Machine learning and matrix-assisted laser desorption/ionization time-of-flight mass spectra for antimicrobial resistance prediction: A systematic review of recent advancements and future development

López-Cortés, Xaviera A.; Manríquez-Troncoso, José M.; Kandalaft-Letelier, John; Cuadros-Orellana, Sara

doi:10.1016/j.chroma.2024.465262

Journal of Chromatography A

2024

DOI: 10.1016/j.chroma.2024.465262

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Machine learning and matrix-assisted laser desorption/ionization time-of-flight mass spectra for antimicrobial resistance prediction: A systematic review of recent advancements and future development

Xaviera A. López-Cortés,

José M. Manríquez-Troncoso,

John Kandalaft-Letelier

et al.

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2024

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Predicting Bacterial Antibiotic Resistance using MALDI-TOF Mass Spectrometry Databases with ELM Applications.

Tirado,

Lopez Cortez,

Macaya Mejías

et al. 2024

JCS&T

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Early detection of antibiotic resistance is a crucial task, especially for vulnerable patients under prolonged treatments with a single antibiotic. To solve this, machine learning approaches have been reported in the state of art. Researchers have used MALDI-TOF MS in order to predict antibiotic resistance and/or susceptibility in bacterial samples. Weis, et al. implemented LR, LightGBM and ANN to study the antibiotic resistance on bacterial strains of Escherichia Coli, Staphylococcus Aureus, and Klebsiella Pneumoniae. Despite promising results, the models have not achieved perfect accuracy, specifically when the classes are unbalanced. On the other hand, Extreme Learning Machine (ELM) is a training algorithm for forward propagation of single hidden layer neural networks, which converges much faster than traditional methods and offers promising performance along with less programmer intervention. In this way, this study introduced improved ELMs, including two weighted ELMs proposed by Zong, and the SMOTE technique in order to create new synthetic samples of the minority class. After heuristic optimization of ELM hiper-parameters, results demonstrated 85% in accuracy and 85% in geometric mean for the classification problem in the case of weighted ELM 1 subject to the SMOTE technique of oversampling.

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Predicting Bacterial Antibiotic Resistance using MALDI-TOF Mass Spectrometry Databases with ELM Applications.

Tirado,

Lopez Cortez,

Macaya Mejías

et al. 2024

JCS&T

View full text Add to dashboard Cite

show abstract

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Machine learning and matrix-assisted laser desorption/ionization time-of-flight mass spectra for antimicrobial resistance prediction: A systematic review of recent advancements and future development

Cited by 1 publication

References 76 publications

Predicting Bacterial Antibiotic Resistance using MALDI-TOF Mass Spectrometry Databases with ELM Applications.

Predicting Bacterial Antibiotic Resistance using MALDI-TOF Mass Spectrometry Databases with ELM Applications.

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