2004
DOI: 10.1016/j.jaci.2003.12.017
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Lymphocytes in Peyer patches regulate clinical tolerance in a murine model of food allergy☆

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Cited by 69 publications
(66 citation statements)
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“…Several studies correlated oral tolerance with T regulatory cells (T reg) or clonal anergy/deletion, respectively, in response to low or high doses of fed antigens (2). In particular, CD4+CD25+ regulatory T cell clones have resulted inducible by the antigen in Peyer's patches of animal models (3). Since a natural outgrowth of cow's milk allergy has been associated with high blood levels of CD4+CD25+Foxp3+ T (reg) in children (4), we studied the role of this cell subset in ten selected children, before.…”
mentioning
confidence: 99%
“…Several studies correlated oral tolerance with T regulatory cells (T reg) or clonal anergy/deletion, respectively, in response to low or high doses of fed antigens (2). In particular, CD4+CD25+ regulatory T cell clones have resulted inducible by the antigen in Peyer's patches of animal models (3). Since a natural outgrowth of cow's milk allergy has been associated with high blood levels of CD4+CD25+Foxp3+ T (reg) in children (4), we studied the role of this cell subset in ten selected children, before.…”
mentioning
confidence: 99%
“…PP is found in sheep, calves, swine and horses in the ileum, while in the appendix in rabbits, and bursa in chickens 15 . Recent studies have indicated an interest in PP as an immune response mediator 15,16,17 , without giving importance to the distinct characteristics of the colonic tissue in evaluating the healing processes that take place on this structure. In the indexed literature, one single study makes mention of the collagen in this region 18 .…”
Section: Discussionmentioning
confidence: 99%
“…This observation reinforces the importance of experimental studies evaluating the healing of anastomoses in the left colon, especially studies using animals of only a single gender. Studies have habitually used animals of male gender [1][2][3][4][6][7][8][10][11][12][13]16,18 . even though there is no restriction on using females, purely from the point of view of location of the PP 5,14,21 .…”
Section: Discussionmentioning
confidence: 99%
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“…Our results showed clearly the development of hypersensitivity against the antigen administered (α-Lac). Frossaed et al [16] showed that the anaphylactic mice immunized with α-Lac exhibit a sharp increase in antibody titers IgG1 anti α-Lac and an increase in production of IL4. Our results showed that the ingestion of coconut milk leads to a significant decrease in the systemic immune response, as demonstrated by the low level of production of IgG antibodies to α-Lac.…”
Section: Evaluation Of Intestinal Villous Height Of Mice Fed With Cocmentioning
confidence: 99%