Lysozyme depolymerization of photo-activated chitosan adhesive films

Mawad, Damia; Warren, Charles R.; Barton, Matthew; Mahns, David A.; Morley, John W.; Pham, Binh T.T.; Phạm, Ngọc Hiếu; Kueh, Sindy; Lauto, Antonio

doi:10.1016/j.carbpol.2014.12.008

Cited by 32 publications

(21 citation statements)

References 31 publications

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“…First, chitosan solution was drop-casted on a glass slide to form a well-defined film that was left to dry for 2 weeks. This drying process is simple and scalable: No chemical modification is required for the fabrication of totally insoluble chitosan films ( 21 , 22 ). The second step was drop-casting the mixture of aniline, phytic acid, and ammonium persulfate (APS) on the surface ( 23 ).…”

Section: Resultsmentioning

confidence: 99%

A conducting polymer with enhanced electronic stability applied in cardiac models

et al. 2016

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Section: Resultsmentioning

confidence: 99%

A conducting polymer with enhanced electronic stability applied in cardiac models

et al. 2016

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“…The lysozyme loaded adhesive degraded 20% after 4 weeks implantation into biocompatible monomers and oligomers of glucosamine and N-acetyl-glucosamine. 39 In summary, this study describes a monolayer nanostructured film, which is biocompatible and bonds strongly to tissue upon laser activation. By probing the nanoscale interactions and forces with an atomic force microscope, the study has given insight into the molecular mechanisms of the chitosan adhesive as it is placed under stress.…”

Section: Gecko-inspired Bioadhesive Sj Frost Et Almentioning

confidence: 94%

Gecko-inspired chitosan adhesive for tissue repair

et al. 2016

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The advent of nanotechnology has opened the possibility of fabricating nanoscopic pillars on the surface of polymeric films mimicking the Gecko's foot, in an attempt to increase their adhesive capabilities enhanced by van der Waals forces. However, these forces are considerably weakened in a wet physiological environment. To circumvent this loss in force, current biocompatible adhesives with nanopillars require complex multiple-step fabrication, including an extra layer of adhesive coating to stabilize tissue bonding under physiological conditions. In this report, we describe a simple one-step fabrication process of a single-layer chitosan film that has pillars with base diameter in the range of 100-600 nm and a height of~70 nm. The nanostructured adhesive is laser-bonded to tissue and does not require pillar coating to enhance bonding in water. In comparison with a 'flat' adhesive (without pillars), the nanostructured adhesive bonded significantly stronger to tissue under either stress or pressure. Atomic force spectroscopy also confirmed the superior bonding capability of the nanostructured adhesive. This study demonstrates a one-step fabrication technique to produce a monolayer gecko-inspired adhesive that is biocompatible and bonds effectively to tissue.

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“…CS hydrolyzing enzymes [226]. Non-specific chitosanolytic enzymes belong to heterogeneous enzyme families such as cellulase [227], amylase [228], pectinase [229], papain [230], lysozyme [231,232], or lipases [233] ( Table 4). Although chitinases and chitosanases are very effective, the utilization of non-specific enzymes is more suitable for the low-cost production of COS [234].…”

Section: Biodegradability Of Chitosan Derivatives and Life Cycle Assementioning

confidence: 99%

Modification of Chitosan for the Generation of Functional Derivatives

et al. 2019

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Today, chitosan (CS) is probably considered as a biofunctional polysaccharide with the most notable growth and potential for applications in various fields. The progress in chitin chemistry and the need to replace additives and non-natural polymers with functional natural-based polymers have opened many new opportunities for CS and its derivatives. Thanks to the specific reactive groups of CS and easy chemical modifications, a wide range of physico-chemical and biological properties can be obtained from this ubiquitous polysaccharide that is composed of β-(1,4)-2-acetamido-2-deoxy-d-glucose repeating units. This review is presented to share insights into multiple native/modified CSs and chitooligosaccharides (COS) associated with their functional properties. An overview will be given on bioadhesive applications, antimicrobial activities, adsorption, and chelation in the wine industry, as well as developments in medical fields or biodegradability.

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Lysozyme depolymerization of photo-activated chitosan adhesive films

Cited by 32 publications

References 31 publications

A conducting polymer with enhanced electronic stability applied in cardiac models

A conducting polymer with enhanced electronic stability applied in cardiac models

Gecko-inspired chitosan adhesive for tissue repair

Modification of Chitosan for the Generation of Functional Derivatives

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