anorexia e cansaço. Em punção abdominal e torácica, observou-se um líquido esbranquiçado classificado, após análise, como quilo. Optou-se, então, pela laparotomia exploratória para identificação de possíveis causas para a alteração, mostrando obstrução do linfonodo mesentérico e pequenos nódulos brancos e irregulares na serosa do intestino delgado. Foi instituído o tratamento com dieta hipocalórica; porém, o paciente acabou indo a óbito decorridas três semanas de tratamento. Aliando-se os sinais clínicos aos exames laboratoriais e achados de necropsia, chegou-se ao diagnóstico definitivo: linfangiectasia intestinal associada à linfangite lipogranulomatosa.Descritores: doença intestinal crônica, enteropatia, linfangiectasia, linfangite lipogranulomatosa, cão. ABSTRACTThe lymphangiectasia is a protein-losing enteropathy coming from a fainling of lynphatics vessels flow. Lipogranulomatous lymphangitis could occour together with lymphangiectasia after reactions by substances witch are present in lynphatics vessels. Clinical signs include chronic diarrhea, peritoneal and pleural effusion, edema of the limbs and progressive weight loss. The final diagnoses were based on clinical signs together with histological findings. The aim of this paper is to describe clinical and pathlogical findings in a case of intestinal lymphangiectasia associated with lipogranulomatous lymphangitis in a male, 14-months-old, pit bull bread dog was referred at Hospital de Clínicas Veterinárias on Universidade Federal do Rio Grande do Sul. The dog was presented with distended abdomen, dyspnea, anorexia and lethargy. At abdominal and thoracic punction were revealed a white fluid classified, after analyse, like chylo. At exploratory surgery a mesenteric lymphonode obstruction was seen and multiple small white lesions occurring along lymphatic vessels on the serosal surface of the small intestine. The treatment was done with low calorie diet. Three weeks later, the patient had died. The necropsy, clinical sings and case evolution, lead to intestinal lymphangiectasia with lipogranulomatous lymphangitis diagnosis.

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“…In the intestine and the pancreas, the myeloperoxidase activity, a marker of neutrophils infiltration, was increased without any change of serum amylase and diamine oxidase level. In another study, lymphatic obstruction in dogs caused an intestinal mucosal atrophy similar to malabsorption syndrome [14]. …”

Section: Discussionmentioning

confidence: 99%

Acute pancreatitis after thoracic duct ligation for iatrogenic chylothorax. A case report

et al. 2017

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BackgroundTo report the association between thoracic duct ligation and acute pancreatitis. The association between sudden stop of lymphatic flow and pancreatitis has been established in experimental models.Case presentation A 57-year-old woman operated for thymoma presented a iatrogenic chylothorax. After thoracic duct ligation, she presented an acute pancreatitis which resolved after conservative treatment. The chylothorax disappeared within 4 days of thoracic duct ligation.ConclusionsThis is the first report of acute pancreatitis following thoracic duct ligation. The pancreas and digestive tract should be assessed in symptomatic patients after thoracic duct ligation.Electronic supplementary materialThe online version of this article (doi:10.1186/s12893-017-0204-3) contains supplementary material, which is available to authorized users.

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Lymphatic Obstruction in the Pathogenesis of Intestinal Mucosal Atrophy

Cited by 6 publications

References 7 publications

Gastrointestinal lymphatics in health and disease

Gastrointestinal lymphatics in health and disease

Linfangiectasia intestinal associada à linfangite lipogranulomatosa em cão da raça Pit Bull

Acute pancreatitis after thoracic duct ligation for iatrogenic chylothorax. A case report

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