Lymphatic Senescence: Current Updates and Perspectives

Filelfi, Sebastian Lucio; Onorato, Alberto; Brix, Bianca; Goswami, Nandu

doi:10.3390/biology10040293

Cited by 10 publications

(9 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Image Analysismentioning

confidence: 99%

“…The aging process induces changes in structure and function of systemic lymphatic networks 60,[62][63][64] . Muscle cell atrophy, elastic element destruction, and aneurysm-like formations have been identified within aged systemic lymphatic vessels 60,[62][63][64] . Animal studies have documented a severe decrease in pump action of these vessels with age, mainly due to decreased contractile speed 62,63 , and likely secondary to age-related enlargement of the lymphatic vessels 63 .…”

Section: Image Analysismentioning

confidence: 99%

“…Muscle cell atrophy, elastic element destruction, and aneurysm-like formations have been identified within aged systemic lymphatic vessels 60,[62][63][64] . Animal studies have documented a severe decrease in pump action of these vessels with age, mainly due to decreased contractile speed 62,63 , and likely secondary to age-related enlargement of the lymphatic vessels 63 . We expect similar changes in the intracranial lymphatic systems with aging.…”

Section: Image Analysismentioning

confidence: 99%

See 2 more Smart Citations

Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes

et al. 2022

View full text Add to dashboard Cite

Meningeal lymphatic vessels have been described in animal studies, but limited comparable data is available in human studies. Here we show dural lymphatic structures along the dural venous sinuses in dorsal regions and along cranial nerves in the ventral regions in the human brain. 3D T2-Fluid Attenuated Inversion Recovery magnetic resonance imaging relies on internal signals of protein rich lymphatic fluid rather than contrast media and is used in the present study to visualize the major human dural lymphatic structures. Moreover we detect direct connections between lymphatic fluid channels along the cranial nerves and vascular structures and the cervical lymph nodes. We also identify age-related cervical lymph node atrophy and thickening of lymphatics channels in both dorsal and ventral regions, findings which reflect the reduced lymphatic output of the aged brain.

show abstract

Section: Image Analysismentioning

confidence: 99%

Section: Image Analysismentioning

confidence: 99%

Section: Image Analysismentioning

confidence: 99%

See 1 more Smart Citation

Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Histological evaluation of the structure of mesenteric lymph nodes in the elderly has revealed general fibrosis, thickening of the capsule and trabeculae, and increased amounts of connective tissue around the blood vessels [36]. The parenchyma of the nodes is typical of involuting lymphoid tissue [43][44][45][46][47][48]. Dense bundles of collagen fibers have been observed in the marginal sinuses of aging lymph nodes, and the sinuses are made of coarse-grained, fragmented fibers and fibroblasts.…”

Section: Stromal Cellsmentioning

confidence: 99%

Aging-Related Cellular, Structural and Functional Changes in the Lymph Nodes: A Significant Component of Immunosenescence? An Overview

Cąkała-Jakimowicz

Kolodziej-Wojnar

Puzianowska-Kuźnicka

2021

Cells

View full text Add to dashboard Cite

Aging affects all tissues and organs. Aging of the immune system results in the severe disruption of its functions, leading to an increased susceptibility to infections, an increase in autoimmune disorders and cancer incidence, and a decreased response to vaccines. Lymph nodes are precisely organized structures of the peripheral lymphoid organs and are the key sites coordinating innate and long-term adaptive immune responses to external antigens and vaccines. They are also involved in immune tolerance. The aging of lymph nodes results in decreased cell transport to and within the nodes, a disturbance in the structure and organization of nodal zones, incorrect location of individual immune cell types and impaired intercellular interactions, as well as changes in the production of adequate amounts of chemokines and cytokines necessary for immune cell proliferation, survival and function, impaired naïve T- and B-cell homeostasis, and a diminished long-term humoral response. Understanding the causes of these stromal and lymphoid microenvironment changes in the lymph nodes that cause the aging-related dysfunction of the immune system can help to improve long-term immune responses and the effectiveness of vaccines in the elderly.

show abstract

“…As a result, any malfunction in this system might result in fluid accumulation within the tissue [10]. A chronic and progressive disease, known as lymphedema, may develop [10,11]. Characteristic for this disease are severe tissue swellings, usually occurring in the upper or lower extremities due to a stasis in lymph flow.…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic Responses in Lower Limb Lymphedema Patients Undergoing Physical Therapy

Brix

White

Ure³

et al. 2021

Biology

Self Cite

View full text Add to dashboard Cite

Background: Lymphedema arises due to a malfunction of the lymphatic system, leading to extensive tissue swelling. Complete decongestive therapy (CDT), which is a physical therapy lasting for 3 weeks and includes manual lymphatic drainages (MLD), leads to fluid mobilization and increases in plasma volume. Here, we investigated hemodynamic responses induced by these fluid shifts due to CDT and MLD. Methods: Hemodynamic parameters were assessed continuously during a sit-to-stand test (5 min baseline, 5 min of standing, and 5 min of recovery). This intervention was repeated on days 1, 2, 7, 14, and 21 of CDT, before and after MLD. Volume regulatory hormones were assessed in plasma samples. Results: A total number of 13 patients took part in this investigation. Resting diastolic blood pressure significantly decreased over three weeks of CDT (p = 0.048). No changes in baseline values were shown due to MLD. However, MLD led to a significant decrease in heart rate during orthostatic loading over all epochs on therapy day 14, as well as day 21. Volume regulatory hormones did not show changes over lymphedema therapy. Conclusion: We did not observe any signs of orthostatic hypotension at rest, as well as during to CDT, indicating that lymphedema patients do not display an elevated risk of orthostatic intolerance. Although baseline hemodynamics were not affected, MLD has shown to have potential beneficial effects on hemodynamic responses to a sit-to-stand test in patients undergoing lymphedema therapy.

show abstract

Lymphatic Senescence: Current Updates and Perspectives

Cited by 10 publications

References 55 publications

Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes

Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes

Aging-Related Cellular, Structural and Functional Changes in the Lymph Nodes: A Significant Component of Immunosenescence? An Overview

Hemodynamic Responses in Lower Limb Lymphedema Patients Undergoing Physical Therapy

Contact Info

Product

Resources

About