Lysine Therapy for Herpes Simplex

Kagan, Christopher

doi:10.1016/s0140-6736(74)92374-5

Cited by 24 publications

(24 citation statements)

References 2 publications

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“…Addi tional in vitro studies of virus yield suggest ed that L-lysine inhibited HSV replication by competitively preventing viral pro grammed enzymatic utilization of Larginine to form viral proteins [14]. Restric tion of dietary L-arginine in subjects prone to recurrent HSV lesions and supplementa tion of the diet with L-lysine may reduce herpes recurrence [3]. Clinical trials in 45 subjects with persistent recurring herpes in fections [4] showed encouraging evidence to support the use of L-lysine supplementation to inhibit HSV attacks.…”

Section: Discussionmentioning

confidence: 99%

“…In published medical reports, Kagan [3], Griffith et al [4], Milman et al [5], Simon et al [6] and Walsh et al [7] have indicated that L-lysine is effective in suppressing recurrent attacks, and speeding the healing of herpes. McCune et al [8], in a blind crossover study, also observed a reduction in the number of herpes attacks in subjects receiving L-lysine.…”

Section: Introductionmentioning

confidence: 99%

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Success of <i>L</i>-Lysine Therapy in Frequently Recurrent Herpes simplex Infection

Griffith

Walsh²,

Myrmel³

et al. 1987

Dermatology

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A double-blind, placebo-controlled, multicenter trial of oral L-lysine monohydrochloride for the prevention and treatment of recurrent herpes simplex (HSV) infection was conducted. The treatment group was given L-Lysine monohydrochloride tablets (1,000 mg L-lysine per dose) 3 times a day for 6 months. A total of 27 (6 male and 21 female) subjects on L-lysine and 25 (6 male and 19 female) subjects on placebo completed the trial. The L-lysine treatment group had an average of 2.4 (p < 0.05) less HSV infections, symptoms were significantly (p < 0.05) diminished in severity and healing time was significantly reduced (p < 0.05). L-Lysine appears to be an effective agent for reduction of occurrence, severity and healing time for recurrent HSV infection.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Success of <i>L</i>-Lysine Therapy in Frequently Recurrent Herpes simplex Infection

Griffith

Walsh²,

Myrmel³

et al. 1987

Dermatology

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“…infections has been under clinical study by several groups since Kagan's small preliminary investigation in 1974 [64], based on a earlier cell-culture study by Tankersley in which he found that the arginine requirement of h.s, virus is high and that L-lysine has an inhibitory effect on h.s. replication [65].…”

Section: Pharmacology Recurrent Herpes Simplexmentioning

confidence: 99%

The metabolic roles, pharmacology, and toxicology of lysine.

Flodin

1997

Journal of the American College of Nutrition

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L-lysine monohydrochloride (LMH) is widely available to the public as a nonprescription oral supplement. Most of the pharmaceutical-grade product is used as a suppressant of recurrent herpes simplex infections. Recent publications indicate the possibility of other therapeutic uses, e.g., in cardiovascular disease and osteoporosis. These and other potential applications are surveyed and evaluated in this review with suggestions for further study. Data on toxicity are reviewed and recommendations made regarding safety of chronic dosage levels.

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“…In an in vitro study, Tankersley [28] found that arginine encouraged whereas lysine antagonized herpesvirus replication and cytopathogenicity. K agan [8] observed clini cally the efficacy of lysine, suggested by Tankersley's in vitro work.…”

Section: Introductionmentioning

confidence: 91%

A Multicentered Study of Lysine Therapy in Herpes simplex Infection

Griffith

Norins

Kagan³

1978

Dermatology

101

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Lysine appears to suppress the clinical manifestations of herpesvirus infection. 45 patients with frequently recurring herpes infection were given 312–1,200 mg of lysine daily in single or multiple doses. The clinical results demonstrated a beneficial effect from supplementary lysine in accelerating recovery from herpes simplex infection and suppressing recurrence. Tissue culture studies have demonstrated an enhancing effect on viral replication when the amino acid ratio of arginine to lysine favors arginine. The opposite, preponderance of lysine to arginine, suppresses viral replication and inhibits cyto-pathogenicity of herpes simplex virus. The codons characterizing herpes simplex DNA apparently specify production of viral capsids at the expense of host cell histones.

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Lysine Therapy for Herpes Simplex

Cited by 24 publications

References 2 publications

Success of <i>L</i>-Lysine Therapy in Frequently Recurrent Herpes simplex Infection

Success of <i>L</i>-Lysine Therapy in Frequently Recurrent Herpes simplex Infection

The metabolic roles, pharmacology, and toxicology of lysine.

A Multicentered Study of Lysine Therapy in Herpes simplex Infection

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