Lyotropic liquid crystal systems in drug delivery: a review

Kim, Dong Hwan; Jahn, A.; Cho, Sung‐Joon; Kim, Jung Sun; Ki, Min-Hyo; Kim, Dae‐Duk

doi:10.1007/s40005-014-0165-9

Cited by 105 publications

(49 citation statements)

References 74 publications

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“…Potassium diclofenac, which is the least chaotropic diclofenac salt derivative, had a less pronounced effect on the mesophase structure. As expected, sodium salt (kosmotropic) had the least influence on both lamellar and cubic mesophases [ 115 ].…”

Section: Release Absorption and Permeation Mechanismsupporting

confidence: 66%

“…Using inverse hexagonal mesophase (H II ), the authors have shown that small and hydrophilic peptides may be solubilized in the mesophase H II. In vitro studies demonstrated that hexagonal mesophase has the potential to release transdermal desmopressin and increase transdermal permeation of cyclosporine-A [ 100 , 101 , 115 ].…”

Section: Release Absorption and Permeation Mechanismmentioning

confidence: 99%

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Spotlight on Biomimetic Systems Based on Lyotropic Liquid Crystal

et al. 2017

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The behavior of lyotropic biomimetic systems in drug delivery was reviewed. These behaviors are influenced by drug properties, the initial water content, type of lyotropic liquid crystals (LLC), swell ability, drug loading rate, the presence of ions with higher or less kosmotropic or chaotropic force, and the electrostatic interaction between the drug and the lipid bilayers. The in vivo interaction between LCC—drugs, and the impact on the bioavailability of drugs, was reviewed. The LLC with a different architecture can be formed by the self-assembly of lipids in aqueous medium, and can be tuned by the structures and physical properties of the emulsion. These LLC lamellar phase, cubic phase, and hexagonal phase, possess fascinating viscoelastic properties, which make them useful as a dispersion technology, and a highly ordered, thermodynamically stable internal nanostructure, thereby offering the potential as a sustained drug release matrix for drug delivery. In addition, the biodegradable and biocompatible nature of lipids demonstrates a minimum toxicity and thus, they are used for various routes of administration. This review is not intended to provide a comprehensive overview, but focuses on the advantages over non modified conventional materials and LLC biomimetic properties.

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Section: Release Absorption and Permeation Mechanismsupporting

confidence: 66%

Section: Release Absorption and Permeation Mechanismmentioning

confidence: 99%

Spotlight on Biomimetic Systems Based on Lyotropic Liquid Crystal

et al. 2017

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“…1,2 Surfactant-based LCs contain amphiphilic surfactants that dissolve in water 3 and selfassemble into various ordered mesophases. 4 These mesophases are lamellar, hexagonal, or cubic 5 in shape and have attracted attention in the pharmaceutical industry as they have distinctive structures and physicochemical properties, 4 such as viscosity, bioadhesion proprieties, the ability to control the release of drugs, and loading of hydrophilic or lipophilic drugs. [6][7][8][9][10] LCs have been utilized as semisolid vehicles for topical administration of drugs.…”

Section: Introductionmentioning

confidence: 99%

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

Fonseca-Santos

Santos

Rodero

et al. 2016

IJN

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From previous studies, it has been found that curcumin exhibits an anti-inflammatory activity and is being used for the treatment of skin disorders; however, it is hydrophobic and has weak penetrating ability, resulting in poor drug transport through the stratum corneum. The aim of this study was to develop liquid crystalline systems for topical administration of curcumin for the treatment of inflammation. These liquid crystalline systems were developed from oleic acid, polyoxypropylene (5) polyoxyethylene (20) cetyl alcohol, and water as the surfactant, oil phase, and aqueous phase, respectively. These systems were characterized, and polarized light microscopy showed anisotropy with lamellar mesophases (Formulation 1) and hexagonal mesophases (Formulations 2 and 3), which were confirmed by the peak ratio measured using small-angle X-ray scattering. In addition, rheological tests revealed that the formulations exhibited gel-like behavior (G′>G″), as evidenced by the increased G′ values that indicate structured systems. Texture profile analysis showed that hexagonal mesophases have high values of hardness, adhesiveness, and compressibility, which indicate structured systems. In vitro studies on bioadhesion revealed that the hexagonal mesophases increased the bioadhesiveness of the systems to the skin of the pig ear. An in vivo inflammation experiment showed that the curcumin-loaded hexagonal mesophase exhibited an anti-inflammatory activity as compared to the positive control (dexamethasone). The results suggest that this system has a potential to be used as a bioadhesive vehicle for the topical administration of curcumin. Therefore, it is possible to conclude that these systems can be used for the optimization of drug delivery systems to the skin.

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“…Such structures can be found for example in some phases of lyotropic liquid crystals (LLC). Depending on the surfactant concentration, these form different geometries [39] : from spherical in a simple micellar phase to planes in lamellar phase. Such phases can be used to template polymer materials as done using the hexagonal phase in Ref.…”

Section: Anisotropic Diffusionmentioning

confidence: 99%

Physical characterization using diffusion NMR spectroscopy

Zubkov

Dennis

Stait‐Gardner

et al. 2016

Magnetic Reson in Chemistry

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NMR diffusion measurements (or dNMR) provide a powerful tool for analysis of solution organization and microgeometry of the environment by probing random molecular motion. Being a very versatile method, dNMR can be applied to a large variety of samples and systems. Here, a brief introduction into dNMR and a summary of recent advances in the field are presented. The research topics include restricted diffusion, anisotropic diffusion, polymer dynamics, solution structuring and dNMR method development. The dNMR studied systems include plants, cells (cell models), liquid crystals, polymer solutions, ionic liquids, supercooled solutions, untreated water, amino acid solutions and more. It is demonstrated how a variety of dNMR methods can be applied to a system to extract the data on particular structures present among, formed by or surrounding the diffusing particles. It is also demonstrated how dNMR methods can be developed to allow probing larger geometries, low sample concentrations and faster processes. Copyright © 2016 John Wiley & Sons, Ltd.

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Lyotropic liquid crystal systems in drug delivery: a review

Cited by 105 publications

References 74 publications

Spotlight on Biomimetic Systems Based on Lyotropic Liquid Crystal

Spotlight on Biomimetic Systems Based on Lyotropic Liquid Crystal

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

Physical characterization using diffusion NMR spectroscopy

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