Lymphoid environment in triple-negative invasive ductal breast carcinoma

Abstract

Introduction. Triple-negative breast cancer (TNBC) is one of molecular subtypes breast cancer, about 10 to 20 percent of women with a breast cancer diagnosis have the triple-negative subtype, tumor doesn't have receptors for the estrogen, progesterone hormones, and doesn't express the protein HER2/neu, doesn't respond to the hormonal therapies and the Herceptin. TNBC has a poor prognosis, with higher grade and tends to spread, grows rapidly and occurs most often in younger women 40 or 50 years old and earlier. One of the promising scientific trends of modern oncology is the study of the role of the immune system in the pathogenesis of malignant tumors