Maca: Botanical Medicine from the Andes

Rosales-Hartshorn, Maria

doi:10.17140/aftnsoj-1-e001

Cited by 4 publications

(3 citation statements)

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“…The edible part of maca, the hypocotyl, has been widely used to treat osteoporosis [ 65 ]. Ethanol extract of maca has anti-osteoporotic activity and indicated maca alkaloids, steroids, glucosinolates, isothiocyanates, and macamides are probably responsible for its biological functions [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…Several in vitro/in vivo animal experimental studies have shown that secondary metabolites extracted from maca have bioactivities that help treat osteoporosis and enhance prostate function and sexual function [ 19 – 21 ]. However, most in vitro and in vivo experiments have not specified the molecular target of these secondary metabolites and the mechanisms of the functions of the compounds obtained from maca are unclear.…”

Section: Introductionmentioning

confidence: 99%

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In silico profiling for secondary metabolites from Lepidium meyenii (maca) by the pharmacophore and ligand-shape-based joint approach

Tan

Yan

2016

Chin Med

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BackgroundLepidium meyenii Walpers (maca) is an herb known as a traditional nutritional supplement and widely used in Peru, North America, and Europe to enhance human fertility and treat osteoporosis. The secondary metabolites of maca, namely, maca alkaloids, macaenes, and macamides, are bioactive compounds, but their targets are undefined.MethodsThe pharmacophore-based PharmaDB targets database screening joint the ligand shape similarity-based WEGA validation approach is proposed to predict the targets of these unique constituents and was performed using Discovery Studio 4.5 and PharmaDB. A compounds–targets–diseases network was established using Cytoscape 3.2. These suitable targets and their genes were calculated and analyzed using ingenuity pathway analysis and GeneMANIA.ResultsCertain targets were identified in osteoporosis (8 targets), prostate cancer (9 targets), and kidney diseases (11 targets). This was the first study to identify the targets of these bioactive compounds in maca for cardiovascular diseases (29 targets). The compound with the most targets (46) was an amide alkaloid (MA-24).ConclusionIn silico target fishing identified maca’s traditional effects on treatment and prevention of osteoporosis, prostate cancer, and kidney diseases, and its potential function of treating cardiovascular diseases, as the most important of this herb’s possible activities.Electronic supplementary materialThe online version of this article (doi:10.1186/s13020-016-0112-y) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In silico profiling for secondary metabolites from Lepidium meyenii (maca) by the pharmacophore and ligand-shape-based joint approach

Tan

Yan

2016

Chin Med

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“…Recently, El-Sheikh et al [55] reported that maca-treated rabbit does have a numerically higher concentration of E2 hormone and a lower concentration of P4 hormone than those in the control group. This and the enhancement of serum LH levels may be the mechanisms that improve fertility [87]. The positive effects of maca may be due to saponins, which play an important role in sex hormone secretion and the treatment of sexual dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Black Maca (Lepidium meyenii Walp.) Hydroalcoholic Extract as an Ameliorating Agent against Heat Stress Conditions of V-Line Rabbit Does

et al. 2022

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Rabbits are sensitive to heat stress (HS) in hot regions due to difficulty in eliminating excess body heat. We evaluated the ameliorating role of black maca hydroalcoholic extract (BMHE) against HS conditions on the productive and reproductive performance of V-line rabbit does. Rabbits were divided into four equal groups (T1–T4), each containing three replicates. T1 received commercial basal diet (BD) only, whereas T2–T4 received BD and 200, 400, and 600 mg BMHE kg−1 body weight (BW) of doe day−1, respectively, administered orally for 1 week before the mating process each month from May to August. HS significantly decreased the BW of rabbits after the weaning period, as well as litter size, and litter weights measured 7, 14, 21, and 28 days after the postnatal period. HS conditions also significantly decreased BW at slaughter as well as all carcass quality parameters. HS led to significantly impaired physiological responses, oxidative status, and reproductive efficiency in exposed rabbits. Orally administered 400 mg BMHE kg−1 BW of doe alleviated all these drastic effects in HS rabbits among all treatments. Thus, oral treatment of 400 mg BMHE kg−1 BW (T3) is a promising ameliorating agent against HS conditions in V-line rabbit does, especially in tropical or subtropical regions.

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Acceptance of herbal medicines in andrology

George

Liske

2021

Herbal Medicine in Andrology

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Maca: Botanical Medicine from the Andes

Abstract: CitationRosales-Hartshorn M. Maca: Botanical medicine from the andes. Adv Food Technol Nutr Sci Open J. 2015; 1(2): e1-e6.

Cited by 4 publications

References 15 publications

In silico profiling for secondary metabolites from Lepidium meyenii (maca) by the pharmacophore and ligand-shape-based joint approach

In silico profiling for secondary metabolites from Lepidium meyenii (maca) by the pharmacophore and ligand-shape-based joint approach

Black Maca (Lepidium meyenii Walp.) Hydroalcoholic Extract as an Ameliorating Agent against Heat Stress Conditions of V-Line Rabbit Does

Acceptance of herbal medicines in andrology

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