Lymphomes spléniques : diagnostic et prise en charge

Riller, Quentin; Cohen‐Aubart, Fleur; Roos‐Weil, Damien

doi:10.1016/j.revmed.2022.05.009

Cited by 2 publications

(1 citation statement)

References 61 publications

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“…The ideal treatment for splenic cell-B lymphoma is unclear since there are to date no randomized studies for such a rare neoplasia 19 . The current consensus is splenectomy with rituximab in monotherapy or combined with other chemotherapics.…”

Section: Discussionmentioning

confidence: 99%

Splenic cyst deroofing complicated with B lymphoma

De Quirós,

Jiménez-Romero,

Suárez

et al. 2024

Preprint

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Background: Splenic cysts are uncommon and very rarely malignant therefore their treatment isn’t standardised. In case of symptomatic cysts different surgical approaches have been suggested. Primary malignant lymphoma of the spleen comprises less than 1% of non-Hodgkin’s lymphomas. To our knowledge, only 203 cases of splenic large B-cell lymphoma (LBCL) have been reported to date and only 2 of them were fibrin-associated splenic cysts. Case presentation: 27-year-old model with a 19x13cm splenic cyst without data of malignancy in the preliminary study and therefore treated with laparoscopic deroofing. After histological diagnosis of LBCL with a fibrin/EVB-associated splenic pseudocyst the patient received 4 cycles of Rituximab and a laparoscopic splenectomy was performed due to resurgence of the pseudocyst. No evidence of malignancy has been found in controls performed after the splenectomy. Discussion and Conclusions: the value of tumour markers and radiology for diagnosis of splenic cysts is put into question. Only 60 cases of Fibrin-associated LBCL (FA-LBCL) have been described in the literature therefore there are no treatment guidelines for them even though surgery together with systemic treatment has been the prevalent route with good results in most cases.

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Section: Discussionmentioning

confidence: 99%

Splenic cyst deroofing complicated with B lymphoma

De Quirós,

Jiménez-Romero,

Suárez

et al. 2024

Preprint

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Generalized lymphadenopathy as the first clinical manifestations of systemic lupus erythematosus–A case report

Nazir,

Muhamad,

Yudin

2024

ELECTRON J GEN MED

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Generalized lymphadenopathy is a non-specific symptom of many diseases including infections, inflammations, malignancies, or autoimmune diseases. The presence of lymphadenopathy in systemic lupus erythematosus (SLE) is often associated with active disease and it’s rarely present without SLE symptoms. We presented a case of 24 years old postnatal female who experienced of prolonged fever, weight loss, constitutional symptoms, and generalized lymphadenopathy for two months. In view of no suggestive symptoms of infections, connective tissue disease and other malignancies, our major concern was lymphoma. However, over time, diagnosis of SLE was made based on late manifestations of musculoskeletal, hematological, neuropsychiatric, and renal symptoms of lupus supported by positive autoimmune investigations. This case highlighted how SLE first manifests as generalized lymphadenopathy followed by late manifestations of other symptoms. The vague symptoms of SLE make the diagnosis challenging.

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Lymphomes spléniques : diagnostic et prise en charge

Cited by 2 publications

References 61 publications

Splenic cyst deroofing complicated with B lymphoma

Splenic cyst deroofing complicated with B lymphoma

Generalized lymphadenopathy as the first clinical manifestations of systemic lupus erythematosus–A case report

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