Lymphocytolytic activity of glucocorticoids in vitro:51Cr release under equilibrium conditons

Glucocorticoid‐induced lymphocytolysis: State of the genetic analysis

“…A number of studies, recently reviewed by Munck and Leung [29], showing that many effects of glucocorticoids on sensitive lymphoid cells can be blocked by inhibitors such as actinomycin D and cycloheximide, suggest that RNA and protein synthesis may be required for the cytolytic response. Recently, these inhibitors have indeed been shown virtually to abolish the glucocorticoid-mediated lysis of rat thymic lymphocytes, as measured by "Cr release [30]. However, the identification of an mRNA or a protein induced by the steroid remains to be done, and this would be an important advance, because it would yield a biochemical assay for the response and could allow cloning of the glucocorticoid-induced gene (s).…”