Lyn deficiency in B cells from patients with systemic lupus erythematosus: Comment on the article by Flores‐Borja et al

Liossis, Stamatis–Nick C.; Solomou, Elena E.; Sikakis, Petros P.

doi:10.1002/art.21878

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…No association between any Lyn variants and disease has been identified in populations of African or Asian ancestry, nor has there been any association with changes in protein or transcript levels . However, data from SLE patients have shown them to have lower levels of Lyn compared to healthy controls, implying that lower levels may be associated with disease . In addition, studies in B cell lines show that Lyn is required for inhibitory signals in response to weak BCR crosslinking .…”

Section: Variants Affecting B Cell Signaling Molecules Affect Both Pementioning

confidence: 99%

Review: Abnormal B Cell Development in Systemic Lupus Erythematosus: What the Genetics Tell Us

Karrar

Graham

2018

Arthritis & Rheumatology

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Section: Variants Affecting B Cell Signaling Molecules Affect Both Pementioning

confidence: 99%

Review: Abnormal B Cell Development in Systemic Lupus Erythematosus: What the Genetics Tell Us

Karrar

Graham

2018

Arthritis & Rheumatology

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“…Although double-blind studies have not been reported, the experience in SS follows the pattern of treatment often used in ILD involvement in PSS patients. Namely, patients may receive intravenous cyclophosphamide monthly for up to 6 months [88], followed by mycophenolic acid (mofetil) [89] in an effort to taper the corticosteroids. Patients with hypoxemia may be given supplemental oxygen and may be considered for lung transplant.…”

Section: Interstitial Pneumonitismentioning

confidence: 99%

Extraglandular Manifestations of Sjögren’s Syndrome (SS): Dermatologic, Arthritic, Endocrine, Pulmonary, Cardiovascular, Gastroenterology, Renal, Urology, and Gynecologic Manifestations

Fox

2011

Sjögren’s Syndrome

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Primary Sjögren's syndrome (1 • SS) is an autoimmune disorder characterized by dry eyes (keratoconjunctivitis sicca) and dry mouth due to lymphocytic infiltrates of lacrimal and salivary glands. However, SS also affects many extraglandular systems. In SS patients, the pattern of extraglandular manifestations may have a close similarity with the vasculitic features seen in SLE patients that are mediated by immune complexes and complement. However, SS patients also have an increased frequency of lymphocytic infiltration into extraglandular tissues, as might be expected by their increased frequency of lymphoma in comparison to SLE patients. For example, SS patients need to be evaluated for interstitial nephritis (in contrast to the glomerulonephritis of SLE) or interstitial pneumonitis (in comparison to pleurisy of SLE). This chapter will focus on the clinical extraglandular manifestations of primary SS that are not specifically covered in other chapters. These extraglandular manifestations have led to a recently introduced "disease activity" and "organ damage index." The recognition of these extraglandular manifestations is important since they have prognostic and therapeutic implications. The differential diagnosis of these extraglandular manifestations includes overlapping features with other autoimmune diseases (particularly systemic lupus erythematosus (SLE), scleroderma, dermatomyositis, celiac sprue, and small-and medium-sized vessel vasculitis), infectious diseases that mimic autoimmune disease (particularly hepatitis C, HIV, syphilis, tuberculosis), and predisposition to drug toxicities that may involve extraglandular organs (particularly skin rashes, nephritis, pneumonitis, myositis, and hematopoietic abnormalities). R.I. Fox ( )

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Lyn deficiency in B cells from patients with systemic lupus erythematosus: Comment on the article by Flores‐Borja et al

Cited by 2 publications

References 6 publications

Review: Abnormal B Cell Development in Systemic Lupus Erythematosus: What the Genetics Tell Us

Review: Abnormal B Cell Development in Systemic Lupus Erythematosus: What the Genetics Tell Us

Extraglandular Manifestations of Sjögren’s Syndrome (SS): Dermatologic, Arthritic, Endocrine, Pulmonary, Cardiovascular, Gastroenterology, Renal, Urology, and Gynecologic Manifestations

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