Lymphoreticular Disorders, Thymoma, and Other Neoplastic Diseases

Quesenberry, Katherine E.; Pilny, Anthony A.; St-Vincent, Rachel S.

doi:10.1016/b978-0-323-48435-0.00020-4

Cited by 4 publications

(4 citation statements)

References 67 publications

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“…Besonders bei jungen Tieren wird eine Neoplasie oft unterdiagnostiziert und eine genaue Diagnosestellung kann herausfordernd sein. Lymphome können Patienten jeden Alters betreffen, allerdings sind die Patienten zum Zeitpunkt der Diagnose häufig unter 2 Jahre alt, das heißt, es ist eine der häufigsten Tumorarten bei Jungtieren [1].…”

Section: Lymphatische Neoplasien Beim Kaninchenunclassified

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Das Lymphom beim Kaninchen – ein Überblick zur Erkrankung mit klinischem Fall

Puho

2023

veterinär spiegel

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Section: Lymphatische Neoplasien Beim Kaninchenunclassified

“…Beim Kaninchen gibt es mehrere Lymphom-Subtypen mit einer höheren Prävalenz von großzelligen B-Zell-Lymphomen. In der Literatur wurden nur gelegentlich zu Lymphomen bei Kaninchen Fallberichte dokumentiert und wenige Fälle von lymphatischer Neoplasie beim Kaninchen vor den 1960er Jahren publiziert 1 , 2 .…”

Section: Lymphatische Neoplasien Beim Kaninchenunclassified

Das Lymphom beim Kaninchen – ein Überblick zur Erkrankung mit klinischem Fall

Puho

2023

veterinär spiegel

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“…As thymomas are radiation‐responsive tumours and may shrink rapidly after irradiation, adaptive radiotherapy (ART) warrants further investigation. There is often a rapid clearance of the lymphocytes in the thymoma by apoptosis, likely within the first few weeks after the start of radiation therapy 17,18 . ART allows for altering the treatment plan during therapy based on imaging, in order to develop a plan that is individualized to current size of the thymoma 19 .…”

Section: Introductionmentioning

confidence: 99%

“…There is often a rapid clearance of the lymphocytes in the thymoma by apoptosis, likely within the first few weeks after the start of radiation therapy. 17,18 ART allows for altering the treatment plan during therapy based on imaging, in order to develop a plan that is individualized to current size of the thymoma. 19 The goals of adaptive radiation therapy are to improve dose delivery and tumour control, decrease the dose to normal tissues, and hopefully reduce the risk of acute and late side effects.…”

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confidence: 99%

Adaptive radiation therapy using weekly hypofractionation for thymoma treatment: A retrospective study of 10 rabbits

McCready

Poirier

Fleck

et al. 2022

Vet Comparative Oncology

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Radiation therapy (RT) is being utilized more commonly for rabbit thymomas due to high perioperative mortality rates with surgery. Median overall survival times reported for rabbit thymomas treated with a variety of RT protocols and techniques range from 6 months to greater than 2 years. As thymomas are radiation‐responsive tumours and may shrink rapidly after RT, adaptive radiotherapy (ART) is often warranted. The purpose of this single‐institution retrospective case series was to investigate the tumour volume reduction during RT, the frequency of replanning during RT, and survival time in rabbit thymomas treated using intensity‐modulated/image‐guided radiation therapy (IMRT/IGRT) and a weekly hypofractionated protocol delivering a total dose of 30 Gy. Ten rabbits met the inclusion criteria from October 2014 to October 2019. The median progression‐free survival was 561 days and the median overall survival was 634 days (range: 322–1118 days). The tumour volume gradually decreased with each RT fraction. On post‐hoc analysis, only the first RT fraction was associated with a significant GTV reduction (of more than 50% on average, p < .001). All subsequent RT fractions did not further reduce the GTV significantly (p > .06). Hypofractionated RT using a weekly protocol of 5 fractions of 6 Gy is a reasonable option to treat rabbit thymomas and replanning should be anticipated. The results of this study support the use of RT to rapidly relieve thymoma‐induced dyspnoea in rabbits.

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Rabbits

DeCubellis¹,

Graham

2021

Exotic Animal Emergency and Critical Care Medicine

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Lymphoreticular Disorders, Thymoma, and Other Neoplastic Diseases

Cited by 4 publications

References 67 publications

Das Lymphom beim Kaninchen – ein Überblick zur Erkrankung mit klinischem Fall

Das Lymphom beim Kaninchen – ein Überblick zur Erkrankung mit klinischem Fall

Adaptive radiation therapy using weekly hypofractionation for thymoma treatment: A retrospective study of 10 rabbits

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