Lysozyme-based nanozyme encapsulated in double-network hydrogel for monitoring and repair of MRSA infected wounds

Le, Guannan; Li, Yuqing; Cai, Ling; Zhang, Li; Pei, Wei; Zhu, Xinyi; Xu, Shangcheng; Zhang, Jiarong; Chen, Jin

doi:10.1016/j.cej.2023.146421

Cited by 16 publications

(2 citation statements)

References 78 publications

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“…these include combining lysozyme with other antimicrobial agents or structurally modifying it through covalent linkage with polysaccharides, fatty acids, and other compounds, as well as using outer membrane permeabilizers (such as EDTA or polycations) to increase its effectiveness against gram‐negative bacteria (Masschalck & Michiels, 2003; Morsy et al., 2018). Additionally, encapsulating lysozyme in nanocarriers or incorporating it into delivery systems can enhance its stability and prolong its antibacterial action, potentially overcoming the limitations posed by gram‐negative bacterial resistance (Le et al., 2023). By employing these innovative technologies, the application of lysozyme in food packaging materials can be expanded, enhancing its overall antibacterial efficacy.…”

Section: Types Of Antimicrobial Substancesmentioning

confidence: 99%

Paper‐based material with hydrophobic and antimicrobial properties: Advanced packaging materials for food applications

Jieying,

Tingting,

Caie

et al. 2024

Comp Rev Food Sci Food Safe

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The environmental challenges posed by plastic pollution have prompted the exploration of eco‐friendly alternatives to disposable plastic packaging and utensils. Paper‐based materials, derived from renewable resources such as wood pulp, non‐wood pulp (bamboo pulp, straw pulp, reed pulp, etc.), and recycled paper fibers, are distinguished by their recyclability and biodegradability, making them promising substitutes in the field of plastic food packaging. Despite their merits, challenges like porosity, hydrophilicity, limited barrier properties, and a lack of functionality have restricted their packaging potential. To address these constraints, researchers have introduced antimicrobial agents, hydrophobic substances, and other functional components to improve both physical and functional properties. This enhancement has resulted in notable improvements in food preservation outcomes in real‐world scenarios. This paper offers a comprehensive review of recent progress in hydrophobic antimicrobial paper‐based materials. In addition to outlining the characteristics and functions of commonly used antimicrobial substances in food packaging, it consolidates the current research landscape and preparation techniques for hydrophobic paper. Furthermore, the paper explores the practical applications of hydrophobic antimicrobial paper‐based materials in agricultural produce, meat, and seafood, as well as ready‐to‐eat food packaging. Finally, challenges in production, application, and recycling processes are outlined to ensure safety and efficacy, and prospects for the future development of antimicrobial hydrophobic paper‐based materials are discussed. Overall, the emergence of hydrophobic antimicrobial paper‐based materials stands out as a robust alternative to plastic food packaging, offering a compelling solution with superior food preservation capabilities. In the future, paper‐based materials with antimicrobial and hydrophobic functionalities are expected to further enhance food safety as promising packaging materials.

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Section: Types Of Antimicrobial Substancesmentioning

confidence: 99%

Paper‐based material with hydrophobic and antimicrobial properties: Advanced packaging materials for food applications

Jieying,

Tingting,

Caie

et al. 2024

Comp Rev Food Sci Food Safe

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“…3 Therefore, it is necessary to explore novel, broad-spectrum, and highly effective antibiotics-independent strategies against pathogenic bacteria. 4 Rapid advances in nanotechnology have shown promise in treating bacterial infections due to nanomaterials' high surface-to-volume ratio, small size, and unusual physical and chemical properties.…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive curcumin/silver/montmorillonite-F127 hydrogels with synergistic photodynamic/photothermal/silver ions antibacterial activity

Liu,

Chen,

Yang

et al. 2024

J. Mater. Chem. B

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Gallium Nanostructure‐Based Microneedle Patch for Multidrug‐Resistant Bacterial Wound Healing: Enhanced Metal Release and NIR Photothermal Effect

Wang,

Zhang,

Feng

et al. 2024

Adv Funct Materials

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Bacterial infections, especially caused by multidrug‐resistant bacteria, pose a big challenge to the healthcare system. As a group of historic agents, metals with broad‐spectrum antibacterial activity are regarded as promising alternatives to tackle antibiotic resistance. Among them, gallium ions have presented encouraging antibacterial effects in research and preclinic studies. However, utilization of gallium ions has difficulty in achieving high targeting and long‐term effectiveness. With the renaissance of liquid metal, here, a novel and facile antibacterial gallium nanostructure is proposed in which polydopamine‐modified gallium nanocore serves as an ion reservoir for enhanced metal ion release and the surface also permits secondary reaction, allowing for in situ formation of Ag nanoparticles to improve the antibacterial property, ROS generation, and photothermal performance. Notably, ≈100% bacterial killing efficacy can be achieved when combined with NIR laser irradiation. The in vivo treatment results of methicillin‐resistant Staphylococcus aureus (MRSA)‐infected mice demonstrate that the microneedle patch loaded with nanoparticles exhibits outstanding bacterial elimination and inflammation alleviation, and promotes angiogenesis and collagen deposition, further accelerating wound healing. This gallium‐based nanostructure offers an effective nanoplatform for antibacterial treatments and combinatory strategies, which holds significant promise for refractory multidrug‐resistant bacteria and related infections.

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Lysozyme-based nanozyme encapsulated in double-network hydrogel for monitoring and repair of MRSA infected wounds

Cited by 16 publications

References 78 publications

Paper‐based material with hydrophobic and antimicrobial properties: Advanced packaging materials for food applications

Paper‐based material with hydrophobic and antimicrobial properties: Advanced packaging materials for food applications

Thermosensitive curcumin/silver/montmorillonite-F127 hydrogels with synergistic photodynamic/photothermal/silver ions antibacterial activity

Gallium Nanostructure‐Based Microneedle Patch for Multidrug‐Resistant Bacterial Wound Healing: Enhanced Metal Release and NIR Photothermal Effect

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