Lymphocytic Cholecystitis/Cholangitis

Jessurun, José

doi:10.1309/ajcp9q4qwzyygdna

Cited by 7 publications

(13 citation statements)

References 32 publications

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“…9 However, the intra-epithelial lymphocytes don't increase. 15 Follicular cholecystitis characterized by the presence of lymphoid follicles with germinal center. 10 Lymph Follicular cholecystitis is the other term used, which is associated with severe lymphocytic reaction.…”

Section: Discussionmentioning

confidence: 99%

“…A diagnostic criteria of an increased number of intraepithelial lymphocytes, which was taken as >30 lymphocytes/100 biliary cells in one study. 15 When such inflammatory pattern encountered in the stomach, colon, esophagus, and duodenum, it has been called lymphocytic gastritis, colitis, esophagitis, and duodenal lymphocytosis, respectively. 16 By analogy, the term lymphocytic cholecystitis was chosen for this condition.…”

Section: Discussionmentioning

confidence: 99%

“…The lamina propria may show lymphocytes to the extent to cause formation of papillae or infoldings which grossly could appear as polyp and thus the term lymphoid Polyp arose. 13,15 Lymphoid tissue in normal mucosa of the gall bladder is very sparse and lymphoid follicles are not seen. 10 In other study by Safia et al, the diagnosis of follicular cholecystitis was based upon the presence of >3 lymphoid follicle with germinal center in 1cm 2 area.…”

Section: Discussionmentioning

confidence: 99%

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Chronic cholecystitis with follicular lymphoid hyperplasia: nomenclature and diagnostic dilemmas

Vats¹,

Gupta²,

Mehendiratta³

et al. 2019

Int J Res Med Sci

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Background: To revisit the nomenclature, prevalence, histogenesis and the diagnostic dilemmas in cases of cholecystitis with lymphoid hyperplasia received in a private laboratory in one-year duration.Methods: A total of 51 cases of cholecystectomy were examined histopathologically to identify and review all the cases with emphasis on cholecystitis with marked lymphoid infiltration.Results: Out of 51 cholecystectomy specimens, some rare entities were observed such as 4 cases (8%) of xanthomatous change, 2 cases (4%) of cholecystitis with follicular lymphoid hyperplasia and a case of hyalinizing cholecystitis.Conclusions: The literature on cholecystitis with marked lymphoid infiltrate (with or without follicle formation) was overlapping and thus confusing. The same has been simplified with review of literature.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Chronic cholecystitis with follicular lymphoid hyperplasia: nomenclature and diagnostic dilemmas

Vats¹,

Gupta²,

Mehendiratta³

et al. 2019

Int J Res Med Sci

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“…Na doença de Still, patologia rara que cursa com CAA, a incidência da colecistite é extremamente incomum 10 . Colecistiteacalculosalinfocítica também apresenta-se como causa ainda mais rara, sem uma fisiopatologia conhecida, só sendo possivel seu diagnóstico pela imunohistopatologia 11 .…”

Section: Discussionunclassified

Colecistite aguda alitiásica em paciente pediátrico previamente hígido: relato de caso

Schio

França²,

Guimarães³

et al. 2016

Rev. Med. UFPR

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A colecistite acalculosa é uma inflamação da parede da vesicular biliar sem a presença de calculos, sendo responsável por 4 a 10% por cento dos casos de colecistite aguda. Objetivo: relatar um caso de CAA no serviço do HPP. Métodos: estudo restrospectivo de relato de caso. Discussão: Paciente de 13 anos, masculino, previamente hígido, admitido no HPP com quadro de dor em flanco direito, associada a náuseas, inapetência e diarréia líquida há 1 semana, com melhora parcial ao uso de analgésicos comuns (paracetamol e dipirona), porém com recorrência da dor. Realizou ultrassonografia de abdome total que mostrou colecistite aguda alitiásica e exames laboratorias com sinais inflamatórios. Paciente foi internado para tratamento conservador com antibioticoterapia. Apresentou resolução do quadro após 1 semana de tratamento, tendo alta hospitalar e sendo encaminhado para investigação ambulatorial. Conclusão: A CAA é uma patologia rara, de baixa prevalência na população geral e principalmente pediátrica. Deve-se suspeitar especialmente em pacientes críticos e hospitalizados por longos períodos, contudo, casos em pacientes previamente hígidos podem ser não tão infrequentes.

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“…[1][2][3] Thus, diverse microscopic inflammatory patterns have been characterized in cholecystectomy specimens in accordance with an increased awareness of the spectrum of disorders that manifest in the GB. 2,4 Follicular cholecystitis (FC) is considered a distinct type of chronic cholecystitis, described initially in patients with Salmonella infection in early 1900s. 5,6 Since then, it has been described in a limited number of case reports or small series with an incidence ranging from 0.08% to 11% of cholecystectomies.…”

Section: Introductionmentioning

confidence: 99%

Follicular Cholecystitis: Reappraisal of Incidence, Definition, and Clinicopathologic Associations in an Analysis of 2550 Cholecystectomies

et al. 2020

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Context. Follicular cholecystitis (FC) is a poorly characterized entity. Objective. To determine its frequency/clinicopathologic associations. Design. A total of 2550 cholecystectomy specimens were examined. Two hundred three of these were consecutive routine cholecystectomies submitted entirely for microscopic examination to determine the relative frequency of incidental pathologies in gallbladders (GBs). The remainder had representative sampling. Underlying conditions were nonobstructive pathologies (1270 nonspecific cholecystitis), obstructive (62 distal biliary tract tumors, 35 primary sclerosing cholangitis, and 31 autoimmune pancreatitis), and neoplastic (n = 949). FC was defined as 3 distinct lymphoid follicles (LFs)/centimeter. Results. In the GBs totally submitted for microscopic examination, the true frequency of FC was found to be 2.5% (5/203), and in the representatively sampled group, it was 1.9%, with similar frequencies in nonobstructive, obstructive, and neoplastic cases (2.3%, 3.1%, and 1.3%, respectively, P = .77). When the 39 FC in nonneoplastic GBs contrasted with ordinary chronic cholecystitis, they were associated with older age (68 vs 49 years, P < .0001), similar gallstone frequency (68 vs 81%), female/male ratio (2.7 vs 2.6), and wall thickness (4 mm for both). None had lymphoma/parasites/ Salmonella infection. Of 17 cases who had undergone gastric biopsy, 5 had chronic gastritis (2 with Helicobacter pylori). Microscopically, the LFs were the main inflammatory process often with minimal intervening inflammation. IgG4-positive plasma cell density was low (<10/high-power field) in 21/24(87.5%) cases. Conclusions. Follicular cholecystitis is seen in 2% of cholecystectomies, typically in significantly older patients, suggesting a deranged immune response. A third of the patients reveal biopsy-proven gastritis. FC does not seem to be associated with autoimmunity, lymphoma, or obstructive pathologies.

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Lymphocytic Cholecystitis/Cholangitis

Abstract: Objectives: To describe four cases of an uncommon type of acalculous cholecystitis/cholangitis characterized by increased intraepithelial lymphocytes within the biliary epithelium. Methods

Cited by 7 publications

References 32 publications

Chronic cholecystitis with follicular lymphoid hyperplasia: nomenclature and diagnostic dilemmas

Chronic cholecystitis with follicular lymphoid hyperplasia: nomenclature and diagnostic dilemmas

Colecistite aguda alitiásica em paciente pediátrico previamente hígido: relato de caso

Follicular Cholecystitis: Reappraisal of Incidence, Definition, and Clinicopathologic Associations in an Analysis of 2550 Cholecystectomies

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