Lymphomas diagnosed in an internal medicine department compared to lymphomas diagnosed in other departments

Pernot, Benoit; Gyan, Emmanuel; Maillot, F.; Hodges, Penelope; Ertault, Marjan; Ferreira-Maldent, Nicole

doi:10.1097/md.0000000000013228

Cited by 4 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Likewise, Vincristine is also a Vinca alkaloid that occurs naturally and is an organic molecule [ 97 ]. This alkaloid (vincristine drug) acts as an anti-microtubule agent that blocks mitosis by blocking cells in the metaphase [ 95 , 98 ].…”

Section: Anticancer/cytotoxic Potential Of Alkaloids: Pharmacological...mentioning

confidence: 99%

“…Acute lymphocytic leukemia, lymphoid blast crisis of chronic myeloid leukemia, and Hodgkin and Non-Hodgkin lymphoma are among the applications for vincristine approved by the US Food and Drug Administration (FDA). Central nervous system malignancies, Ewing sarcoma, prenatal trophoblastic tumours, multiple myeloma, ovarian cancer, and small cell lung cancer are among the off-label applications of vincristine [ 97 , 98 ].…”

Section: Anticancer/cytotoxic Potential Of Alkaloids: Pharmacological...mentioning

confidence: 99%

See 1 more Smart Citation

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

et al. 2022

View full text Add to dashboard Cite

Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with others, which not only put a tremendous economic effect on patients but also develop drug resistance in patients with time. A significant number of cancer cases can be prevented/treated by implementing evidence-based preventive strategies. Plant-based drugs have evolved as promising preventive chemo options both in developing and developed nations. The secondary plant metabolites such as alkaloids have proven efficacy and acceptability for cancer treatment. Apropos, this review deals with a spectrum of promising alkaloids such as colchicine, vinblastine, vincristine, vindesine, vinorelbine, and vincamine within different domains of comprehensive information on these molecules such as their medical applications (contemporary/traditional), mechanism of antitumor action, and potential scale-up biotechnological studies on an in-vitro scale. The comprehensive information provided in the review will be a valuable resource to develop an effective, affordable, and cost effective cancer management program using these alkaloids.

show abstract

Section: Anticancer/cytotoxic Potential Of Alkaloids: Pharmacological...mentioning

confidence: 99%

Section: Anticancer/cytotoxic Potential Of Alkaloids: Pharmacological...mentioning

confidence: 99%

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Vindoline, vinblastine’s chemo predecessor, is also effective against cancer and is derived from tabersonine [ 85 ]. Vincristine, like vincamine, is a naturally occurring organic compound derived from the vinca plant [ 107 ]. To prevent cells from entering mitosis, this alkaloid (vincristine) functions as an anti-microtubule agent [ 102 , 108 ].…”

Section: Mechanisms Of Cancer Chemopreventionmentioning

confidence: 99%

“…Vincristine has been licensed by the US Food and Drug Administration (FDA) for the treatment of Hodgkin’s disease and Hodgkin’s non-lymphoma, acute lymphocytic leukemia, and the lymphoid blast crisis of chronic myeloid leukemia. Vincristine has been used off-label to treat a variety of cancers, including those of the central nervous system [ 107 , 108 ], Ewing sarcoma, prenatal trophoblastic tumors, multiple myeloma, ovarian cancer, and small cell lung cancer.…”

Section: Mechanisms Of Cancer Chemopreventionmentioning

confidence: 99%

Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and Inflammation

Ahmed

Islam

Alghamdi

et al. 2022

IJMS

View full text Add to dashboard Cite

Cancer is one of the deadliest non communicable diseases. Numerous anticancer medications have been developed to target the molecular pathways driving cancer. However, there has been no discernible increase in the overall survival rate in cancer patients. Therefore, innovative chemo-preventive techniques and agents are required to supplement standard cancer treatments and boost their efficacy. Fruits and vegetables should be tapped into as a source of compounds that can serve as cancer therapy. Phytochemicals play an important role as sources of new medication in cancer treatment. Some synthetic and natural chemicals are effective for cancer chemoprevention, i.e., the use of exogenous medicine to inhibit or impede tumor development. They help regulate molecular pathways linked to the development and spread of cancer. They can enhance antioxidant status, inactivating carcinogens, suppressing proliferation, inducing cell cycle arrest and death, and regulating the immune system. While focusing on four main categories of plant-based anticancer agents, i.e., epipodophyllotoxin, camptothecin derivatives, taxane diterpenoids, and vinca alkaloids and their mode of action, we review the anticancer effects of phytochemicals, like quercetin, curcumin, piperine, epigallocatechin gallate (EGCG), and gingerol. We examine the different signaling pathways associated with cancer and how inflammation as a key mechanism is linked to cancer growth.

show abstract

“…The vinca alkaloids are important for being anticancer drugs like vincristine and vinblastine. The productivity of vinblastine and vincristine is very low in plants (0.001-0.0003%) resulting in their extraordinary high price [2] . The United States Food and Drug Administration (FDA) approved indications of vincristine are acute lymphocytic leukemia, lymphoid blast crisis of chronic myeloid leukemia and Hodgkin and Non-Hodgkin lymphoma [3] .…”

Section: Introductionmentioning

confidence: 99%

Vincristine: Beyond on anticancer treatment

Tiwari¹,

Tiwari²

2020

Int. J. Pharmacognosy Life Sci.

View full text Add to dashboard Cite

Vincristine is a chemotherapeutic agent that is a component of many combination regimens for a variety of malignancies, including several common pediatric tumors.78% of patients with advanced malignant disease were treated with vincristine, an alkaloid derived from vinca rosea Linn, 59% of these survived from the beginning of treatment and could be evaluated. Favourable responses were seen in patients with Hodking's disease, reticulum cell sarcoma, lymphosarcoma, carcinoma of the breast, acute leukemia and choriocarcinoma. Toxic include a high incidence of alopecia and neurologic complications. Vincristine treatment is limited by a progressive sensorimotor peripheral neuropathy. Vincristine-induced peripheral neuropathy (VIPN) is particularly challenging to detect and monitor in pediatric patients, in whom the side effect can diminish long term quality of life. Further research is needed to predict, prevent, and treat disease to maximize therapeutic benefit and avoid unnecessary toxicity from vincristine treatment.

show abstract

Lymphomas diagnosed in an internal medicine department compared to lymphomas diagnosed in other departments

Abstract: Supplemental Digital Content is available in the text

Cited by 4 publications

References 31 publications

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and Inflammation

Vincristine: Beyond on anticancer treatment

Contact Info

Product

Resources

About