Lymphopenia and Change in Distribution of Human B and T Lymphocytes in Peripheral Blood Induced by Irradiation for Mammary Carcinoma

Stjernswärd, Jan; Vánky, Farkas; Jondal, Mikael; Wigzell, Hans; Sealy, R.

doi:10.1016/s0140-6736(72)91091-4

Cited by 420 publications

(82 citation statements)

References 24 publications

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“…Similar effects have been observed after local radiotherapy (Thomas et al, 1971;Stjernsward et al, 1973;Chee, Ilberry and Rickinson, 1974) Surgery.-The primary tumour was excised in patients with stage I skin melanoma. Stage II patients were treated by local excision of the primary and dissection of the draining lymph nodes.…”

Section: Methodsmentioning

confidence: 60%

The influence of tumour burden and therapy on cellular cytotoxicity responses in patients with ocular and skin melanoma

Unsgaard¹,

O’Toole²

1975

Br J Cancer

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Using a microassay for cellular immunity, tumour specific cytotoxicity was detected in 2/5 cases of ocular melanoma and 1/3 cases of primary cutaneous melanoma before treatment. Reactivity was measured against allogeneic skin melanoma target cells in short or long term in vitro culture. Lymphoid cells from patients with disseminated cutaneous melanoma were either non-reactive (4/8 cases) or gave a nonspecific cytotoxicity on target cells of diverse histogenic origins. Among tumour-free patients tested after surgery, 0/2 patients with ocular tumour were non-reactive 3-4 months post surgery. After sugical excision of cutaneous melanoma 2/2 patients gave tumour specific reactions during the first month after surgery. After longer time intervals, from 5 months to 3 years, only 1/8 patients were reactive. Preoperative radiotherapy in a total skin dose of 10,000 rad produ-ed a transient tumour specific reaction 24 h after therapy in a single case. Following local tumour excision in patients given preoperative irradiation, 2 cases which had previously demonstrated tumour specific CMI lost reactivity. Among 14 tumour-free individuals tested only after preoperative radiotherapy and surgery, at intervals from 5 day to 13 years, a single case gave tumour specific CMI. Palliative irradiation in doses 4000-4960 rad to the inguinal or axillary lymph nodes was found to induce a generalized lymphopenia within 48 h after treatment. Lymphoid cell preparations from patients with localized melanoma contained significantly increased numbers of immature cells (lymphoblasts and myeloblasts) and myeloid precursor elements. Those prepared from patients with disseminated disease had in addition elevated levels of eosinophils but reduced numbers of recoverable lymphocytes.

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Section: Methodsmentioning

confidence: 60%

The influence of tumour burden and therapy on cellular cytotoxicity responses in patients with ocular and skin melanoma

Unsgaard¹,

O’Toole²

1975

Br J Cancer

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“…The two methods gave comparable results (Table I) (Meyer, 1970;McCredie, Inch and Sutherland, 1972) and reduced PHA induced blast transformation (Stjernsward et al, 1972) In the 7 day tests, 47% of patients reacted to autologous and 40% to allogeneic breast tumour antigens; 28/45 (62%) patients positive to autologous antigens also reacted to allogeneic tumour preparations, while only 7143 (16%) patients negative to autologous antigens cross-reacted with allogeneic tumours (P < 0-001, Chi-squared with Yates' correction). This might indicate that negative in vitro results truly indicated a lack of reactivity on the part of the patient and were not due to variations in the fractionation of tumours.…”

Section: Resultsmentioning

confidence: 90%

Horizontal studies of cell mediated immune reactions to autologous tumour antigens in patients with operable mammary carcinoma

Jones¹,

Turnbull²

1975

Br J Cancer

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Summary.-The leucocyte migration and guinea-pig macrophage migration procedures were used to assess cell mediated, tumour directed immune reactions in patients with mammary carcinoma undergoing simple mastectomy with or without post-operative irradiation. Forty-seven per cent of patients reacted to autologous tumour antigens and 40o% to allogeneic antigens when tested 7 days after operation; 23% reacted to autologous antigens at 2 months, 19% at 6 months and 34%0 at 1 year after surgery. Reactions to benign tissue fractions were rare. Better discrimination between test and control subjects was obtained when 3000 g sediments rather than nuclei-depleted homogenates (extracts) were used. Irradiation 3-7 weeks postoperatively did not depress the in vitro response at 2 months and yielded a higher rate of positive reactions at 6 months. Correlations of serial LMT responses with certain clinical findings are discussed.

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“…However, at the completion of treatment, the mean total lymphocyte count of 503/mm3 was 4 SD below the mean for normal controls. Acute lymphocytopenia after a course of radiation has been described in a variety of clinical situations involving localized or extended field radiotherapy (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Recovery usually begins shortly after completion of treatment (6,7,12), and continues through the next 1-2 yr.…”

Section: Introductionmentioning

confidence: 99%

Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease.

Fuks¹,

Strober²,

Bobrove³

et al. 1976

J. Clin. Invest.

269

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Lymphopenia and Change in Distribution of Human B and T Lymphocytes in Peripheral Blood Induced by Irradiation for Mammary Carcinoma

Cited by 420 publications

References 24 publications

The influence of tumour burden and therapy on cellular cytotoxicity responses in patients with ocular and skin melanoma

The influence of tumour burden and therapy on cellular cytotoxicity responses in patients with ocular and skin melanoma

Horizontal studies of cell mediated immune reactions to autologous tumour antigens in patients with operable mammary carcinoma

Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease.

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