2022
DOI: 10.1101/2022.02.15.22270625
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Machine learning analysis reveals biomarkers for the detection of neurodegenerative diseases

Abstract: It is critical to identify biomarkers for neurodegenerative diseases (NDDs) to advance disease diagnosis and accelerate drug discovery for effective treatment of patients. In this work, we retrieved genotyping and clinical data from 1223 UK Biobank participants to identify genetic and clinical biomarkers for NDDs, including Alzheimer’s disease (AD), Parkinson’s disease (PD), motor neuron disease (MND), and myasthenia gravis (MG). Using a machine learning modelling approach and Monte Carlo randomisation, we ide… Show more

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