Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin.

Jalkanen, Sirpa; Jalkanen, Markku

doi:10.1083/jcb.116.3.817

Cited by 497 publications

(280 citation statements)

References 57 publications

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“…It is, however, unclear how and what part of CD44 mediates these effects since not all of these can be attributed to the ability of CD44s to bind ECM component hyaluronic acid (HA) 29 or other ligands. [30][31][32][33][34][35] Here, the expression of CD44v on B cell lines from different stages of development and their potential role in adhesion to stromal cells from different tissues was investigated.…”

Section: Introductionmentioning

confidence: 99%

CD44 variant isoforms are involved in plasma cell adhesion to bone marrow stromal cells

Driel

Günthert²,

Kessel³

et al. 2002

Leukemia

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Expression of CD44v9-containing isoforms (CD44v9) on myeloma plasma cells correlates with unfavorable prognosis, suggesting that CD44 variant molecules are involved in the disease process. In this study, the presence of CD44v on B cell lines from different stages of development was analyzed by flow cytometry and a role in adhesion to stromal cells from different tissues was evaluated in in vitro binding assays. CD44v3, v6 and v9 isoforms were exclusively expressed on plasma cell lines and CD44v9 expression correlated with IL-6-dependent plasma cell growth. Binding studies using CD44 isoformspecific reagents showed that CD44v6 and CD44v9 were involved in binding to bone marrow stromal cells, but not to in vitro synthesized ECM or hyaluronic acid. CD44v9-mediated plasma cell binding resulted in a significant induction of IL-6 secretion by bone marrow stromal cells. Large differences in quantitative plasma cell binding to stromal cells from different tissues were observed. These, however, could not be related to a differential use of CD44v in these binding processes. The role of CD44v9 in adhesion induced IL-6 secretion and its preferential expression on IL-6-dependent plasma cell lines may explain the previously observed correlation between CD44v9 expression and adverse prognosis in multiple myeloma.

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Section: Introductionmentioning

confidence: 99%

CD44 variant isoforms are involved in plasma cell adhesion to bone marrow stromal cells

Driel

Günthert²,

Kessel³

et al. 2002

Leukemia

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“…Wheras the location of collagen interaction has not been described, binding to fibronectin is mediated via the chondroitin sulfate side chains, thus only the 180 -200kD CD44 form is able to bind to this ligand (Jalkanen and Jalkanen, 1992).…”

Section: Functional Implications Of the Cd44 Isoformsmentioning

confidence: 99%

“…Several functions have been attributed to the CD44 standard molecule, like binding to high endothelial venules (HEV; Jalkanen et al, 1988), binding to collagen and fibronectin (Carter and Wayner, 1988;Jalkanen and Jalkanen, 1992) and binding to hyaluronic acid (HA; Aruffo et al, 1990;Culty et al, 1990;Miyake et al, 1990). …”

Section: Functional Implications Of the Cd44 Isoformsmentioning

confidence: 99%

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CD44: A Multitude of Isoforms with Diverse Functions

Günthert¹

1993

Current Topics in Microbiology and Immunology

139

117

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“…It has been identified as the principal cell surface receptor for HA (1)(2)(3)(4)(5). CD44 has also been implicated in cell-cell adhesion and cell attachment to the extracellular matrix (3), cell migration (6), tissue remodeling (7), lymphocyte activation (8), recirculation, and homing (7). CD44 is broadly distributed, and it occurs in a standard isoform and in several isoforms (9) as alternatively spliced variant exonencoded gene products (10).…”

mentioning

confidence: 99%

Increase in the expression of the transmembrane surface receptor CD44v6 on chondrocytes in animals with osteoarthritis

Tibesku¹,

Szuwart²,

Ocken³

et al. 2005

Arthritis & Rheumatism

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Objective. To evaluate the expression of CD44v6 on chondrocytes from hyaline cartilage over the course of osteoarthritis (OA).Methods. In 12 NZW rabbits, the anterior cruciate ligament (ACL) was resected to create anterior instability of the knee. In 12 control rabbits, only a sham operation, without resection of the ACL, was performed. Four animals from each group were killed at 3, 6, and 12 weeks. After opening the knee joint, OA was macroscopically graded and hyaline cartilage of the load-bearing area was evaluated histologically according to the Mankin scale and by immunostaining for CD44v6.Results. There was a positive linear correlation between the time after surgery and the macroscopic and histologic OA scores. The scores in the control group were constant over the time course. Immunostaining showed constant expression of CD44v6 in the control group. In the experimental group, a positive linear correlation between CD44v6 expression and macroscopic and histologic grades was found.Conclusion. The results show an in vivo increase in the expression of the hyaluronan receptor CD44 over the time course of OA. Further studies are needed to evaluate whether this pattern applies to humans and whether new treatment approaches could evolve from this knowledge.

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Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin.

Cited by 497 publications

References 57 publications

CD44 variant isoforms are involved in plasma cell adhesion to bone marrow stromal cells

CD44 variant isoforms are involved in plasma cell adhesion to bone marrow stromal cells

CD44: A Multitude of Isoforms with Diverse Functions

Increase in the expression of the transmembrane surface receptor CD44v6 on chondrocytes in animals with osteoarthritis

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