Lymphoepithelial cyst - A sign of unappreciated HIV infection

Parotid lymphoepithelial cysts in human immunodeficiency virus: a review

“…15 Prior to the association between diffuse infiltrative lymphocytosis syndrome and HIV, diffuse infiltrative lymphocytosis syndrome was thought to be associated with Sjögren's syndrome (Table II). 7,15 Investigations Those diagnosed with parotid benign lymphoepithelial cysts, with or without systemic manifestations, should undergo tests for HIV infection. Other investigations might include fine needle aspiration cytology, imaging (e.g.…”

“…Computed tomography can demonstrate cervical lymphadenopathy in 100 per cent of cases. 7 However, these features are non-specific and are not diagnostic of benign lymphoepithelial cyst, and hence are used only as diagnostic adjuncts for surgery. 11 Histopathology Histopathology of benign lymphoepithelial cyst reveals a cystic wall formed of multi-layered squamous epithelium comprising germinal centres and dense lymphoid infiltrate.…”

“…The salivary glandular parenchyma adjacent to these cysts appears normal. 7,15 Immunoperoxidase studies Positivity for cytokeratin reveals the epithelial origin of benign lymphoepithelial cyst. Positive staining for cluster of differentiation antigens 45, 20, 79a and 3 indicates a lymphoid component to the cysts.…”

“…Prior to the association between diffuse infiltrative lymphocytosis syndrome and HIV, diffuse infiltrative lymphocytosis syndrome was thought to be associated with Sjögren's syndrome (Table II). 7 , 15…”

“…Multiple small cysts with enlarged parotid glands are usually observable on CT and MRI scans. Computed tomography can demonstrate cervical lymphadenopathy in 100 per cent of cases 7 . However, these features are non-specific and are not diagnostic of benign lymphoepithelial cyst, and hence are used only as diagnostic adjuncts for surgery 11 …”