Macro- and Microscale Rheological Properties of Poly(vinyl alcohol) Aqueous Solutions

Krise, Keith M.; Hwang, Angela; Sović, David; Milosavljevic, Bratoljub H.

doi:10.1021/jp109451d

Cited by 13 publications

(22 citation statements)

References 39 publications

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“…This behavior agrees with previous reports highlighting the fact that macroviscosity does not always correlates with the microviscosity (i.e., resistance of the medium to the diffusion of small molecules) [53]. Indeed, it has been shown that the cross-linking of a polymer may lead to a rapid rise in macroviscosty while the movement of small molecules through the network is not altered since they move through the so called "interconnected water pools" among the chains [54].…”

Section: Formulationsupporting

confidence: 92%

Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir

et al. 2020

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Acyclovir (ACV) is one of the most used antiviral drugs for the treatment of herpes simplex virus infections and other relevant mucosal infections caused by viruses. Nevertheless, the low water solubility of ACV limits both its bioavailability and antiviral performance. The combination of block copolymer micelles and cyclodextrins (CDs) may result in polypseudorotaxanes with tunable drug solubilizing and gelling properties. However, the simultaneous addition of various CDs has barely been investigated yet. The aim of this work was to design and characterize ternary combinations of Pluronic® F127 (PF127), αCD and βCD in terms of polypseudorotaxane formation, rheological behavior, and ACV solubilization ability and controlled release. The formation of polypseudorotaxanes between PF127 and the CDs was confirmed by FT-IR spectroscopy, X-ray diffraction, and NMR spectroscopy. The effects of αCD/βCD concentration range (0–7% w/w) on copolymer (6.5% w/w) gel features were evaluated at 20 and 37 °C by rheological studies, resulting in changes of the copolymer gelling properties. PF127 with αCD/βCD improved the solubilization of ACV, maintaining the biocompatibility (hen’s egg test on the chorio-allantoic membrane). In addition, the gels were able to sustain acyclovir delivery. The formulation prepared with similar proportions of αCD and βCD provided a slower and more constant release. The results obtained suggest that the combination of Pluronic with αCD/βCD mixtures can be a valuable approach to tune the rheological features and drug release profiles from these supramolecular gels.

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Section: Formulationsupporting

confidence: 92%

Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir

et al. 2020

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“…41–44 A study showed that the diffusion of “small” molecules or ions through the solutions of this polymer was not affected by the presence of “large” polymer molecules. 40…”

Section: Introductionmentioning

confidence: 99%

“…16,17,[37][38][39] Polyvinyl alcohol (PVA) is a hydrophilic polymer with hydrated molecules when dissolved in water. 40 It has been widely used for drug delivery systems, wound dressing, and other medical prosthetics because of its biocompatible properties. [41][42][43][44] A study showed that the diffusion of "small" molecules or ions through the solutions of this polymer was not affected by the presence of "large" polymer molecules.…”

Section: Introductionmentioning

confidence: 99%

“…[41][42][43][44] A study showed that the diffusion of "small" molecules or ions through the solutions of this polymer was not affected by the presence of "large" polymer molecules. 40 Liang et al 45 prepared a solution of nanocomposites made of GO nanoribbons with PVA with improved mechanical properties due to the molecular-level dispersion of GO. Another study showed that the same functional groups on the surface of GO and polymer matrix enhance the dispersion of GO in PVA.…”

Section: Introductionmentioning

confidence: 99%

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Rheological and physical properties of a nanocomposite of graphene oxide nanoribbons with polyvinyl alcohol

Javanbakht

David

2020

Journal of Thermoplastic Composite Materials

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In this work, the physicochemical and rheological properties of a nanocomposite of graphene oxide (GO) and thermoplastic polyvinyl alcohol (PVA) are reported. After adding deionized water to PVA, the sample was heated and mixed. The polymer solution was divided in two portions, each of them containing PVA in water. GO nanoribbons were added to one portion of the PVA solution in water to obtain the nanocomposite suspension (1% w/w). The similarity of the Fourier-transform infrared spectra of PVA and its related nanocomposite was assessed (both having similar peaks, an important observation as it indicated the water absorption on the samples). The scanning electron microscopy images showed that PVA lost its spherical shape in composites due to the GO sheets coating. The characteristic peaks O− ( m/ e 16) and OH− ( m/ e 17) were observed in the time-of-flight secondary ion mass spectrometry negative mode spectra of PVA and nanocomposite of GO nanoribbons with PVA. The analysis of the OH−, O−, C2H−, and C2 − peaks of PVA and the nanocomposite of GO nanoribbons revealed that a reduction occurred for GO nanoribbons when coated with PVA. The rheological behaviors of samples in solution were studied and their shear rate versus shear stress were assessed. A non-Newtonian rheological behavior of the nanocomposite of GO nanoribbons with PVA was observed. The dielectric response of the nanocomposite of GO-PVA featured a simultaneous increase of both real and imaginary part of the complex permittivity toward low frequency due to the contribution of charge carriers. These results provide more understanding about the physical, mechanical, and dielectric properties of GO-PVA nanocomposite to make it appropriate in the construction of embedded capacitors. The novelty of our work lies in the rheological and physical properties of this nanocomposite in comparison with those of PVA that have not been previously reported.

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“…This work expands on our previous work with simple aqueous polymer solutions in which we showed that (despite high macroviscosity) the physiochemical properties of water in poly(vinyl alcohol) aqueous solutions (up to 10% (w/w)) were the same as those of pure water. 12 Here using diffusion-controlled reactions and electric conductivity involving small reactants and ions, we investigated the mobility of molecules and ions solubilized within the thick fraction of egg white to characterize its microscale rheological properties. Differential scanning calorimetry (DSC) was used to gain further information about the amount of bound water in the hydrogel as well as water pool and channel sizes within the thick fraction.…”

mentioning

confidence: 99%

Mobility of Molecules and Ions Solubilized in Protein Gels: Diffusion in the Thick Fraction of Hen Egg White

Krise

Milosavljevic

2011

Biomacromolecules

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The thick fraction of hen egg white is a protein hydrogel with an immeasurably high viscosity composed of ∼90% water that can serve as a model system for mammalian mucous membrane. Measurements of the rate constants of diffusion-controlled reactions occurring within the gel (and corresponding activation energies) and electric conductivity revealed that the thick fraction of egg white can be envisioned as a 3D network comprising hydrated protein molecules (held by intermolecular S-S bridges) surrounded by water pools and channels (of nonuniform diameters) that have a microviscosity that is very similar to that of bulk water. This was corroborated by differential scanning calorimetry measurements that revealed that 16% of water is bound to proteins. The melting kinetics of ice crystallites (produced from the freezable water) indicates nonhomogeneous water pool size.

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Macro- and Microscale Rheological Properties of Poly(vinyl alcohol) Aqueous Solutions

Cited by 13 publications

References 39 publications

Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir

Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir

Rheological and physical properties of a nanocomposite of graphene oxide nanoribbons with polyvinyl alcohol

Mobility of Molecules and Ions Solubilized in Protein Gels: Diffusion in the Thick Fraction of Hen Egg White

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