Lymphoma cell isolation using multifunctional magnetic nanoparticles: antibody conjugation and characterization

Sahoo, Soubhagya Laxmi; Liu, Chi-Hsien; Wu, Wei‐Chi

doi:10.1039/c7ra02084h

Cited by 22 publications

(8 citation statements)

References 30 publications

(42 reference statements)

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“…[247,248] Additionally, antibody-functionalized superparamagnetic beads have been used to isolate rare cells from whole blood samples on microfluidic platforms. [249,250] Poudineh et al developed a unique microfluidic chip architecture that separates circulating tumor cells (CTCs) based on the level of interaction of antibody-functionalized magenetic beads within these cells. This device enabled phentoypic profiling of the CTCs in samples as dilute as 10 CTCs per mL of blood.…”

Section: Nanoparticlesmentioning

confidence: 99%

“…Certain nanocarriers, such as dye-based NPs, can be used for both diagnosis and therapy. [492,493] Many drug delivery platforms are designed Cancers [10,152,159,160,177,222,229,249,269,305,[368][369][370][371][372] to respond to endogenous and/or exogenous stimuli (e.g., pH, temperature, light, sound, ROS, enzymes, etc.) for controlled drug release.…”

Section: Clinical Applications Of Nanomaterials In Diagnosticsmentioning

confidence: 99%

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Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Welch

Powell

Clevinger

et al. 2021

Adv Funct Materials

115

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Nanoscale materials have unique properties that make them especially useful for biomedical diagnostic applications. Recent developments in nanoengineering have resulted in increasing use of nanostructures in biosensors. Various types of 0D, 1D, 2D, and 3D nanostructures have been used to improve biosensor sensitivity, selectivity, limit of detection, and time to result, among other metrics. These nanostructures have been integrated into electrochemical, optical, and other biosensors for this purpose. Here, the most recent advances in the use of nanostructured materials in biosensors are described. This includes a discussion of nanoparticles, nanorods, nanofibers, nanopillars, nanowires, nanosheets, indented nanopatterns (nanoholes and nanoslits), nanogaps, nanochannels, nanopores, nanofunctionalized surfaces, and complex hierarchical structures and their unique advantages and applications in biosensors. Clinical applications of these nanobiosensors are also highlighted along with a discussion of the future directions for these materials in diagnostics.

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Section: Nanoparticlesmentioning

confidence: 99%

Section: Clinical Applications Of Nanomaterials In Diagnosticsmentioning

confidence: 99%

Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Welch

Powell

Clevinger

et al. 2021

Adv Funct Materials

115

View full text Add to dashboard Cite

show abstract

“…Magnetic NPs characterized by having a high biocompatibility, stability, surface-to-volume ratio, binding-capacity and specificity were also successfully conjugated with anti-CD20 antibody to isolate lymphoma cells from biological fluids with an efficiency above the 95% [ 39 ]. At the same time, once functionalized with hyaluronic acids, they bound specifically to CD44 receptors, overexpressed in many types of leukemia and seized cancer cells from plasma samples.…”

Section: Nanoparticle-based Diagnosismentioning

confidence: 99%

Nanoparticles for hematologic diseases detection and treatment

2019

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Nanotechnology, as an interdisciplinary science, combines engineering, physics, material sciences, and chemistry with the biomedicine knowhow, trying the management of a wide range of diseases. Nanoparticle-based devices holding tumor imaging, targeting and therapy capabilities are formerly under study. Since conventional hematological therapies are sometimes defined by reduced selectivity, low therapeutic efficacy and many side effects, in this review we discuss the potential advantages of the NPs’ use in alternative/combined strategies. In the introduction the basic notion of nanomedicine and nanoparticles’ classification are described, while in the main text nanodiagnostics, nanotherapeutics and theranostics solutions coming out from the use of a wide-ranging NPs availability are listed and discussed.

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“…CD20 antibody (rituximab) has been applied to the treatment of lymphoma but it can also be used for lymphoid neoplasms diagnosis. Sahoo et al ( 2017 ) used avidin-modified magnetic NPs (MNPs) functionalized with biotinylated anti-CD20 antibody and a permanent magnet to specifically detect and isolate lymphoma cells from mixed samples. Capolla and colleagues also used an anti-CD20 antibody functionalized into polymeric-fluorophore Cy5.5-labeled NPs for in vivo imaging directed at the diagnosis of B-cell malignancies.…”

Section: Nps Applications In Liquid Tumorsmentioning

confidence: 99%

Nanoparticles—Emerging Potential for Managing Leukemia and Lymphoma

Vinhas

Mendes

Fernandes

et al. 2017

Front. Bioeng. Biotechnol.

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Nanotechnology has become a powerful approach to improve the way we diagnose and treat cancer. In particular, nanoparticles (NPs) possess unique features for enhanced sensitivity and selectivity for earlier detection of circulating cancer biomarkers. In vivo, NPs enhance the therapeutic efficacy of anticancer agents when compared with conventional chemotherapy, improving vectorization and delivery, and helping to overcome drug resistance. Nanomedicine has been mostly focused on solid cancers due to take advantage from the enhanced permeability and retention (EPR) effect experienced by tissues in the close vicinity of tumors, which enhance nanomedicine’s accumulation and, consequently, improve efficacy. Nanomedicines for leukemia and lymphoma, where EPR effect is not a factor, are addressed differently from solid tumors. Nevertheless, NPs have provided innovative approaches to simple and non-invasive methodologies for diagnosis and treatment in liquid tumors. In this review, we consider the state of the art on different types of nanoconstructs for the management of liquid tumors, from preclinical studies to clinical trials. We also discuss the advantages of nanoplatforms for theranostics and the central role played by NPs in this combined strategy.

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Lymphoma cell isolation using multifunctional magnetic nanoparticles: antibody conjugation and characterization

Abstract: The early detection of B-cell lymphoma cells using multifunctional magnetic nanoparticles has a wide impact on the diagnosis of lymphoma patients.

Cited by 22 publications

References 30 publications

Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Nanoparticles for hematologic diseases detection and treatment

Nanoparticles—Emerging Potential for Managing Leukemia and Lymphoma

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