2022
DOI: 10.3389/fgene.2022.853258
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m5Cpred-XS: A New Method for Predicting RNA m5C Sites Based on XGBoost and SHAP

Abstract: As one of the most important post-transcriptional modifications of RNA, 5-cytosine-methylation (m5C) is reported to closely relate to many chemical reactions and biological functions in cells. Recently, several computational methods have been proposed for identifying m5C sites. However, the accuracy and efficiency are still not satisfactory. In this study, we proposed a new method, m5Cpred-XS, for predicting m5C sites of H. sapiens, M. musculus, and A. thaliana. First, the powerful SHAP method was used to sele… Show more

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Cited by 6 publications
(1 citation statement)
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“…Therefore, there is an urgent need to develop computational methods to automatically detect and identify these 5mC sites, providing biologists with more efficient and convenient tools. In recent years, an increasing number of models based on machine learning constructs have been used to identify 5mC sites, such as Stacking Ensemble [ 11 ], XGBoost [ 12 ] and SVM [ 13 , 14 ]. These models have greatly facilitated the study of the 5mC site, allowing researchers to probe this methylation type in greater depth.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, there is an urgent need to develop computational methods to automatically detect and identify these 5mC sites, providing biologists with more efficient and convenient tools. In recent years, an increasing number of models based on machine learning constructs have been used to identify 5mC sites, such as Stacking Ensemble [ 11 ], XGBoost [ 12 ] and SVM [ 13 , 14 ]. These models have greatly facilitated the study of the 5mC site, allowing researchers to probe this methylation type in greater depth.…”
Section: Introductionmentioning
confidence: 99%