Lymphoid Cell RNA's and Immunity

Gottlieb, Allan

doi:10.1016/s0079-6603(08)60108-7

Cited by 9 publications

(2 citation statements)

References 171 publications

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“…RNA release from eukaryote cells has been demonstrated 48, 57–68. In initial studies, macromolecular RNA was shown to pass between 3T3 cells in vitro 57.…”

Section: Introductionmentioning

confidence: 99%

The virtosome—a novel cytosolic informative entity and intercellular messenger

Gahan

Stroun²

2010

Cell Biochemistry & Function

121

111

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Studies on a range of prokaryote and eukaryote cells and tissues have shown that a newly synthesized DNA/RNA-lipoprotein complex is released in a regulated manner. This complex, termed a virtosome, is a novel cytosolic component of eukaryote cells. The released virtosomes can readily enter other cells where they can modify the biology of the recipient cells. Such modifications include immunological changes and transformation from normal to cancer cells. The virtosomes form a normal component of the circulating nucleic acids in plasma and serum currently used for clinical diagnostic purposes. Given the transformative powers of virtosomes released from tumour cells, the presence of such a complex in human plasma could readily offer the basis of an alternative mechanism for the initiation of metastases.

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“…RNA release from eukaryote cells has been demonstrated 48, 57–68. In initial studies, macromolecular RNA was shown to pass between 3T3 cells in vitro 57.…”

Section: Introductionmentioning

confidence: 99%

The virtosome—a novel cytosolic informative entity and intercellular messenger

Gahan

Stroun²

2010

Cell Biochemistry & Function

121

111

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“…Some 50 years ago, Garland demonstrated the uptake of RNA by ascites tumour cells whilst Bhargava and Shanmugam [132] and Gottlieb [133] reviewed numerous studies on immune RNA uptake. Kolodny [134,135] showed, in vitro, that living cells sequestered extra-cellular RNA so that an external constant level of RNA is maintained.…”

Section: Rna Uptake and Effects Upon Recipient Cellsmentioning

confidence: 99%

Biology of Circulating Nucleic Acids and Possible Roles in Diagnosis and Treatment in Diabetes and Cancer

Gahan

2012

IDDT

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The presence of DNA and RNA circulating in human plasma and serum is described. The possible sources of the DNA/RNA in blood, their ability to enter other cells and to express in the recipient cells are discussed and the relationship with metastases considered. The possible role(s) of the DNA/RNA in clinical diagnosis, in monitoring treatment and in prognosis are considered for diabetes and oncology.

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Leukocyte-Derived RNA as a Molecular Probe and Potential Immunotherapeutic Reagent

Waxman¹,

Baram²

1981

The Lymphokines

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Lymphoid Cell RNA's and Immunity

Cited by 9 publications

References 171 publications

The virtosome—a novel cytosolic informative entity and intercellular messenger

The virtosome—a novel cytosolic informative entity and intercellular messenger

Biology of Circulating Nucleic Acids and Possible Roles in Diagnosis and Treatment in Diabetes and Cancer

Leukocyte-Derived RNA as a Molecular Probe and Potential Immunotherapeutic Reagent

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