Lymphoscintigraphy in Oral Squamous Cell Carcinoma Sentinel Node Biopsy and Its Role in the Surgical Planning

Sabaté‐Llobera, Aida; Benítez-Segura, A.; Bernat, Antonio Ricardo Marí; Arranz, C.; Bajén, M.T.; Maymó-Garrido, Sandra; Martín-Comín, J.

doi:10.1097/rlu.0b013e3182a755a9

Cited by 9 publications

(5 citation statements)

References 15 publications

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“…We believe one of the advantages is to identify the individual drainage pattern of these tumours, especially outside the field normally dissected in a traditional ipsilateral supraomohyoid neck dissection. In the head and neck, individual lymphatic drainage can be unpredictable, and our results are concordant with similar studies, which demonstrate that 10–30% of unilateral OCSCC drain bilaterally or to the contralateral neck with 40% of midline tumours draining unilaterally . In a study by Broglie et al ., 15% of lesions localized to the ipsilateral level 4, of which 8% were positive .…”

Section: Discussionsupporting

confidence: 92%

“…In the head and neck, individual lymphatic drainage can be unpredictable, and our results are concordant with similar studies, which demonstrate that 10-30% of unilateral OCSCC drain bilaterally or to the contralateral neck 1,10 with 40% of midline tumours draining unilaterally. 15 In a study by Broglie et al, 15% of lesions localized to the ipsilateral level 4, of which 8% were positive. 10 These results suggest that the addition of lymphatic mapping when staging the neck for OCSCC may improve the nodal yield and reduce the morbidity of surgery.…”

Section: Discussionmentioning

confidence: 94%

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Sentinel lymph node biopsy for early oral cancers: Westmead Hospital experience

Abdul-Razak

Chung

Wong

et al. 2016

ANZ Journal of Surgery

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 94%

Sentinel lymph node biopsy for early oral cancers: Westmead Hospital experience

Abdul-Razak

Chung

Wong

et al. 2016

ANZ Journal of Surgery

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“…The detection rate of lymphoscintigraphy is ~90–97%, which is similar to that reported in the majority of literature ( 15 , 16 ), indicating that the use of a γ probe in lymphoscintigraphy may provide accurate SLN localization for SLNB. However, the SLN imaging of the patients conducted using lymphoscintigraphy is not fully developed.…”

Section: Discussionsupporting

confidence: 85%

99mTc-dextran lymphoscintigraphy can detect sentinel lymph node in breast cancer patients

Wei

Chen

Zhang

et al. 2014

Experimental and Therapeutic Medicine

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The aim of this study was to retrospectively determine the accuracy and feasibility of using 99mTc-dextran (DX) lymphoscintigraphy for the localization of sentinel lymph nodes (SLNs) in breast cancer patients. The relevant factors affecting lymphoscintigraphy were also investigated. In this study, 235 breast cancer patients underwent 99mTc-DX lymphoscintigraphic imaging and examination by a γ-probe method in combination with blue dye staining to detect SLNs. The detection results were considered in combination with rapid frozen pathology results to determine whether SLN metastasis was positive or negative. SLNs were identified in 191 patients by γ-probe detection among the 202 patients that tested positive by lymphoscintigraphic imaging, a coincidence rate of 94.6%. This suggested that lymph node metastasis had occurred and could be detected using lymphoscintigraphy. The axillary status of the breast cancer patients was also predicted using lymphoscintigraphy and the false-negative rate, sensitivity, specificity and positive predictive value were 13.3% (4/30), 90.7% (39/43), 23.4% (45/192) and 13.5% (21/155), respectively. The age of the patient, menstrual status, tumor location, tumor size, pathological type, preoperative biopsy and neoadjuvant chemotherapy were unrelated to the success of lymphoscintigraphy (P>0.05). 99mTc-DX lymphoscintigraphy is able to exactly determine the location of SLN in breast cancer patients, and can be used for guiding γ-probe methods and sentinel lymph node biopsy.

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“…Two authors individually collected data from included articles in forms commensurate with each other. Diagnostic accuracy, represented by DOR, summary receiver operating characteristic (SROC) curve, and area under the curve (AUC), was calculated 1,5,11–102 . DOR was calculated as (true positive [TP]/false positive [FP])/(false negative [FN]/true negative [TN]) to assess diagnostic accuracy with 95% confidence intervals (CIs).…”

Section: Methodsmentioning

confidence: 99%

Usefulness of Sentinel Lymph Node Biopsy for Oral Cancer: A Systematic Review and Meta‐Analysis

Kim

et al. 2020

The Laryngoscope

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Objective We assessed the diagnostic accuracy of sentinel lymph node biopsy (SLNB) for detecting neck nodal metastasis in early oral squamous cell carcinoma (OSCC) as an alternative to elective neck dissection. Study Design A systematic search for relevant literature was conducted in the PubMed, SCOPUS, Embase, Web of Science, and Cochrane databases. Methods Two reviewers individually searched the five databases up to November 2019. For studies that met inclusion criteria, data on patient diagnoses were pooled, including true positives, true negatives, false positives, and false negatives. Methodological quality was checked with the Quality Assessment of Diagnostic Accuracy Studies (version 2) tool. Results In total, 98 observational or retrospective studies were included. The diagnostic odds ratio of SLNB was 326.165 (95% confidence interval [CI]: 231.477–459.587; I2 = 0%). The area under the summary receiver operating characteristic curve was 0.982. Sensitivity was 0.827 (95% CI: 0.804–0.848), and specificity was 0.981 (95% CI: 0.975–0.986). The correlation between sensitivity and the false positive rate was −0.076, which indicates that heterogeneity did not exist. Subgroup analyses were performed with the subgroups reference test type, publication year, and study type. No significant difference was found within the reference test type subgroup. However, differences within the publication year and study type subgroups were significant, where the retrospective study subgroup was significantly more sensitive and specific than the prospective study subgroup. Conclusion Results of this meta‐analysis imply that the high specificity of SLNB supports its role as a diagnostic tool for patients with clinical tumor stage (CT)1‐2 clinically negative (N0) OSCC. More studies should be done to further verify the results of this study. Level of Evidence 2a Laryngoscope, 131:E459–E465, 2021

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Lymphoscintigraphy in Oral Squamous Cell Carcinoma Sentinel Node Biopsy and Its Role in the Surgical Planning

Abstract: These results support the reliability of sentinel node biopsy in OSCC. Presurgical lymphoscintigraphy is essential, because it can modify the surgical procedure.

Cited by 9 publications

References 15 publications

Sentinel lymph node biopsy for early oral cancers: Westmead Hospital experience

Sentinel lymph node biopsy for early oral cancers: Westmead Hospital experience

99mTc-dextran lymphoscintigraphy can detect sentinel lymph node in breast cancer patients

Usefulness of Sentinel Lymph Node Biopsy for Oral Cancer: A Systematic Review and Meta‐Analysis

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