M2 macrophages promote pulmonary endothelial cells regeneration in sepsis-induced acute lung injury

Shen, Ya-Xing; Song, Jieqiong; Wang, Yingqin; Chen, Zhenglong; Zhang, Lin; Yu, Jie; Zhu, Dexiang; Zhong, Ming

doi:10.21037/atm.2019.02.47

Cited by 38 publications

(37 citation statements)

References 28 publications

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“…Most notably, macrophages of the M2 phenotype have a greater phagocytotic function resulting in increased clearance of apoptotic cells and an acceleration of resolution ( 39 ). Indeed, M2 macrophages protect against sepsis-induced lung injury ( 51 ) and sepsis-induced acute kidney injury ( 52 ). Transplantation of M2 macrophages has been suggested as a potential therapeutic approach for sepsis-induced lung injury ( 51 ).…”

Section: Discussionmentioning

confidence: 99%

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X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure

et al. 2020

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We previously reported the Bruton's tyrosine kinase (BTK) inhibitors ibrutinib and acalabrutinib improve outcomes in a mouse model of polymicrobial sepsis. Now we show that genetic deficiency of the BTK gene alone in Xid mice confers protection against cardiac, renal, and liver injury in polymicrobial sepsis and reduces hyperimmune stimulation (“cytokine storm”) induced by an overwhelming bacterial infection. Protection is due in part to enhanced bacterial phagocytosis in vivo , changes in lipid metabolism and decreased activation of NF-κB and the NLRP3 inflammasome. The inactivation of BTK leads to reduced innate immune cell recruitment and a phenotypic switch from M1 to M2 macrophages, aiding in the resolution of sepsis. We have also found that BTK expression in humans is increased in the blood of septic non-survivors, while lower expression is associated with survival from sepsis. Importantly no further reduction in organ damage, cytokine production, or changes in plasma metabolites is seen in Xid mice treated with the BTK inhibitor ibrutinib, demonstrating that the protective effects of BTK inhibitors in polymicrobial sepsis are mediated solely by inhibition of BTK and not by off-target effects of this class of drugs.

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Section: Discussionmentioning

confidence: 99%

“…Indeed, M2 macrophages protect against sepsis-induced lung injury ( 51 ) and sepsis-induced acute kidney injury ( 52 ). Transplantation of M2 macrophages has been suggested as a potential therapeutic approach for sepsis-induced lung injury ( 51 ).…”

Section: Discussionmentioning

confidence: 99%

X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure

et al. 2020

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“…Imbalanced inflammation, uncontrolled accumulation of leukocytes and platelets, and the change in tissues barriers are the main pathophysiological characteristics of acute lung injury [ 19 ]. MaR1 is known to participate in various pharmacological functions, such as cells immunoreaction [ 20 ], tissue regeneration, and pain [ 21 ]. However, whether MaR1 has a protective effect in THS-induced lung injury and the underlying mechanisms in disease progress are still not well understood.…”

Section: Discussionmentioning

confidence: 99%

Role and Mechanism of Maresin-1 in Acute Lung Injury Induced by Trauma-Hemorrhagic Shock

et al. 2020

Med Sci Monit

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“…CDH11 have a positive relationship not only with the infiltration level of macrophages in the TME of GC but also with cytokines secreted by macrophages and gene markers such as CCL2, CXCL12, and TGFB1 of TAMs and IL10, IL1R1, CD163, and MRC1 of M2. As inducers, CCL2, TGFB1, CXCL12, and MMP2 not only recruit more macrophages into the TME but also facilitate their polarization and the generation of more M2 macrophages [ 12 , 54 – 58 ]. High expression of M2-related markers often reflects the increased proportion of M2 macrophages in the TME [ 20 , 37 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic and Predictive Value of Cadherin 11 for Patients with Gastric Cancer and Its Correlation with Tumor Microenvironment: Results from Microarray Analysis

Feng

Xue

Ren

et al. 2020

BioMed Research International

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Gastric cancer is a disease characterized by inflammation, and epithelial-to-mesenchymal transition (EMT) and tumor-associated macrophages (TAMs) both play a vital role in epithelial-driven malignancy. In the present study, we performed an integrated bioinformatics analysis of transcriptome data from multiple databases of gastric cancer patients and worked on a biomarker for evaluating tumor prognosis. We found that cadherin 11 (CDH11) is highly expressed not only in gastric cancer tissues but also in EMT molecular subtypes and metastatic patients. Also, we obtained evidence that CDH11 has a significant correlation with infiltrating immune cells in the tumor microenvironment (TME). Our findings reflected that CDH11 likely plays an important role in tumor immune escape and could provide a prognostic biomarker and potential therapeutic target for patients with gastric cancer.

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M2 macrophages promote pulmonary endothelial cells regeneration in sepsis-induced acute lung injury

Cited by 38 publications

References 28 publications

X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure

X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure

Role and Mechanism of Maresin-1 in Acute Lung Injury Induced by Trauma-Hemorrhagic Shock

Prognostic and Predictive Value of Cadherin 11 for Patients with Gastric Cancer and Its Correlation with Tumor Microenvironment: Results from Microarray Analysis

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